mTORC1 Inhibition in Neurons Only Extends Life in Nematode Worms

Source https://www.fightaging.org/archives/2023/10/mtorc1-inhibition-in-neurons-only-extends-life-in-nematode-worms/

General inhibition of mTOR slows aging, a calorie restriction mimetic effect, but comes with a range of side-effects, given that mTOR is a regulator of growth and development. mTOR forms two different protein complexes, mTORC1 and mTORC2. In recent years, work to produce drugs based on mTOR inhibition has focused on selectively inhibiting mTORC1 in order to reduce side-effects. Researchers here report further reduction in side-effects in short-lived nematode worms by restricting mTORC1 inhibition to neurons only.

mTORC1 (mechanistic target of r…

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