Source https://www.fightaging.org/archives/2021/01/thoughts-on-the-road-to-greater-human-longevity/
I recently noticed this scientific commentary, published in a journal not specifically focused on aging. The author is far from the only person to have noticed that priorities in medical research and development do not seem to match up with the major causes of death all that well. It can’t hurt to keep on pointing out that research into the most harmful biological processes in the world, meaning the mechanisms that cause aging, is very poorly funded and investigated in comparison to the vast and ongoing toll of death that results. Until aging is defeated, more funding for research into rejuvenation therapies will continue to be the most cost-effective way to improve the human condition.
Longevity me…
Source https://www.fightaging.org/archives/2021/01/thoughts-on-the-road-to-greater-human-longevity/
I recently noticed this scientific commentary, published in a journal not specifically focused on aging. The author is far from the only person to have noticed that priorities in medical research and development do not seem to match up with the major causes of death all that well. It can’t hurt to keep on pointing out that research into the most harmful biological processes in the world, meaning the mechanisms that cause aging, is very poorly funded and investigated in comparison to the vast and ongoing toll of death that results. Until aging is defeated, more funding for research into rejuvenation therapies will continue to be the most cost-effective way to improve the human condition.
Longevity me…
Source http://feedproxy.google.com/~r/tinybuddha/~3/9zKij48ezoc/
“Confidence isn’t ‘they will like me.’ Confidence is ‘I’ll be fine if they don’t’.” ~Christina Grimmie
No one likes rejection. Some people have gotten comfortable with it, perhaps have even reframed it as something positive, but most of us prefer that other people approve of us and our choices.
It gives us a sense of security to know the people around us like us, understand us, support our decisions, and generally think we’re good people who deserve love, respect, and kindness. It makes us feel confident in our place within a social structure and assured that we won’t be alone when we need people the most.
But the need for approval—from all people, at all times—can be extremely painful and limiting. And it’s a fool’s errand to s…
Source http://feedproxy.google.com/~r/tinybuddha/~3/9zKij48ezoc/
“Confidence isn’t ‘they will like me.’ Confidence is ‘I’ll be fine if they don’t’.” ~Christina Grimmie
No one likes rejection. Some people have gotten comfortable with it, perhaps have even reframed it as something positive, but most of us prefer that other people approve of us and our choices.
It gives us a sense of security to know the people around us like us, understand us, support our decisions, and generally think we’re good people who deserve love, respect, and kindness. It makes us feel confident in our place within a social structure and assured that we won’t be alone when we need people the most.
But the need for approval—from all people, at all times—can be extremely painful and limiting. And it’s a fool’s errand to s…
Source http://feedproxy.google.com/~r/tinybuddha/~3/YmkKSAxSIFo/
“Remember that not getting what you want Is sometimes a wonderful stroke of luck.” ~Dalai Lama
Let me tell you a story. I first read it in a book on Taoism, but I’ve seen it in at least a dozen other places since then, each with its own variation. Here’s the gist:
There’s this farmer. His favorite horse runs away. Everyone tells him that this is a terrible turn of events and that they are sorry for him. He says, “We’ll see.”
The horse comes back a few days later, and it brings an entire herd of wild horses with it. Everyone tells him that this is a wonderful turn of events and that they’re happy for him. He says, “We’ll see.”
The farmer’s son is trying to break one of the new horses, it throws him, and he breaks hi…
Source http://feedproxy.google.com/~r/tinybuddha/~3/YmkKSAxSIFo/
“Remember that not getting what you want Is sometimes a wonderful stroke of luck.” ~Dalai Lama
Let me tell you a story. I first read it in a book on Taoism, but I’ve seen it in at least a dozen other places since then, each with its own variation. Here’s the gist:
There’s this farmer. His favorite horse runs away. Everyone tells him that this is a terrible turn of events and that they are sorry for him. He says, “We’ll see.”
The horse comes back a few days later, and it brings an entire herd of wild horses with it. Everyone tells him that this is a wonderful turn of events and that they’re happy for him. He says, “We’ll see.”
