Responses to Age-Slowing Interventions Differ by Organ and Gender

Source https://www.fightaging.org/archives/2021/09/responses-to-age-slowing-interventions-differ-by-organ-and-gender/

Once one starts to investigate, tissue type by tissue type, the effects of interventions known to modestly slow aging, one finds differences. This could be a matter of differences in the biodistribution of a particular therapeutic agent, or it could be that various forms of age-related damage are more or less significant in different organs, or that the regulation of stress responses differs from tissue to tissue, such that some therapeutics target a regulatory pathway more relevant to a kidney than a lung, for example. All of this implies that great deal of work lies ahead, if every potential therapy must be mapped by its effects on every type of tissue in the body, and optimization proceeds tissue type by tissue type.

The ability to study and compare organ aging in the context of organismal aging has recently been documented using a geropathology approach. This concept consists of identifying…

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