Decreased S6K expression is one of the downstream consequences of treatment with the mTOR inhibitor rapamycin, and is essential for mTOR inhibition to extend life in mice and other laboratory species. It is thought that the slowing of aging resulting from mTOR inhibition largely works via improved operation of the complex cell maintenance processes of autophagy, wherein damaged proteins are flagged, wrapped in membranes, and conveyed to a lysosome for recycling. Researchers here investigate the role of S6K, and note that it appears to reduce the excessive inflammatory signaling characteristic of old age in addition to improving ly…
Investigating the Role of S6K in the Slowed Aging Produced by Rapamycin
Decreased S6K expression is one of the downstream consequences of treatment with the mTOR inhibitor rapamycin, and is essential for mTOR inhibition to extend life in mice and other laboratory species. It is thought that the slowing of aging resulting from mTOR inhibition largely works via improved operation of the complex cell maintenance processes of autophagy, wherein damaged proteins are flagged, wrapped in membranes, and conveyed to a lysosome for recycling. Researchers here investigate the role of S6K, and note that it appears to reduce the excessive inflammatory signaling characteristic of old age in addition to improving ly…