Source https://www.fightaging.org/archives/2025/11/mitochondrial-protein-chchd2-in-parkinsons-disease/
Parkinson’s disease is a considered to be caused by misfolding and aggregation of α-synuclein, a particularly pernicious malfunction of protein structure that can spread from cell to cell like a prion, encouraging other molecules of α-synuclein to also misfold in the same way. Mitochondria are prominently involved in Parkinson’s disease because forms of impairment to mitochondrial function, whether by aging or inherited mutation, make the motor neurons in the brain that are already most vulnerable to death due to α-synuclein pathology even more vulnerable to that fate. Here, howeve…
Source https://www.fightaging.org/archives/2025/11/mitochondrial-protein-chchd2-in-parkinsons-disease/
Parkinson’s disease is a considered to be caused by misfolding and aggregation of α-synuclein, a particularly pernicious malfunction of protein structure that can spread from cell to cell like a prion, encouraging other molecules of α-synuclein to also misfold in the same way. Mitochondria are prominently involved in Parkinson’s disease because forms of impairment to mitochondrial function, whether by aging or inherited mutation, make the motor neurons in the brain that are already most vulnerable to death due to α-synuclein pathology even more vulnerable to that fate. Here, howeve…
Source https://www.fightaging.org/archives/2025/11/red-blood-cell-metabolic-waste-accumulates-in-the-aged-spleen-to-harms-t-cell-function/
Researchers here report a novel mechanisms by which aging impairs the immune system. The spleen is an immune organ, an important location where immune cells congregate to communicate with one another and coordinate the immune response to pathogens. The spleen is also responsible for filtering damaged and worn red blood cells from the circulation. Unfortunately the aged spleen accumulates too much iron and metabolic waste as a result of reduced efficiency in clearing out those unwanted red blood cells. Exposure to this aged spleen environment is here shown to degrade the efficacy of T cells of the adaptive immune system.
<…
Source https://www.fightaging.org/archives/2025/11/red-blood-cell-metabolic-waste-accumulates-in-the-aged-spleen-to-harms-t-cell-function/
Researchers here report a novel mechanisms by which aging impairs the immune system. The spleen is an immune organ, an important location where immune cells congregate to communicate with one another and coordinate the immune response to pathogens. The spleen is also responsible for filtering damaged and worn red blood cells from the circulation. Unfortunately the aged spleen accumulates too much iron and metabolic waste as a result of reduced efficiency in clearing out those unwanted red blood cells. Exposure to this aged spleen environment is here shown to degrade the efficacy of T cells of the adaptive immune system.
<…
Source https://www.fightaging.org/archives/2025/11/the-myokine-cathepsin-b-improves-cognitive-function-in-an-alzheimers-mouse-model/
Muscle tissue is metabolically active, particularly following exercise, in ways that improve function in other tissues. As a class, molecules secreted by muscle cells that affect other tissues are called myokines, and are not presently fully mapped and understood. The research community is actively engaged in identifying myokines and myokine interactions that could be targets for novel therapies that mimic some of the benefits of exercise. Here, researchers show that increased levels of the myokine cathepsin B can reduce the loss of function in the brain that occurs in a mouse model of Alzheimer’s disease. Interestingly, this same treatment impairs cognitive function in normal mice, indicating that (a) there can be too much of this myokine in circulation…
Source https://www.fightaging.org/archives/2025/11/the-myokine-cathepsin-b-improves-cognitive-function-in-an-alzheimers-mouse-model/
Muscle tissue is metabolically active, particularly following exercise, in ways that improve function in other tissues. As a class, molecules secreted by muscle cells that affect other tissues are called myokines, and are not presently fully mapped and understood. The research community is actively engaged in identifying myokines and myokine interactions that could be targets for novel therapies that mimic some of the benefits of exercise. Here, researchers show that increased levels of the myokine cathepsin B can reduce the loss of function in the brain that occurs in a mouse model of Alzheimer’s disease. Interestingly, this same treatment impairs cognitive function in normal mice, indicating that (a) there can be too much of this myokine in circulation…
Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-december-1st-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-december-1st-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/11/age-specific-anti-aging-interventions-as-another-example-of-the-undesirable-complexity-of-altering-metabolism/
Metabolism is exceedingly complex, and incompletely understood. This is true of individual cells, let alone organisms made up of very large numbers of those cells. Most of the work done on interventions intended to slow aging takes the form of attempts to alter metabolism into a more favorable state in which aging progresses at a modestly slower pace, usually via the use of small molecules. This approach is doomed to failure at this stage of technological progress. We do not know enough of metabolism, we cannot control enough of metabolism. Studies show that combining any two marginally aging-slowing small molecules is as likely as not to produce an interaction that results in a marginal acceleration of aging. Similarly, researchers here d…
Source https://www.fightaging.org/archives/2025/11/age-specific-anti-aging-interventions-as-another-example-of-the-undesirable-complexity-of-altering-metabolism/
