The immune system of the central nervous system is distinct from that of the rest of the body, although there is a great deal of direct and indirect cross-talk between the two. The innate immune cells known as microglia are the central nervous system version of macrophages, and are involved in defense against pathogens, clearance of metabolic waste, and aspects of the normal function of brain tissue, such as maintenance of synaptic connections between neurons. With age, microglia become increasingly inflammatory, and many lines of evi…
Tim-3 Inhibition in Microglia Encourages Amyloid Clearance in the Brain
The immune system of the central nervous system is distinct from that of the rest of the body, although there is a great deal of direct and indirect cross-talk between the two. The innate immune cells known as microglia are the central nervous system version of macrophages, and are involved in defense against pathogens, clearance of metabolic waste, and aspects of the normal function of brain tissue, such as maintenance of synaptic connections between neurons. With age, microglia become increasingly inflammatory, and many lines of evi…