Source https://www.fightaging.org/archives/2024/05/upregulation-of-cyclophilin-a-as-a-potential-path-to-improve-aged-hematopoietic-stem-cell-function/
Researchers here report on the importance of molecular chaperones, and cyclophilin A in particular, to the function of hematopoietic stem cells. These cells generate red blood cells and immune cells, and thus age-related changes in hematopoietic function have important consequences for health. The immune system runs awry with age, and altered hematopoiesis is one of the contributing factors. If, as researchers here suggest, upregulation of cyclophilin A can improve hematopoietic stem cell function, then using this as a basis for therapy may produce health benefits in older individuals.
<…
Source https://www.fightaging.org/archives/2024/05/upregulation-of-cyclophilin-a-as-a-potential-path-to-improve-aged-hematopoietic-stem-cell-function/
Researchers here report on the importance of molecular chaperones, and cyclophilin A in particular, to the function of hematopoietic stem cells. These cells generate red blood cells and immune cells, and thus age-related changes in hematopoietic function have important consequences for health. The immune system runs awry with age, and altered hematopoiesis is one of the contributing factors. If, as researchers here suggest, upregulation of cyclophilin A can improve hematopoietic stem cell function, then using this as a basis for therapy may produce health benefits in older individuals.
<…
Source https://greatist.com/health/planche
Learn how to master the planche, a high-level strength move that transforms your body into a floating plank.
Ready to defy gravity and impress onlookers with a stunning display of strength and balance? Enter the planche, a gymnastic feat that goes well beyond the average plank or push-up.
Mastering the planche means learning to float your body parallel to the ground, a dazzing trick worth the sweat.
But what exactly is a planche, and how can you achieve it? Let’s break down the essentials into five bite-sized pieces that’ll have you planching in no time.
What is a planche?
The planche is a gravity-defying marvel where you turn into a hum…
Source https://greatist.com/health/planche
Learn how to master the planche, a high-level strength move that transforms your body into a floating plank.
Ready to defy gravity and impress onlookers with a stunning display of strength and balance? Enter the planche, a gymnastic feat that goes well beyond the average plank or push-up.
Mastering the planche means learning to float your body parallel to the ground, a dazzing trick worth the sweat.
But what exactly is a planche, and how can you achieve it? Let’s break down the essentials into five bite-sized pieces that’ll have you planching in no time.
What is a planche?
The planche is a gravity-defying marvel where you turn into a hum…
Source https://www.fightaging.org/archives/2024/05/fight-aging-newsletter-may-13th-2024/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
Source https://www.fightaging.org/archives/2024/05/fight-aging-newsletter-may-13th-2024/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
Source https://www.fightaging.org/archives/2024/05/antiretroviral-drug-use-associated-with-lower-risk-of-alzheimers-disease/
Transposable elements in the genome are the remnants of ancient viral infections, capable of hijacking cellular machinery to copy themselves haphazardly across the genome, causing damage to existing genes. They can further provoke inflammation and cell dysfunction via the presence of the viral machinery that these transposable element sequences code for; innate immune mechanisms in cells have evolved to detect such apparently foreign molecules. Transposable elements are effectively suppressed in youth, but with age this suppression breaks down. It has been suggested that activation of transposable elements is an important contributing factor in age-related conditions, particularly in neurodegenerativ…
Source https://www.fightaging.org/archives/2024/05/antiretroviral-drug-use-associated-with-lower-risk-of-alzheimers-disease/
Transposable elements in the genome are the remnants of ancient viral infections, capable of hijacking cellular machinery to copy themselves haphazardly across the genome, causing damage to existing genes. They can further provoke inflammation and cell dysfunction via the presence of the viral machinery that these transposable element sequences code for; innate immune mechanisms in cells have evolved to detect such apparently foreign molecules. Transposable elements are effectively suppressed in youth, but with age this suppression breaks down. It has been suggested that activation of transposable elements is an important contributing factor in age-related conditions, particularly in neurodegenerativ…
Source https://www.fightaging.org/archives/2024/05/a-mismatch-between-central-versus-peripheral-circadian-regulation-in-aging/
Researchers here present an interesting view of age-related circadian dysfunction, focusing on mismatched regulation between the central circadian clock and somewhat independent peripheral clocks. The regulation of circadian rhythm in tissues results from the activities of these complex systems of multiple parts – and like all complex systems they begin to exhibit dysfunction with advancing age. The novel aspect of this research is the concept of multiple mismatched circadian regulators as a cause of further dysfunction in tissues.
Discovered in the 1970s, circadian clocks are essential for the regulation of biological time in most cells in the human body. These internal mechanisms adjust biological processe…
Source https://www.fightaging.org/archives/2024/05/a-mismatch-between-central-versus-peripheral-circadian-regulation-in-aging/
Researchers here present an interesting view of age-related circadian dysfunction, focusing on mismatched regulation between the central circadian clock and somewhat independent peripheral clocks. The regulation of circadian rhythm in tissues results from the activities of these complex systems of multiple parts – and like all complex systems they begin to exhibit dysfunction with advancing age. The novel aspect of this research is the concept of multiple mismatched circadian regulators as a cause of further dysfunction in tissues.
Discovered in the 1970s, circadian clocks are essential for the regulation of biological time in most cells in the human body. These internal mechanisms adjust biological processe…
Source https://www.fightaging.org/archives/2024/05/state-of-physical-fitness-is-a-reliable-predictor-of-age-related-mortality/
Being more physically fit at a given age reliably correlates with a lower future mortality risk. While human epidemiological data can only provide correlations, animal studies can and do provide evidence for physical fitness and exercise to modestly slow aspects of aging and reduce age-related mortality. In general, maintaining physical fitness into later life appears to be a good idea, based on the evidence.
