Source https://www.fightaging.org/archives/2022/05/cyclic-foxm1-upregulation-extends-life-in-aged-mice/
The Lifespan.io team here notes a recent study in which researchers carefully induced greater expression of FOXM1 in aged mice, showing extension of life as a result. FOXM1 overexpression is known to induce greater stem cell activity, but also to push somatic cells towards a more cancer-like phenotype, meaning more growth, more regeneration, more activity. Cancer and regeneration are two sides of the same coin. Regeneration and tissue maintenance are controlled processes, while a cancer is driven by the same mechanisms when they run wild.
Given these connections, it is not too surprising to find that FOXM1 is downregulated in older individuals, perhaps a part …
Source https://www.fightaging.org/archives/2022/05/cyclic-foxm1-upregulation-extends-life-in-aged-mice/
The Lifespan.io team here notes a recent study in which researchers carefully induced greater expression of FOXM1 in aged mice, showing extension of life as a result. FOXM1 overexpression is known to induce greater stem cell activity, but also to push somatic cells towards a more cancer-like phenotype, meaning more growth, more regeneration, more activity. Cancer and regeneration are two sides of the same coin. Regeneration and tissue maintenance are controlled processes, while a cancer is driven by the same mechanisms when they run wild.
Given these connections, it is not too surprising to find that FOXM1 is downregulated in older individuals, perhaps a part …
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