Source https://www.fightaging.org/archives/2025/04/extracellular-vesicles-from-the-brain-promote-regeneration-without-scarring-in-skin/
Research can be interesting even if the future development of therapies based on that research seems challenging. Today’s open access paper is chiefly interesting for its outline of the developmental and ongoing relationship between skin and the brain, and the signaling that passes between the two. It is intriguing that this relationship means that one can harvest extracellular vesicles generated by cells in the brain and use them to change skin cell behavior in order to produce scar free regeneration from injury.
However, to make this into a therapy would require either (a) a much greater understanding of the specific signaling mechanisms involved, in order to replace the vesicles with some other way to manipulate those mechanisms, or (b) the ability to maintain human organoid brain tissues at scale for the purpose of harvesting vesicles. …
Source https://www.fightaging.org/archives/2025/04/extracellular-vesicles-from-the-brain-promote-regeneration-without-scarring-in-skin/
Research can be interesting even if the future development of therapies based on that research seems challenging. Today’s open access paper is chiefly interesting for its outline of the developmental and ongoing relationship between skin and the brain, and the signaling that passes between the two. It is intriguing that this relationship means that one can harvest extracellular vesicles generated by cells in the brain and use them to change skin cell behavior in order to produce scar free regeneration from injury.
However, to make this into a therapy would require either (a) a much greater understanding of the specific signaling mechanisms involved, in order to replace the vesicles with some other way to manipulate those mechanisms, or (b) the ability to maintain human organoid brain tissues at scale for the purpose of harvesting vesicles. …
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