The authors of this open access papers discuss the prominent role of cell signaling in the better known classes of intervention that have been shown to slow aging in worms, flies, and mice. The body is a network in which cells in one tissue influence the behavior of cells in other tissues via the signal molecules and vesicles that they secrete into the circulatory system. This leads to a focus on mimicking these signals, such as in the production of calorie restriction mimetics and exercise mimetics. As an approach to extending healthy life span, this seems likely to be bounded in effectiveness by the present natural …
The Body is a Network: Cell Signaling in Age-Slowing Interventions
The authors of this open access papers discuss the prominent role of cell signaling in the better known classes of intervention that have been shown to slow aging in worms, flies, and mice. The body is a network in which cells in one tissue influence the behavior of cells in other tissues via the signal molecules and vesicles that they secrete into the circulatory system. This leads to a focus on mimicking these signals, such as in the production of calorie restriction mimetics and exercise mimetics. As an approach to extending healthy life span, this seems likely to be bounded in effectiveness by the present natural …