The early stages of Alzheimer’s disease are characterized by rising levels of amyloid-β in the brain and the formation of misfolded amyloid aggregates. It is presently thought that this is a necessary precursor for the more harmful later stages of the condition, in which chronic inflammation and tau aggregation cause widespread cell death in the brain. It has been noted that amyloid-β exists outside the brain, and there is evidence for levels of amyloid-β in the vasculature to be in dynamic equilibrium with amyloid-β in the brain. <a href="https://www.fightaging.org/archives/2018/10/a-phase-iii-trial-based-on-the-peripheral-a…
Is the Gut a Significant Source of Amyloid-β in Alzheimer's Disease?
The early stages of Alzheimer’s disease are characterized by rising levels of amyloid-β in the brain and the formation of misfolded amyloid aggregates. It is presently thought that this is a necessary precursor for the more harmful later stages of the condition, in which chronic inflammation and tau aggregation cause widespread cell death in the brain. It has been noted that amyloid-β exists outside the brain, and there is evidence for levels of amyloid-β in the vasculature to be in dynamic equilibrium with amyloid-β in the brain. <a href="https://www.fightaging.org/archives/2018/10/a-phase-iii-trial-based-on-the-peripheral-a…