Reducing the T Cell Exhaustion Caused by Cancer

Source https://www.fightaging.org/archives/2022/07/reducing-the-t-cell-exhaustion-caused-by-cancer/

Cancers employ a range of mechanisms to subvert and suppress the activities of immune cells attempting to destroy cancerous cells. One issue that appears inherent to T cells of the adaptive immune system, however, is the exhaustion that sets in following repeated exposure to molecules present on cancerous cells or in the tumor environment that trigger T cell receptors. This is how T cells identify targets. Individual T cells are initially effective at killing cancerous cells after T cell receptor interactions, but then become increasingly less effective over time. Can this be prevented? Potentially yes, but the processes involved are not simple, as researchers here explain.

The T cells found in the human immune system are some of the front-line soldiers in recognizing, attac…

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