Tau Aggregation Drives Neuroinflammation via Transposable Element Activation

Source https://www.fightaging.org/archives/2023/01/tau-aggregation-drives-neuroinflammation-via-transposable-element-activation/

Evidence suggests that there is a bidirectional relationship between tau aggregation and inflammation in the aging brain. Both occur in all brains, and when present to a greater degree contribute to the neurodegenerative conditions termed tauopathies. The most well known of these is Alzheimer’s disease, in which tau aggregates and their surrounding toxic biochemistry cause the widespread cell death and severe symptoms that characterize the final stages of the condition.

Various studies individually support each of the two directions of the relationship between tau and inflammation. <a href="https://www.fightaging.org/archives/2018/08/clearing-senescent-cells-from-the…

Source https://www.fightaging.org/archives/2023/01/tau-aggregation-drives-neuroinflammation-via-transposable-element-activation/

Evidence suggests that there is a bidirectional relationship between tau aggregation and inflammation in the aging brain. Both occur in all brains, and when present to a greater degree contribute to the neurodegenerative conditions termed tauopathies. The most well known of these is Alzheimer’s disease, in which tau aggregates and their surrounding toxic biochemistry cause the widespread cell death and severe symptoms that characterize the final stages of the condition.

Various studies individually support each of the two directions of the relationship between tau and inflammation. <a href="https://www.fightaging.org/archives/2018/08/clearing-senescent-cells-from-the…

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