Beta cells in the pancreas produce insulin and are essential to the regulation of glucose metabolism. Dysfunction in this cell population causes diabetes, whether the origin is autoimmune destruction of beta cells (type 1 diabetes) or senescence of beta cells brought on by obesity (type 2 diabetes). Aging also impairs beta cell function through some of the same mechanisms, such as cellular senescence and constant, unresolved inflammatory signaling. The practice of <…
Calorie Restriction Improves Pancreatic Function in Aging Mammals
Beta cells in the pancreas produce insulin and are essential to the regulation of glucose metabolism. Dysfunction in this cell population causes diabetes, whether the origin is autoimmune destruction of beta cells (type 1 diabetes) or senescence of beta cells brought on by obesity (type 2 diabetes). Aging also impairs beta cell function through some of the same mechanisms, such as cellular senescence and constant, unresolved inflammatory signaling. The practice of <…