This review paper lumps together thoughts on the prospects for both epigenetic reprogramming and upregulation of autophagy as approaches to the treatment of Alzheimer’s disease, the former a much more recent development in the research community, and the latter a long-running goal that has seen less concrete progress than desired. The long, slow path to any sort of success in the development of Alzheimer’s therapies based on clearance of amyloid-β has led to considerable pressure to try other other avenues, but despi…
Epigenetic Reprogramming as a Treatment for Alzheimer's Disease
This review paper lumps together thoughts on the prospects for both epigenetic reprogramming and upregulation of autophagy as approaches to the treatment of Alzheimer’s disease, the former a much more recent development in the research community, and the latter a long-running goal that has seen less concrete progress than desired. The long, slow path to any sort of success in the development of Alzheimer’s therapies based on clearance of amyloid-β has led to considerable pressure to try other other avenues, but despi…