A small number of low-cost and generic drugs have extensive human use and safety data, but also a sizable, compelling body of animal study evidence to suggest a likely modest slowing of aging, e.g. rapamycin, or that demonstrates the ability to target a mechanism of aging to reverse age-related disease, e.g. the dasatinib and quercetin, shown to selectively destroy senescent cells. In the US any drug approved for a given use can also be used off-label to treat other conditions. In principle the drug can be prescribed by any physician in this way. This is legal, though tends to require a slow bootstrapping process of education, physician acceptance, grad…
The Slow Spread of Off-Label Use for Treatments Shown to Target Mechanisms of Aging
A small number of low-cost and generic drugs have extensive human use and safety data, but also a sizable, compelling body of animal study evidence to suggest a likely modest slowing of aging, e.g. rapamycin, or that demonstrates the ability to target a mechanism of aging to reverse age-related disease, e.g. the dasatinib and quercetin, shown to selectively destroy senescent cells. In the US any drug approved for a given use can also be used off-label to treat other conditions. In principle the drug can be prescribed by any physician in this way. This is legal, though tends to require a slow bootstrapping process of education, physician acceptance, grad…