The farmer’s son is trying to break one of the new horses, it throws him, and he breaks hi…
Source https://www.fightaging.org/archives/2021/01/targeting-neuroinflammation-in-alzheimers-disease/
As noted by the authors of today’s open access review paper, Alzheimer’s disease is just as strongly characterized by chronic inflammation in brain tissue as it is by the presence of aggregates of amyloid-β and phosphorylated tau. More modern views of Alzheimer’s disease etiology place more emphasis on chronic inflammation as a cause of pathology, either wrapping it into the amyloid cascade hypothesis, or replacing amyloid-β with inflammatory processes in the progression of the foundational, earlier stage of the condition.
</p…
Source https://www.fightaging.org/archives/2021/01/targeting-neuroinflammation-in-alzheimers-disease/
As noted by the authors of today’s open access review paper, Alzheimer’s disease is just as strongly characterized by chronic inflammation in brain tissue as it is by the presence of aggregates of amyloid-β and phosphorylated tau. More modern views of Alzheimer’s disease etiology place more emphasis on chronic inflammation as a cause of pathology, either wrapping it into the amyloid cascade hypothesis, or replacing amyloid-β with inflammatory processes in the progression of the foundational, earlier stage of the condition.
</p…
Source https://www.fightaging.org/archives/2021/01/nanomaterials-for-the-clearance-of-senescent-cells/
Senescent cell accumulation is a contributing cause of aging, and targeted destruction of senescent cells with senolytic therapies produces meaningful rejuvenation and reversal of age-related disease in animal models. First generation senolytics are largely repurposed small molecules. Second generation senolytics will include a r…
Source https://www.fightaging.org/archives/2021/01/nanomaterials-for-the-clearance-of-senescent-cells/
Senescent cell accumulation is a contributing cause of aging, and targeted destruction of senescent cells with senolytic therapies produces meaningful rejuvenation and reversal of age-related disease in animal models. First generation senolytics are largely repurposed small molecules. Second generation senolytics will include a r…
Source https://seniorplanet.org/get-on-top-of-your-tech-in-2021/
Resolve to Get on top of your tech in 2021 with these quick fixes.
The post Get on Top of Your Tech in 2021 appeared first on Senior Planet.
…
Source https://seniorplanet.org/get-on-top-of-your-tech-in-2021/
Resolve to Get on top of your tech in 2021 with these quick fixes.
The post Get on Top of Your Tech in 2021 appeared first on Senior Planet.
…
Source https://www.fightaging.org/archives/2021/01/an-example-of-high-dose-fisetin-exhibiting-senolytic-effects-in-mice/
Fisetin is perhaps the most intriguing of the first generation senolytic compounds, those capable of selectively destroying senescent cells in old tissues and thus producing rejuvenation to a meaningful degree. Senolytics have been demonstrated in animal studies to reverse many age-related conditions to a greater degree than any other approaches. Why is fisetin intriguing? Because in mice, it appears to be about as effective as the dasatinib and quercetin combination, yet it is a widely …
Source https://www.fightaging.org/archives/2021/01/an-example-of-high-dose-fisetin-exhibiting-senolytic-effects-in-mice/
Fisetin is perhaps the most intriguing of the first generation senolytic compounds, those capable of selectively destroying senescent cells in old tissues and thus producing rejuvenation to a meaningful degree. Senolytics have been demonstrated in animal studies to reverse many age-related conditions to a greater degree than any other approaches. Why is fisetin intriguing? Because in mice, it appears to be about as effective as the dasatinib and quercetin combination, yet it is a widely …
Source https://www.fightaging.org/archives/2021/01/fight-aging-newsletter-january-11th-2021/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
- An Update on Progress at Tissue Engineering Company Lygenesis
- Exercise as a Mild Senotherapeutic</…
Source https://www.fightaging.org/archives/2021/01/fight-aging-newsletter-january-11th-2021/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
- An Update on Progress at Tissue Engineering Company Lygenesis
- Exercise as a Mild Senotherapeutic</…