Targeted Protein Degradation as an Approach to Treatment

Source https://www.fightaging.org/archives/2023/03/targeted-protein-degradation-as-an-approach-to-treatment/

Targeted protein degradation is a term that covers a range of possible approaches to more selectively removing specific modified proteins from cells than has traditionally been possible. Researchers here provide an example of this type of work, targeting a modification of p38 in the context of Alzheimer’s disease. This is a good illustration of the capabilities of this class of therapy, but probably not the best illustration of a good target: this still seems like a matter of messing with metabolism made dysfunctional by damage rather than targeting the underlying damage itself for repair.

Recent progress in the field of targeted protein degradation (TPD) has proven its immense potential …

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