Inflammatory Microglia Disrupt the Cholinergic Systems of the Aging Brain

Source https://www.fightaging.org/archives/2023/11/inflammatory-microglia-disrupt-the-cholinergic-systems-of-the-aging-brain/

Cholinergic neurons are important in many functions in the brain. It is becoming apparent that chronic inflammation in brain tissue is an important contributing cause in the decline of cholinergic systems of brain function. Microglia, innate immune cells of the brain, are one of the cell populations responsible for sustaining harmful inflammation. These cells become active and inflammatory in ever increasing numbers in the aging brain, a maladaptive reaction to growing levels of metabolic waste and pro-inflammatory signaling outside cells, alongside age-related dysfunction inside cells.

This study assessed the effect of normal aging and neuroinflammation on the medial septal <a href="https://en.wikipedia.org/wi…

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