Source https://www.fightaging.org/archives/2023/03/misfolded-proteins-accumulate-with-age-in-nematodes-and-mice/
In order to function correctly, proteins must form a specific folded structure after assembly from amino acids in a ribosome. This folding doesn’t always work as it should, and there is naturally some rate of error for processes taking place in the crowded, organized chaos of a cell interior. Protein misfolding leads to non-functional, sometimes toxic molecules. In the worst case scenario, with only a handful of proteins in the body being capable of this, a misfolded protein can encourage other molecules of the same protein to also misfold, and join into solid aggregates. Beyond this, a given error rate in folding across all proteins produced by a cell puts stress on that cell, and is addressed by a variety of quality control and housekeeping mechanisms that flag and recycle such mistakes when they occur.
To what degree is the burden of misfolded proteins an im…
Source https://www.fightaging.org/archives/2023/03/misfolded-proteins-accumulate-with-age-in-nematodes-and-mice/
In order to function correctly, proteins must form a specific folded structure after assembly from amino acids in a ribosome. This folding doesn’t always work as it should, and there is naturally some rate of error for processes taking place in the crowded, organized chaos of a cell interior. Protein misfolding leads to non-functional, sometimes toxic molecules. In the worst case scenario, with only a handful of proteins in the body being capable of this, a misfolded protein can encourage other molecules of the same protein to also misfold, and join into solid aggregates. Beyond this, a given error rate in folding across all proteins produced by a cell puts stress on that cell, and is addressed by a variety of quality control and housekeeping mechanisms that flag and recycle such mistakes when they occur.
To what degree is the burden of misfolded proteins an im…
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