Source https://www.fightaging.org/archives/2021/12/microglia-as-mediators-of-the-link-between-psychological-stress-and-cognitive-aging/
Psychological stress appears to modestly accelerate some measures of aging, though most of the evidence for this correlation comes from animal studies. Evidence points to chronic inflammation, and the immune system in general, as an important factor in this correlation. Separately, chronic inflammation in brain tissue is known to be important in neurodegenerative conditions, and the behavior of innate immune cells known as <a href="https://en.wikip…
Source https://www.fightaging.org/archives/2021/12/microglia-as-mediators-of-the-link-between-psychological-stress-and-cognitive-aging/
Psychological stress appears to modestly accelerate some measures of aging, though most of the evidence for this correlation comes from animal studies. Evidence points to chronic inflammation, and the immune system in general, as an important factor in this correlation. Separately, chronic inflammation in brain tissue is known to be important in neurodegenerative conditions, and the behavior of innate immune cells known as <a href="https://en.wikip…
Source https://www.fightaging.org/archives/2021/11/macrophages-essential-to-limb-regeneration-in-the-axolotl-emerge-from-the-liver/
Regeneration from injury is an intricate dance between stem cells, somatic cells, senescent cells, and immune cells. In particular, research into the biochemistry of species such the axolotl that can regenerate limbs and organs has identified the innate immune cells known as macrophages as essential to the process. Specific differences in macrophage behavior between more regenerative species such as the axolotl and less regenerative species such as our own are still under exploration. Here, researchers uncover a greater level of complexity in axolotl regeneration, in that only some mac…
Source https://www.fightaging.org/archives/2021/11/macrophages-essential-to-limb-regeneration-in-the-axolotl-emerge-from-the-liver/
Regeneration from injury is an intricate dance between stem cells, somatic cells, senescent cells, and immune cells. In particular, research into the biochemistry of species such the axolotl that can regenerate limbs and organs has identified the innate immune cells known as macrophages as essential to the process. Specific differences in macrophage behavior between more regenerative species such as the axolotl and less regenerative species such as our own are still under exploration. Here, researchers uncover a greater level of complexity in axolotl regeneration, in that only some mac…
Source https://www.fightaging.org/archives/2021/11/heart-rate-variability-aging-and-cardiovascular-fitness/
Heart rate variability is an increasingly popular measure of cardiovascular health. Heart rate variability is known to decline with age, but to what degree is this a reflection of processes of cardiovascular aging versus the loss of physical fitness that is a feature of old age in our present, overly sedentary societies? This remains an open question, and an important one, given the range of evidence for exercise programs, and thus increased physical fitness, to be as effective as many medical interventions when it comes to improving cardiovascular health and reducing mortality in later life. Yes, aging causes an inevitable decline in physical condition, but living a sedentary lifestyle certainly speeds up that process.
…
Source https://www.fightaging.org/archives/2021/11/heart-rate-variability-aging-and-cardiovascular-fitness/
Heart rate variability is an increasingly popular measure of cardiovascular health. Heart rate variability is known to decline with age, but to what degree is this a reflection of processes of cardiovascular aging versus the loss of physical fitness that is a feature of old age in our present, overly sedentary societies? This remains an open question, and an important one, given the range of evidence for exercise programs, and thus increased physical fitness, to be as effective as many medical interventions when it comes to improving cardiovascular health and reducing mortality in later life. Yes, aging causes an inevitable decline in physical condition, but living a sedentary lifestyle certainly speeds up that process.
…
Source https://www.fightaging.org/archives/2021/11/results-from-a-trial-of-the-senolytic-fisetin-in-a-single-individual-with-autoimmunity/
Today’s materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has…
Source https://www.fightaging.org/archives/2021/11/results-from-a-trial-of-the-senolytic-fisetin-in-a-single-individual-with-autoimmunity/
Today’s materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has…
Source https://tinybuddha.com/blog/how-i-recognized-my-fear-of-failure-and-how-im-mindfully-overcoming-it/
“The only way to ease our fear and be truly happy is to acknowledge our fear and look deeply at its source. Instead of trying to escape from our fear, we can invite it up to our awareness and look at it clearly and deeply.” ~Thich Nhat Hanh
My daughter began taking tumbling classes a week before her eighth birthday. She had been dancing since the age of three, and those classes included instructions for cartwheels and roundoffs. The harder stuff, like the back walkover, required tumbling or gymnastics classes, and she wanted the chance to be able to show off those moves during the annual dance recital.
My wife wasn’t interested in watching our daughter repeatedly and blindly dive backward in a bendy arch, each time hoping her hands met the ground firmly enough to slow …
Source https://tinybuddha.com/blog/how-i-recognized-my-fear-of-failure-and-how-im-mindfully-overcoming-it/
“The only way to ease our fear and be truly happy is to acknowledge our fear and look deeply at its source. Instead of trying to escape from our fear, we can invite it up to our awareness and look at it clearly and deeply.” ~Thich Nhat Hanh
My daughter began taking tumbling classes a week before her eighth birthday. She had been dancing since the age of three, and those classes included instructions for cartwheels and roundoffs. The harder stuff, like the back walkover, required tumbling or gymnastics classes, and she wanted the chance to be able to show off those moves during the annual dance recital.
