The amyloid cascade hypothesis of Alzheimer’s disease suggests that aggregation of misfolded amyloid-β sets the stage for a feedback loop between chronic inflammation of brain tissue and tau aggregation. It is that second step that causes severe pathology and death, and once it is underway in earnest a patient’s amyloid-β burden is of little relevance. This the explanation given for the lack of patient benefits resulting from the <a href="https://www.fightagin…
Can Removing Amyloid Early Benefit Alzheimer's Disease Patients?
The amyloid cascade hypothesis of Alzheimer’s disease suggests that aggregation of misfolded amyloid-β sets the stage for a feedback loop between chronic inflammation of brain tissue and tau aggregation. It is that second step that causes severe pathology and death, and once it is underway in earnest a patient’s amyloid-β burden is of little relevance. This the explanation given for the lack of patient benefits resulting from the <a href="https://www.fightagin…