It has long been suspected that removing senescent cells locally is insufficient to treat age-related conditions in which the pro-inflammatory signaling produced by senescent cells contributes to pathology. These signals enter the bloodstream and are carried widely about the body. While the effect of a distant senescent cell on local pathology is more dilute than that of a local senescent cell, there are a lot more distant senescent cells than there are local senescent cells. This issue is likely why Unity Biotechnology’s initial clinical trial of localized removal of senescent cells in osteoarthritic knee joints failed to produce sufficiently lar…
As Suspected, Local Clearance of Senescent Cells isn't as Effective as Global Clearance for Osteoporosis
It has long been suspected that removing senescent cells locally is insufficient to treat age-related conditions in which the pro-inflammatory signaling produced by senescent cells contributes to pathology. These signals enter the bloodstream and are carried widely about the body. While the effect of a distant senescent cell on local pathology is more dilute than that of a local senescent cell, there are a lot more distant senescent cells than there are local senescent cells. This issue is likely why Unity Biotechnology’s initial clinical trial of localized removal of senescent cells in osteoarthritic knee joints failed to produce sufficiently lar…