Atherosclerosis is a condition of dysfunctional macrophages. The innate immune cells called macrophages are responsible for removing cholesterol from blood vessel walls, where it lodges, carried by LDL particles. The macrophages ingest cholesterol and hand it off to HDL particles that carry it back to the liver for excretion. Macrophages exhibit packages of behaviors called polarizations, and this cleaning up…
The Senescence-Associated Secretory Phenotype as an Important Mechanism in Atherosclerosis
Atherosclerosis is a condition of dysfunctional macrophages. The innate immune cells called macrophages are responsible for removing cholesterol from blood vessel walls, where it lodges, carried by LDL particles. The macrophages ingest cholesterol and hand it off to HDL particles that carry it back to the liver for excretion. Macrophages exhibit packages of behaviors called polarizations, and this cleaning up…