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Source https://www.fightaging.org/archives/2025/12/a-glp-1-receptor-agonist-fails-to-slow-alzheimers-disease-in-a-phase-3-trial/

On the one hand there is a modest amount of evidence for GLP-1 receptor agonist drugs to produce beneficial effects on an aged metabolism that are unconnected to weight loss. On the other hand, when Big Pharma has a very successful drug, it will attempt to use that drug for every condition it can that is associated with a sizable market, whether or not the expected effects are marginal. So it isn’t necessarily indicative of support for these non-weight-loss mechanisms that leads the clinical trial of a weight loss drug for patients with Alzheimer’s disease. Cynically, it is that Alzheimer’s is an enormous market.

The <a href="https://www.fightaging.org/archives/2014/11/the-ridiculous-cost-of-medical-research-regula…

Source https://www.ageinplacetech.com/blog/will-ai-enable-just-time-delivery-boomer-safety-bundle-80

Source https://www.theminimalists.com/5-sneaky-ways-stores-get-you-to-spend-money-on-stuff-you-dont-need/

The Minimalists discuss sneaky tricks retail stores use to get people to spend money.

What’s the last purchase you made that you didn’t need? Let us know in the YouTube comments.

The post 5 Sneaky Ways Stores Get You to Spend Money on Stuff You Don’t Need appeared first on The Minimalists.

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Source https://tinybuddha.com/blog/work-is-not-family-a-lesson-i-never-wanted-but-need-to-share/

“The paradox of trauma is that it has both the power to destroy and the power to transform and resurrect.” ~Peter Levine

I was sitting in the conference room at work with the CEO and my abusive male boss.

The same boss who had been love-bombing and manipulating me since I started nine months earlier, slowly pushing my nervous system into a constant state of fight-or-flight.

When I was four months into the job, this boss went on a three-day bender during an overnight work conference at a fancy hotel in Boston.

He skipped client meetings or showed up smelling like alcohol, wearing yesterday’s clothes.

When I texted…

Source https://www.fightaging.org/archives/2025/12/the-state-of-il-10-signaling-may-be-important-in-the-aging-of-hematopoietic-stem-cells/

Stem cells exist in order to minimize the number of cells capable of unrestricted replication; most cells in the body are limited in the number of times that they can divide. This limit serves to reduce the risk of cancer – and other severe disruptions that could result from unlimited replication of a malfunctioning cell – to an acceptably low level to enable evolutionary success. Stem cells provide a supply of daughter somatic cells to replace those that are lost over time, due to limited somatic cell replication. In actuality, stem cells spend much of their time in a state of quiescence, without replicating. This is necessary to preserve their function and minimize damage over the course of a lifetime. When forced into excessive activity, stem cells risk …

Source https://www.theminimalists.com/adsense/

The Minimalists were shocked to find out that YouTube put ads on their channel.

How do you opt out of advertisements? Let us know in the YouTube comments.

The post YouTube started putting ads on our videos without permission… appeared first on The Minimalists.

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Source https://www.fightaging.org/archives/2025/12/lysosomal-dysfunction-via-acidification-drives-hematopoietic-stem-cell-aging/

Lysosomes are a vital component in the recycling systems of the cell, organelles that break down harmful or unwanted molecules in order to provide raw materials for manufacture of new molecules. As is the case for all cell components, lysosomes become dysfunctional with age. The buildup of persistent metabolic waste, such as lipofuscin, that cells struggle to break down is implicated in age-related lysosomal dysfunction in long-lived cells, such as neurons. Sweeping epigenetic and transcriptomic changes that alter the production of proteins occur with age in all cells, and it is likely that a subset of these changes …

Source https://tinybuddha.com/blog/letting-go-of-the-life-you-were-told-to-want/

“To be yourself in a world that is constantly trying to make you something else is the greatest accomplishment.” ~Ralph Waldo Emerson

Ever since I was about four years old, I knew I was different from the other kids. I was always on the outside looking in. As I approach middle age, I’ve never shaken that feeling—the knowing—of being different.

We live in a noisy world where we find whatever we seek. If we’re looking for validation that we don’t belong, that’s exactly what we’ll find.

While flawed, th…

Source https://www.theminimalists.com/p516/

The Minimalists talk about being overwhelmed by other people’s clutter, dealing with hoarder family members, why a pound of experiences is worth more than a pound of Christmas gifts, five sneaky ways stores get you to spend money on stuff you don’t need, and much more.

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Source https://seniorplanet.org/articles-digital-holiday-shopping/

Modern tech tools make it easier than ever for older adults to snag the season’s best bargains from the comforts of home.

The post Click, Save, Celebrate – Happy Digital Holiday Shopping appeared first on Senior Planet from AARP.

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