Source https://www.fightaging.org/archives/2022/01/towards-a-better-understanding-of-osteoclasts-in-osteoporosis/
Bone is, despite appearances, a very dynamic tissue. Bone structure is constantly remodeled, and a balance between the activities of osteoblasts that create bone extracellular matrix and osteoclasts that break down that matrix is necessary to maintain healthy, functional bones. With advancing age this balance is disrupted, shifting to favor osteoclast activity over osteoblast activity. Bones become weaker, less dense, and fragile, leading to osteoporosis and serious, life-limiting fracture events.
Given that osteoporosis is an imbalance, there are numerous possible approaches to the development of therapies. Identifying and removing the fundamental causes of reduced osteoblast activity or increased osteoclast activity would be the most likely to succeed. This means reversing or repairing the cau…
Source https://www.fightaging.org/archives/2022/01/towards-a-better-understanding-of-osteoclasts-in-osteoporosis/
Bone is, despite appearances, a very dynamic tissue. Bone structure is constantly remodeled, and a balance between the activities of osteoblasts that create bone extracellular matrix and osteoclasts that break down that matrix is necessary to maintain healthy, functional bones. With advancing age this balance is disrupted, shifting to favor osteoclast activity over osteoblast activity. Bones become weaker, less dense, and fragile, leading to osteoporosis and serious, life-limiting fracture events.
Given that osteoporosis is an imbalance, there are numerous possible approaches to the development of therapies. Identifying and removing the fundamental causes of reduced osteoblast activity or increased osteoclast activity would be the most likely to succeed. This means reversing or repairing the cau…
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