Reminiscent of recent work on supplementation of the amino acid taurine as a means to modestly slow aging, the authors of today’s open access paper examine the role of the amino acid citrulline in age-related changes occurring in mice. As is true of taurine in mice, blood and tissue levels of citrulline decline to varied degrees with age, while long-term oral supplementation with citrulline both restores youthful levels and improves a number of measures of metabolism. This includes a reduction in age-related chronic inflammation that appears mediated by changes in the behavior of the <a href…
Circulating Citrulline Declines with Age, and Supplementation is Anti-Inflammatory in Mice
Reminiscent of recent work on supplementation of the amino acid taurine as a means to modestly slow aging, the authors of today’s open access paper examine the role of the amino acid citrulline in age-related changes occurring in mice. As is true of taurine in mice, blood and tissue levels of citrulline decline to varied degrees with age, while long-term oral supplementation with citrulline both restores youthful levels and improves a number of measures of metabolism. This includes a reduction in age-related chronic inflammation that appears mediated by changes in the behavior of the <a href…