Osteopontin is Involved in Macrophage Senescence in Aging Fat Tissue

Source https://www.fightaging.org/archives/2023/05/osteopontin-is-involved-in-macrophage-senescence-in-aging-fat-tissue/

Visceral fat tissue generates inflammation through a range of mechanisms, and this only becomes worse with advancing age. The more visceral fat tissue, the worse the long-term consequences for metabolism, driven by inflammatory signaling. One of these mechanisms is that fat tissue provokes a greater burden of cellular senescence, cells that shut down replication and focus their energies on generating disruptive pro-inflammatory signals. This tendency increases with age.

Today’s open access paper f…

Source https://www.fightaging.org/archives/2023/05/osteopontin-is-involved-in-macrophage-senescence-in-aging-fat-tissue/

Visceral fat tissue generates inflammation through a range of mechanisms, and this only becomes worse with advancing age. The more visceral fat tissue, the worse the long-term consequences for metabolism, driven by inflammatory signaling. One of these mechanisms is that fat tissue provokes a greater burden of cellular senescence, cells that shut down replication and focus their energies on generating disruptive pro-inflammatory signals. This tendency increases with age.

Today’s open access paper f…

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