Researchers here report on an interesting discovery relating to the way in which aquaporin-4 functions in clearance of molecular waste from the brain. An uncommon isoform of aquaporin-4 has a role in clearing excess amyloid-β, and possibly many other forms of molecular waste. Given that a failure of clearance of molecular waste from the brain is apparently involved in many neurodegenerative conditions, approaches that enhance clearance are promising. Increased amounts of this more effective isoform can be achieved via a variety of strategies in mice, and in mice engineered to generate excess amyloid-β, this results in a reduction of amyloid-β in the brain. This is quite interesting, but further work is required to determine a useful way to impleme…
Researchers here report on an interesting discovery relating to the way in which aquaporin-4 functions in clearance of molecular waste from the brain. An uncommon isoform of aquaporin-4 has a role in clearing excess amyloid-β, and possibly many other forms of molecular waste. Given that a failure of clearance of molecular waste from the brain is apparently involved in many neurodegenerative conditions, approaches that enhance clearance are promising. Increased amounts of this more effective isoform can be achieved via a variety of strategies in mice, and in mice engineered to generate excess amyloid-β, this results in a reduction of amyloid-β in the brain. This is quite interesting, but further work is required to determine a useful way to impleme…
“Care about what other people think and you will always be their prisoner.” ~Lao Tzu
We carefully pick out what we wear to the gym to make sure we look good in the eyes of the other gym goers.
We beat ourselves up after meetings running through everything we said (or didn’t say), worried that coworkers will think we aren’t smart or talented enough.
We post only the best picture out of the twenty-seven selfies we took and add a flattering filter to get the most likes to prove to ourselves that we are pretty and likable.
We live in other people’s heads.
And all it does is make us judge ourselves more harshly. It makes us uncomfortable in our own bodies. It makes us feel apologetic for being ourselves. It makes us live accordi…
“Care about what other people think and you will always be their prisoner.” ~Lao Tzu
We carefully pick out what we wear to the gym to make sure we look good in the eyes of the other gym goers.
We beat ourselves up after meetings running through everything we said (or didn’t say), worried that coworkers will think we aren’t smart or talented enough.
We post only the best picture out of the twenty-seven selfies we took and add a flattering filter to get the most likes to prove to ourselves that we are pretty and likable.
We live in other people’s heads.
And all it does is make us judge ourselves more harshly. It makes us uncomfortable in our own bodies. It makes us feel apologetic for being ourselves. It makes us live accordi…
Diluting blood plasma in old individuals reduces circulating levels of harmful signals, such as pro-inflammatory proteins and debris, for long enough to allow improvement in tissue function. Significant dilution requires the introduction of new albumin, and there is presently some question over how much of the benefits result from the dilution of circulating factors versus delivery of albumin which is typically sourced from blood donations from (on average) younger individuals, and is thus less damaged. Researchers here report on the effects of repeated plasma dilution treatments in three human patients, showing an improvement in circulating protein levels known to change with age, some inflammati…
Diluting blood plasma in old individuals reduces circulating levels of harmful signals, such as pro-inflammatory proteins and debris, for long enough to allow improvement in tissue function. Significant dilution requires the introduction of new albumin, and there is presently some question over how much of the benefits result from the dilution of circulating factors versus delivery of albumin which is typically sourced from blood donations from (on average) younger individuals, and is thus less damaged. Researchers here report on the effects of repeated plasma dilution treatments in three human patients, showing an improvement in circulating protein levels known to change with age, some inflammati…
South American cuisine is full of colorful, flavorful options — including ceviche, a traditional dish of raw seafood marinated in citrus juice. But if the words “raw seafood” strike fear into your heart, you might (understandably) be skeptical of ceviche.
Need a bit more info before you dive right into this Peruvian classic? Let’s talk ceviche deets.
The origins of ceviche
Food historians believe ceviche (also known as seviche or cebiche) originated among the Incas, who seasoned their fish wi…
South American cuisine is full of colorful, flavorful options — including ceviche, a traditional dish of raw seafood marinated in citrus juice. But if the words “raw seafood” strike fear into your heart, you might (understandably) be skeptical of ceviche.
Need a bit more info before you dive right into this Peruvian classic? Let’s talk ceviche deets.
