Gene Therapy with VEGF-C Restores Lost Lymphatic Drainage of Cerebrospinal Fluid in Aged Mice

Source https://www.fightaging.org/archives/2025/03/gene-therapy-with-vegf-c-restores-lost-lymphatic-drainage-of-cerebrospinal-fluid-in-aged-mice/

Cerebrospinal fluid is produced constantly, circulates through the brain, and drains into the body. This flow carries metabolic waste from the brain, and researchers are coming to view the age-related impairment of cerebrospinal fluid drainage as an important contribution to loss of cognitive function and the development of neurodegenerative conditions in later life. Several pathways for drainage have been identified, each of which is known to lose function with advancing age.

Firstly, cerebrospinal fluid drains through holes in the cribriform plate behind the nose. This pathway ossifies and closes up with age or injury. Studies conducted by Leucadia Therapeutics have added a weight of evidence to the importance of impairment of this fluid dr…

Source https://www.fightaging.org/archives/2025/03/gene-therapy-with-vegf-c-restores-lost-lymphatic-drainage-of-cerebrospinal-fluid-in-aged-mice/

Cerebrospinal fluid is produced constantly, circulates through the brain, and drains into the body. This flow carries metabolic waste from the brain, and researchers are coming to view the age-related impairment of cerebrospinal fluid drainage as an important contribution to loss of cognitive function and the development of neurodegenerative conditions in later life. Several pathways for drainage have been identified, each of which is known to lose function with advancing age.

Firstly, cerebrospinal fluid drains through holes in the cribriform plate behind the nose. This pathway ossifies and closes up with age or injury. Studies conducted by Leucadia Therapeutics have added a weight of evidence to the importance of impairment of this fluid dr…

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