Source https://www.fightaging.org/archives/2023/01/extracellular-matrix-stiffening-contributes-to-cartilage-aging-and-osteoarthritis/
Age-related changes in the structure of the extracellular matrix that surrounds and supports cells are not as well studied as changes in cell behavior. Nonetheless, there is plenty of evidence for changes in the extracellular matrix to negatively affect tissue function. Cells create and maintain the matrix, but the state of the matrix in turn influences cells, and over time is affected by more than just cell behavior. Metabolic processes can alter and fragment elastin, cross-link collagen molecules, and so forth.
Cross-linking of matrix molecules occurs with age as a byproduct of the normal operation of metabolism, reducing flexibility and increasing stiffness. Targeting this cross-linking is…
Source https://www.fightaging.org/archives/2023/01/extracellular-matrix-stiffening-contributes-to-cartilage-aging-and-osteoarthritis/
Age-related changes in the structure of the extracellular matrix that surrounds and supports cells are not as well studied as changes in cell behavior. Nonetheless, there is plenty of evidence for changes in the extracellular matrix to negatively affect tissue function. Cells create and maintain the matrix, but the state of the matrix in turn influences cells, and over time is affected by more than just cell behavior. Metabolic processes can alter and fragment elastin, cross-link collagen molecules, and so forth.
Cross-linking of matrix molecules occurs with age as a byproduct of the normal operation of metabolism, reducing flexibility and increasing stiffness. Targeting this cross-linking is…
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