The origins of ceviche
Food historians believe ceviche (also known as seviche or cebiche) originated among the Incas, who seasoned their fish wi…
I know it’s not easy to feel cut off from your child when you still feel love and maybe even remorse. I know you might feel confused about why your adult child is so upset, and you might even feel angry and wrongly accused.
Perhaps there’s some truth to that. I don’t know why your child cut ties with you, but I can share a little of my own experience and then offer some tips that might help, regardless of your unique situation.
So why did your son or daughter cut you out of their life?
I can’t speak to the specifics of your situation, but I can offer you some insights from my own experience and I can talk about common themes expressed by my community of estranged adults.
I know it’s not easy to feel cut off from your child when you still feel love and maybe even remorse. I know you might feel confused about why your adult child is so upset, and you might even feel angry and wrongly accused.
Perhaps there’s some truth to that. I don’t know why your child cut ties with you, but I can share a little of my own experience and then offer some tips that might help, regardless of your unique situation.
So why did your son or daughter cut you out of their life?
I can’t speak to the specifics of your situation, but I can offer you some insights from my own experience and I can talk about common themes expressed by my community of estranged adults.
The varieties of B cell in the immune system participate in the immune response to pathogens by creating antibodies to match specific antigens, and spreading the information represented by that antibody to portions of the adaptive immune system capable of attacking threats. This is a very crude, high level summary of an enormously complex system. The fine details of how subsets of the B cell population generate suitable antibodies, and then communicate with one another and the rest of the immune system, are complicated indeed, involving many different subsets of cell, different paths of activation, and different mechanisms.
The varieties of B cell in the immune system participate in the immune response to pathogens by creating antibodies to match specific antigens, and spreading the information represented by that antibody to portions of the adaptive immune system capable of attacking threats. This is a very crude, high level summary of an enormously complex system. The fine details of how subsets of the B cell population generate suitable antibodies, and then communicate with one another and the rest of the immune system, are complicated indeed, involving many different subsets of cell, different paths of activation, and different mechanisms.
With the 79th anniversary of the Social Security Act, retirees (and most workers) worry about its solvency; will it run out of money to pay benefits.? What can be done about it?
With the 79th anniversary of the Social Security Act, retirees (and most workers) worry about its solvency; will it run out of money to pay benefits.? What can be done about it?
This post is an update for an earlier report on a self-experiment with flagellin immunization, tested as an approach to adjust the balance of microbial populations in the aging gut microbiome in a favorable, more youthful direction. Commentary and data from the earlier report are repeated, with the addition of a new assessment of the gut microbiome taken two years after the end of the experiment. In summary, changes from this short and simple intervention were largely favorable, and largely sustained over this period of time.
Flagellin is the protein that makes up bacterial flagellae, and it is hypothesized that there is a sizable overlap between populations of gut m…
This post is an update for an earlier report on a self-experiment with flagellin immunization, tested as an approach to adjust the balance of microbial populations in the aging gut microbiome in a favorable, more youthful direction. Commentary and data from the earlier report are repeated, with the addition of a new assessment of the gut microbiome taken two years after the end of the experiment. In summary, changes from this short and simple intervention were largely favorable, and largely sustained over this period of time.
Flagellin is the protein that makes up bacterial flagellae, and it is hypothesized that there is a sizable overlap between populations of gut m…
Tattoo bubbling is when healing tattooed skin becomes saturated with moisture. This can increase your risk of infection and tattoo damage.
A lot can happen in the time it takes a tattoo to heal. One potential problem is tattoo bubbling, which is when the healing skin absorbs too much moisture and starts to appear raised.
Tattoo bubbling can lead to wet scabs that fall off easily and damage your tattoo. Plus, it also increases your risk of infection.
Here’s how you can prevent tattoo bubbling after you get inked and what to do if it’s already happened.
What causes tattoo bubbling?
During the <a rel="noreferrer noopener" href="/live/uv-tatt…
Tattoo bubbling is when healing tattooed skin becomes saturated with moisture. This can increase your risk of infection and tattoo damage.
A lot can happen in the time it takes a tattoo to heal. One potential problem is tattoo bubbling, which is when the healing skin absorbs too much moisture and starts to appear raised.
Tattoo bubbling can lead to wet scabs that fall off easily and damage your tattoo. Plus, it also increases your risk of infection.
Here’s how you can prevent tattoo bubbling after you get inked and what to do if it’s already happened.
What causes tattoo bubbling?
During the <a rel="noreferrer noopener" href="/live/uv-tatt…
