A few different approaches have been proposed to clear advanced glycation endproducts (AGEs) from the lens of the eye, where they build up with age to make the lens stiffer. That stiffness results from cross-linking of extracellular matrix molecules by AGEs, restricting their ability to move relative to one another, and thus changing the structural properties of thetissue. That in turn leads to presbyopia as the muscles of the eye can no longer produce the desired changes to the lens needed to focus on near objects. Sadly, the most advanced program of cross-link breaking for the eye, <a href="https://www.fightaging.org/archives/2019/08/clinical-trial-of-a-cross-link-breaker-to-…
Removing AGEs from the Lens of the Eye to Treat Presbyopia
A few different approaches have been proposed to clear advanced glycation endproducts (AGEs) from the lens of the eye, where they build up with age to make the lens stiffer. That stiffness results from cross-linking of extracellular matrix molecules by AGEs, restricting their ability to move relative to one another, and thus changing the structural properties of thetissue. That in turn leads to presbyopia as the muscles of the eye can no longer produce the desired changes to the lens needed to focus on near objects. Sadly, the most advanced program of cross-link breaking for the eye, <a href="https://www.fightaging.org/archives/2019/08/clinical-trial-of-a-cross-link-breaker-to-…