Metabolism is exceedingly complex, and incompletely understood. This is true of individual cells, let alone organisms made up of very large numbers of those cells. Most of the work done on interventions intended to slow aging takes the form of attempts to alter metabolism into a more favorable state in which aging progresses at a modestly slower pace, usually via the use of small molecules. This approach is doomed to failure at this stage of technological progress. We do not know enough of metabolism, we cannot control enough of metabolism. Studies show that combining any two marginally aging-slowing small molecules is as likely as not to produce an interaction that results in a marginal acceleration of aging. Similarly, researchers here d…
Source https://www.fightaging.org/archives/2025/11/air-pollution-increases-the-pace-of-loss-of-muscle-mass-and-strength-with-age/
A large body of evidence indicates that forms of air pollution harm long-term health. This is largely epidemiological data, observing correlations with incidence of mortality and age-related disease in populations exposed to different levels of pollutants. A number of regions of the world exhibit, through happenstance, very similar populations that are exposed to significantly different levels of particulate and chemical pollutants. Consider studies covering the Puget Sound in the US or parts of China. These natural …
Source https://www.fightaging.org/archives/2025/11/air-pollution-increases-the-pace-of-loss-of-muscle-mass-and-strength-with-age/
A large body of evidence indicates that forms of air pollution harm long-term health. This is largely epidemiological data, observing correlations with incidence of mortality and age-related disease in populations exposed to different levels of pollutants. A number of regions of the world exhibit, through happenstance, very similar populations that are exposed to significantly different levels of particulate and chemical pollutants. Consider studies covering the Puget Sound in the US or parts of China. These natural …
Source https://www.fightaging.org/archives/2025/11/arginine-as-a-chaperone-to-reduce-amyloid-%CE%B2-aggregation/
The amino acid arginine has been shown to act as a chaperone, or improve the ability of existing chaperone molecules to reduce aggregation of misfolded proteins such as the amyloid-β associated with the development of Alzheimer’s disease. Researchers here supplement the diets of mice with sizable doses of arginine in order to produce effects on amyloid-β aggregation; the equivalent dose in humans would be something like 1 gram per kilogram of body weight, daily. One caveat is that the mouse model of Alzheimer’s used here is relevant to <a href="https://en.wikipedia.org/wiki/Early-ons…
Source https://www.fightaging.org/archives/2025/11/arginine-as-a-chaperone-to-reduce-amyloid-%CE%B2-aggregation/
The amino acid arginine has been shown to act as a chaperone, or improve the ability of existing chaperone molecules to reduce aggregation of misfolded proteins such as the amyloid-β associated with the development of Alzheimer’s disease. Researchers here supplement the diets of mice with sizable doses of arginine in order to produce effects on amyloid-β aggregation; the equivalent dose in humans would be something like 1 gram per kilogram of body weight, daily. One caveat is that the mouse model of Alzheimer’s used here is relevant to <a href="https://en.wikipedia.org/wiki/Early-ons…
Source https://www.theminimalists.com/plaque/
The Minimalists disagree with each other about what to do with their YouTube plaque.
Do you think we should we donate our YouTube Play Button? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Decluttering Our YouTube Plaque appeared first on The Minimalists.
…
Source https://www.theminimalists.com/plaque/
The Minimalists disagree with each other about what to do with their YouTube plaque.
Do you think we should we donate our YouTube Play Button? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Decluttering Our YouTube Plaque appeared first on The Minimalists.
…
Source https://www.theminimalists.com/silence/
By T.K. Coleman
I recently attended a silent retreat at a monastery.
At one point, while sitting outside in meditation, I saw a beautiful image hanging on the wall of a chapel. My immediate thought was: I should take a picture of that and share it on social media.
As I reached for my phone, I paused and asked myself:
“Do I ignore my phone and continue to bask in the richness of this silence?”
Or…
“Do I…
Source https://www.theminimalists.com/silence/
By T.K. Coleman
I recently attended a silent retreat at a monastery.
At one point, while sitting outside in meditation, I saw a beautiful image hanging on the wall of a chapel. My immediate thought was: I should take a picture of that and share it on social media.
As I reached for my phone, I paused and asked myself:
“Do I ignore my phone and continue to bask in the richness of this silence?”
Or…
“Do I…
Source https://tinybuddha.com/blog/the-unexpected-therapy-i-found-on-my-phone/
“Sometimes you will never know the value of a moment until it becomes a memory.” ~Dr. Seuss
The notification pops up on my phone: “Jason, we made a new memory reel for you.” I pause whatever I’m doing, probably something stressful involving deadlines or dishes, and feel that familiar flutter of excitement. What chapter of my life has Google decided to surprise me with today?
I tap the notification, and suddenly I’m watching years of Father’s Day adventures unfold. It started accidentally—one Father’s Day trip to the Buffalo Zoo that somehow became our tradition. Instead of buying me something I didn’t really need, we chose experiences. Year after year, we’d visit…
Source https://tinybuddha.com/blog/the-unexpected-therapy-i-found-on-my-phone/
“Sometimes you will never know the value of a moment until it becomes a memory.” ~Dr. Seuss
The notification pops up on my phone: “Jason, we made a new memory reel for you.” I pause whatever I’m doing, probably something stressful involving deadlines or dishes, and feel that familiar flutter of excitement. What chapter of my life has Google decided to surprise me with today?
I tap the notification, and suddenly I’m watching years of Father’s Day adventures unfold. It started accidentally—one Father’s Day trip to the Buffalo Zoo that somehow became our tradition. Instead of buying me something I didn’t really need, we chose experiences. Year after year, we’d visit…
