Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis

Source https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/

Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way that can be compensated for by adding more leucine to the diet. Whether this actually works is a matter for debate; the evidence is mixed. The question is never whether the mechanism exists, the question is whether it has a large enough effect size to matter.

Given this impetus for a greater intake of dietary leucine in later life, it is interesting to see the research noted here, in which higher dietary protein intake, and …

Source https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/

Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way that can be compensated for by adding more leucine to the diet. Whether this actually works is a matter for debate; the evidence is mixed. The question is never whether the mechanism exists, the question is whether it has a large enough effect size to matter.

Given this impetus for a greater intake of dietary leucine in later life, it is interesting to see the research noted here, in which higher dietary protein intake, and …

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