My wife wasn’t interested in watching our daughter repeatedly and blindly dive backward in a bendy arch, each time hoping her hands met the ground firmly enough to slow …
Source https://www.fightaging.org/archives/2021/11/the-lack-of-funding-for-chronic-kidney-disease-research-is-not-an-outlier/
In this commentary, scientists note the paucity of funding for chronic kidney disease research, given the widespread suffering and death caused by this presently incurable condition. This and many other areas of medicine are seen as solved problems by the powers that be simply because there is some form of treatment, even palliative treatment, in widespread use. That the treatment does little and many people die doesn’t appear to motivate those who could fund progress. There is no sense of urgency and little sense of need. We might make the same comments in the case of atherosclerosis, a condition many consider to be adequately treated and under control, due to the existence of statins and similar drugs that lower LDL cholesterol in the bl…
Source https://www.fightaging.org/archives/2021/11/the-lack-of-funding-for-chronic-kidney-disease-research-is-not-an-outlier/
In this commentary, scientists note the paucity of funding for chronic kidney disease research, given the widespread suffering and death caused by this presently incurable condition. This and many other areas of medicine are seen as solved problems by the powers that be simply because there is some form of treatment, even palliative treatment, in widespread use. That the treatment does little and many people die doesn’t appear to motivate those who could fund progress. There is no sense of urgency and little sense of need. We might make the same comments in the case of atherosclerosis, a condition many consider to be adequately treated and under control, due to the existence of statins and similar drugs that lower LDL cholesterol in the bl…
Source https://www.fightaging.org/archives/2021/11/tongue-exercise-does-not-help-with-the-age-related-decline-of-tongue-muscle-function-in-rats/
Exercise in the form of strength training creates such broad changes in metabolism and produces such diverse benefits to health that it is interesting to see a specific example in which it doesn’t help at all. That is possibly a path to better understanding which of the results of exercise are important, versus which are not, when it comes to functional improvement of specific tissues in later life. Many of the benefit of exercise are likely secondary effects produced by changes in skeletal muscle metabolism and myokine signaling on other parts of the body. Those effects will be largely absent in a study such as this, where only one small set of muscles are tr…
Source https://www.fightaging.org/archives/2021/11/tongue-exercise-does-not-help-with-the-age-related-decline-of-tongue-muscle-function-in-rats/
Exercise in the form of strength training creates such broad changes in metabolism and produces such diverse benefits to health that it is interesting to see a specific example in which it doesn’t help at all. That is possibly a path to better understanding which of the results of exercise are important, versus which are not, when it comes to functional improvement of specific tissues in later life. Many of the benefit of exercise are likely secondary effects produced by changes in skeletal muscle metabolism and myokine signaling on other parts of the body. Those effects will be largely absent in a study such as this, where only one small set of muscles are tr…
Source https://tinybuddha.com/blog/want-to-help-someone-through-depression-here-are-a-few-things-to-try/
“There were two classes of charitable people: one, the people who did a little and made a great deal of noise; the other, the people who did a great deal and made no noise at all.” ~Charles Dickens
“It’ll be okay, just…”
If I could have taken that expression and thrown it at each person who said it to me when I was struggling with depression, it would have felt much better than hearing it each time.
Here are a few ways people ended that sentence:
“Try not to think about it.”
“Cheer up.”
“Get some exercise.“
“See someone about it.”
All well-intentioned, true, and completely unhelpful.
I didn’t need to hear advice, or pointers or solutions. I just needed them to…
Source https://tinybuddha.com/blog/want-to-help-someone-through-depression-here-are-a-few-things-to-try/
“There were two classes of charitable people: one, the people who did a little and made a great deal of noise; the other, the people who did a great deal and made no noise at all.” ~Charles Dickens
“It’ll be okay, just…”
If I could have taken that expression and thrown it at each person who said it to me when I was struggling with depression, it would have felt much better than hearing it each time.
Here are a few ways people ended that sentence:
“Try not to think about it.”
“Cheer up.”
“Get some exercise.“
“See someone about it.”
All well-intentioned, true, and completely unhelpful.
I didn’t need to hear advice, or pointers or solutions. I just needed them to…
Source https://www.fightaging.org/archives/2021/11/senolytic-treatment-minimizes-the-contribution-of-excess-fat-tissue-to-insulin-resistance-in-mice/
Senescent cells accumulate with age throughout the body, and contribute directly to the onset and progression of a wide range of age-related conditions. While never present in large numbers in comparison to normal somatic cells, senescent cells are metabolically active, secreting signals that provoke chronic inflammation, altered cell behavior, and numerous forms of tissue dysfunction. <a href="https://www.fightaging.org/archives/2017/09/senolytic-therapies-to-clear-senescent-cells-will-transform-the-field-of-medicine-for-age…
Source https://www.fightaging.org/archives/2021/11/senolytic-treatment-minimizes-the-contribution-of-excess-fat-tissue-to-insulin-resistance-in-mice/
Senescent cells accumulate with age throughout the body, and contribute directly to the onset and progression of a wide range of age-related conditions. While never present in large numbers in comparison to normal somatic cells, senescent cells are metabolically active, secreting signals that provoke chronic inflammation, altered cell behavior, and numerous forms of tissue dysfunction. <a href="https://www.fightaging.org/archives/2017/09/senolytic-therapies-to-clear-senescent-cells-will-transform-the-field-of-medicine-for-age…