Author: Tom

Source https://www.fightaging.org/archives/2025/12/high-variance-in-individual-responses-is-another-complexity-in-attempting-to-slow-aging-via-metabolic-manipulation/

Evolution produces species that exhibit stochastic metabolic variation from individual to individual. Any species or subpopulation of a given species lacking this individual variation might be more successful in a specific ecological niche, but would vanish due to competition the moment that niche changed in any way. And change is a feature of the world we live in. Given a long enough time scale, everything shifts in character. The species we see today are the descendants of the survivors of change, that survival enabled by individual metabolic variation within the species.

This adds to the growing list of complexities faced by any group attempting to find…

Source https://seniorplanet.org/articles-stay-fit-while-traveling/

Is it possible to maintain healthy habits while on vacation? Sponsored Athlete Steven says “Yes!” – and shares helpful tips for older adults on the go.

The post How To Stay Fit While Traveling appeared first on Senior Planet from AARP.

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Source https://www.nerdfitness.com/blog/short-on-time/

We’re officially in that stretch of the year where it feels like someone hit the chaos button: work deadlines, school events, holiday travel…all happening at once.

And in the middle of that, trying to follow a “normal” workout routine can feel impossible.

Luckily, you don’t need to!

Here are three strategies we use with busy coaching clients to get great results without workouts having to take over their lives.

Pick one and plug it in whenever your schedule tightens up. <img src="https://s.w.org/images/core/emoji/16.0.1/72×72/1f4aa.png" alt="💪" class="wp-smiley" style="heigh…

Source https://tinybuddha.com/blog/what-finally-helped-me-break-free-from-constant-food-noise/

“Between stimulus and response there is a space. In that space is our power to choose our response.” ~Viktor Frankl

For years, I thought something was wrong with me.

No matter what I was doing—sitting in a meeting, walking the dog, or watching TV—my brain was busy debating food.

Should I eat? Shouldn’t I? I could just have one more bite, couldn’t I? What should I eat next? I’ve blown it today, haven’t I? I’ve failed again. Shall I just eat whatever I want and start again tomorrow?

The chatter was constant. It left me exhausted, ashamed, and convinced that I was weak.

I told myself it was a lack of willpower. If…

Source https://seniorplanet.org/articles-senior-planet-glenn-close/

Senior Planet talks to icon Glenn Close, 78, about her role in Wake Up Dead Man: A Knives Out Mystery, and her very personal addition to her costume.

The post Senior Planet talks to…Glenn Close appeared first on Senior Planet from AARP.

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Source https://www.theminimalists.com/enjoy/

The Minimalists talk about why people buy so many gifts that their loved ones don’t actually enjoy.

What’s one gift you don’t enjoy getting? Let us know in the YouTube comments.

The post Gifts That Loved Ones Don’t Actually Enjoy appeared first on The Minimalists.

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Source https://tinybuddha.com/blog/5-surefire-signs-you-grew-up-with-an-emotionally-immature-parent/

“There’s no such thing as a ‘bad kid’—just angry, hurt, tired, scared, confused, impulsive ones expressing their feelings and needs the only way they know how. We owe it to every single one of them to always remember that.” ~Dr. Jessica Stephens 

All children look up to their parents from the moment they enter this world. They have this beautiful, pure, unconditional love pouring out of them. Parents are on a pedestal. They are the ones who know what’s best! They are the grownups showing us how to do life!

We don’t think for one moment that they could be showing us the wrong way.

I, like many others, adored both my mum and dad. I could not see their flaws, their pains, or their trauma. I just loved them and wanted to spend time with them. If they…

Source https://www.fightaging.org/archives/2025/12/mechanosensing-in-monocytes-and-macrophages-induces-scar-tissue-formation/

Scar tissue is formed by excess deposition of extracellular matrix molecules such as collagen. It obstructs complete healing. In aged tissues, fibrosis is a form of inappropriate scarring and consequent loss of function produced by the disruption of normal tissue maintenance. Researchers here provide evidence for scarring following injury to be driven by a subpopulation of monocytes and macrophages, types of myeloid immune cell. The pro-fibrotic behavior of these cells is triggered by mechanical cues. Mechanosensing is a complex set of regulatory pathways by which cells react to the mechanical pr…

Source https://www.fightaging.org/archives/2025/12/butyrate-generated-by-gut-microbes-is-senomorphic-in-t-cells/

Butyrate is one of the better known metabolites generated by microbial populations within the gut microbiome, a product of the fermentation of dietary fiber. Butyrate has been shown to produce beneficial effects in a range of tissues, such as via increased BDNF signaling to improve brain and muscle health. Production of butyrate declines with age, a consequence of harmful shifts in the composition of the gut microbiome that t…

Source https://www.fightaging.org/archives/2025/12/ubqln2-is-important-in-the-aggregation-of-%CE%B1-synuclein-in-neurodegenerative-conditions/

The chemistry of molecules in solution is dynamic and complex, such as the spontaneous liquid-liquid phase separation in which a solution divides into regions of greater and lesser concentrations to form droplets. This process is important in the formation of protein aggregates involved in neurodegenerative disease. Here, researchers show that the α-synuclein that misfolds and aggregates to cause Parkinson’s disease does not undergo liquid-liquid phase separation on its own, but rather is dragged into the liquid-liquid phase separation and droplet formation of another protein, …