PGC-1α4 Gene Therapy Reduces Sarcopenia and Metabolic Disease in Aged Mice

Source https://www.fightaging.org/archives/2023/08/pgc-1%CE%B14-gene-therapy-reduces-sarcopenia-and-metabolic-disease-in-aged-mice/

Researchers here demonstrate that aged muscle metabolism can be improved via gene therapy to deliver a short isoform of PGC-1α. Upregulating PGC-1α in muscle tissue is suggested to be a good approach to therapy based on its declining expression with age. It is interesting that the researchers focus on an isoform of the protein shown to be upregulated in exercise, in effect aiming to produce an exercise mimetic gene therapy that switches on one of the reactions to exercise and leaves it switched on indefinitely.

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Source https://www.fightaging.org/archives/2023/08/pgc-1%CE%B14-gene-therapy-reduces-sarcopenia-and-metabolic-disease-in-aged-mice/

Researchers here demonstrate that aged muscle metabolism can be improved via gene therapy to deliver a short isoform of PGC-1α. Upregulating PGC-1α in muscle tissue is suggested to be a good approach to therapy based on its declining expression with age. It is interesting that the researchers focus on an isoform of the protein shown to be upregulated in exercise, in effect aiming to produce an exercise mimetic gene therapy that switches on one of the reactions to exercise and leaves it switched on indefinitely.

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