Red Blood Cell Metabolic Waste Accumulates in the Aged Spleen to Harm T Cell Function

Source https://www.fightaging.org/archives/2025/11/red-blood-cell-metabolic-waste-accumulates-in-the-aged-spleen-to-harms-t-cell-function/

Researchers here report a novel mechanisms by which aging impairs the immune system. The spleen is an immune organ, an important location where immune cells congregate to communicate with one another and coordinate the immune response to pathogens. The spleen is also responsible for filtering damaged and worn red blood cells from the circulation. Unfortunately the aged spleen accumulates too much iron and metabolic waste as a result of reduced efficiency in clearing out those unwanted red blood cells. Exposure to this aged spleen environment is here shown to degrade the efficacy of T cells of the adaptive immune system.

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Source https://www.fightaging.org/archives/2025/11/red-blood-cell-metabolic-waste-accumulates-in-the-aged-spleen-to-harms-t-cell-function/

Researchers here report a novel mechanisms by which aging impairs the immune system. The spleen is an immune organ, an important location where immune cells congregate to communicate with one another and coordinate the immune response to pathogens. The spleen is also responsible for filtering damaged and worn red blood cells from the circulation. Unfortunately the aged spleen accumulates too much iron and metabolic waste as a result of reduced efficiency in clearing out those unwanted red blood cells. Exposure to this aged spleen environment is here shown to degrade the efficacy of T cells of the adaptive immune system.

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