Cardiorespiratory fitness (CRF) is a physical trait that reflects the integrated function of numerous bodily systems to deliver and use oxygen to support muscle activity during sustained, rhythmic, whole-body, large muscle physical activity. CRF can be objectively measured using direct (usually by maximal exercise testing with concomitant gas exchange analysis) …
Source https://www.fightaging.org/archives/2024/05/state-of-physical-fitness-is-a-reliable-predictor-of-age-related-mortality/
Being more physically fit at a given age reliably correlates with a lower future mortality risk. While human epidemiological data can only provide correlations, animal studies can and do provide evidence for physical fitness and exercise to modestly slow aspects of aging and reduce age-related mortality. In general, maintaining physical fitness into later life appears to be a good idea, based on the evidence.
Cardiorespiratory fitness (CRF) is a physical trait that reflects the integrated function of numerous bodily systems to deliver and use oxygen to support muscle activity during sustained, rhythmic, whole-body, large muscle physical activity. CRF can be objectively measured using direct (usually by maximal exercise testing with concomitant gas exchange analysis) …
Source https://seniorplanet.org/articles-trainer-kevin-tsan/
Kevin, brand new to Senior Planet, is bringing the Senior Planet curriculum to the Vietnamese-speaking population of Maryland!
The post Meet the Trainer: Kevin Tsan appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-trainer-kevin-tsan/
Kevin, brand new to Senior Planet, is bringing the Senior Planet curriculum to the Vietnamese-speaking population of Maryland!
The post Meet the Trainer: Kevin Tsan appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2024/05/promising-initial-results-from-a-phase-ii-trial-of-vegf-gene-therapy/
Intravenous, high-dose AAV gene therapy to upregulate VEGF has been shown to extend life in mice. This is perhaps a demonstration of the importance of loss of capillary density in tissue as a result of age-related disruption to angiogenesis, the multi-step process by which new blood vessels branch from existing vessels. Upregulation of VEGF is one of the possible approaches to restoring maintenance of capillary networks via improved angiogenesis, as VEGF is one of the important sig…
Source https://www.fightaging.org/archives/2024/05/promising-initial-results-from-a-phase-ii-trial-of-vegf-gene-therapy/
Intravenous, high-dose AAV gene therapy to upregulate VEGF has been shown to extend life in mice. This is perhaps a demonstration of the importance of loss of capillary density in tissue as a result of age-related disruption to angiogenesis, the multi-step process by which new blood vessels branch from existing vessels. Upregulation of VEGF is one of the possible approaches to restoring maintenance of capillary networks via improved angiogenesis, as VEGF is one of the important sig…
Source https://zenhabits.net/slow-retreat/
Our days are a busy rush, often from the moment we wake up. Even in our moments of rest, we are often on our phones or using technology to distract ourselves. The result is a life of stress, overwhelm, and habitual patterns.
What would it be like to slow down? To find stillness in your day, moments of rest and quietude?
The possibility of slowing down goes much deeper than just having a bit less busyness in your day …
Slowing down, if we go deeper, allows us to:
- Notice what’s coming up for us, and to attend to our emotions. This is much, much more important than people realize — most of our problems come from an inability to regulate our emotions or even recognize that they’re there.
- Make decisions from a place of choosing from the heart. If we have a decision to make, instead of overthinking it, w…
Source https://zenhabits.net/slow-retreat/
Our days are a busy rush, often from the moment we wake up. Even in our moments of rest, we are often on our phones or using technology to distract ourselves. The result is a life of stress, overwhelm, and habitual patterns.
What would it be like to slow down? To find stillness in your day, moments of rest and quietude?
The possibility of slowing down goes much deeper than just having a bit less busyness in your day …
Slowing down, if we go deeper, allows us to:
- Notice what’s coming up for us, and to attend to our emotions. This is much, much more important than people realize — most of our problems come from an inability to regulate our emotions or even recognize that they’re there.
- Make decisions from a place of choosing from the heart. If we have a decision to make, instead of overthinking it, w…
Source https://www.ageinplacetech.com/blog/predictions-report-tech-user-experience-needs-upgrade
The decline of our tech experience was slow – it was barely noticeable for a while. Then device proliferation in homes – and the corresponding frustration became too obvious to miss. An AARP report notes, “No one prefers badly designed, over-complicated products.” Yet that’s what we get. Despite preferences, surveys show that today’s user experience for older adults is more problematic than ever. All are confronted with buggy software and <a href="https://www.forbes.com/sites/mollybohannon/2023/11/07/apple-will-focus-on-fixing-phone-and-computer-glitches-before-new-updates-report-says/?sh=7afbaf241878" targ…
Source https://www.ageinplacetech.com/blog/predictions-report-tech-user-experience-needs-upgrade
The decline of our tech experience was slow – it was barely noticeable for a while. Then device proliferation in homes – and the corresponding frustration became too obvious to miss. An AARP report notes, “No one prefers badly designed, over-complicated products.” Yet that’s what we get. Despite preferences, surveys show that today’s user experience for older adults is more problematic than ever. All are confronted with buggy software and <a href="https://www.forbes.com/sites/mollybohannon/2023/11/07/apple-will-focus-on-fixing-phone-and-computer-glitches-before-new-updates-report-says/?sh=7afbaf241878" targ…
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