Something to bear in mind about aging is that while there is a good catalog of mechanisms and processes, it is rarely clear as to how much of any specific manifestation of degenerative aging is due to process A versus process B. The only way to find out is to remove or repair one of the mechanisms of aging in isolation, and see what results. Until quite recently, the only tools that could change the pace of aging involved upregulation of stress response mechanisms, such as via calorie restriction. These approaches produce sweeping changes in metabolism and all processes related to aging. Now, however, senolytic drugs allow researchers to remove only the contribution of senescent cells to aging, and that such a technology exists is the only reason that we know anything about the…
Reviewing the Contribution of Cellular Senescence to Skin Aging
Something to bear in mind about aging is that while there is a good catalog of mechanisms and processes, it is rarely clear as to how much of any specific manifestation of degenerative aging is due to process A versus process B. The only way to find out is to remove or repair one of the mechanisms of aging in isolation, and see what results. Until quite recently, the only tools that could change the pace of aging involved upregulation of stress response mechanisms, such as via calorie restriction. These approaches produce sweeping changes in metabolism and all processes related to aging. Now, however, senolytic drugs allow researchers to remove only the contribution of senescent cells to aging, and that such a technology exists is the only reason that we know anything about the…