Senolytics as a Therapy for Disc Degeneration Leading to Back Pain

Source https://www.fightaging.org/archives/2025/04/senolytics-as-a-therapy-for-disc-degeneration-leading-to-back-pain/

A growing body of work implicates the accumulation of senescent cells in degeneration of function and structure in the discs that separate vertebrae in the spine. This is a prevalent issue, causing pain and loss of function. The ability to restore lost function is limited at best, but clearance of senescent cells via senolytic drugs has shown promise in animal studies of degenerative disc disorders. Here, researchers employ a novel senolytic approach to produce beneficial outcomes in mice.

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