Source https://tinybuddha.com/blog/shifting-out-of-survival-mode-healing-happens-one-choice-at-a-time/
“When we are no longer able to change a situation, we are challenged to change ourselves.” ~Viktor Frankl
It started as a faint hum—a sense of unease that crept in during the isolation of the pandemic. I was a licensed therapist working from home, meeting with clients through a screen. Together, we were navigating a shared uncertainty, trying to cope as the world shifted beneath us.
I could feel the weight of their anxiety as they talked about their spiraling thoughts and struggles to feel grounded. What I didn’t realize then was how much of their turmoil was a reflection of my own.
During those months, I gave my clients all the tools I knew. We talked about …
Source https://tinybuddha.com/blog/shifting-out-of-survival-mode-healing-happens-one-choice-at-a-time/
“When we are no longer able to change a situation, we are challenged to change ourselves.” ~Viktor Frankl
It started as a faint hum—a sense of unease that crept in during the isolation of the pandemic. I was a licensed therapist working from home, meeting with clients through a screen. Together, we were navigating a shared uncertainty, trying to cope as the world shifted beneath us.
I could feel the weight of their anxiety as they talked about their spiraling thoughts and struggles to feel grounded. What I didn’t realize then was how much of their turmoil was a reflection of my own.
During those months, I gave my clients all the tools I knew. We talked about …
Source https://www.fightaging.org/archives/2025/11/the-longevity-associated-variant-of-bpifb4-can-be-provided-orally-to-produce-benefits-in-mice/
Proteins are largely quite delicate structures dependent on being manufactured and correctly folded and localized inside a cell. Thus no-one tries to make recombinant proteins or deliver them as a therapy for the vast majority of proteins. The exceptions are those proteins robust enough to be secreted by a cell and circulate in blood and other fluids in the body. In that case one can develop means of manufacture and build a recombinant protein that can be injected as a basis for therapy, assuming that more of that protein is a desirable goal. So far as I am aware it is unusual to find a protein that can survive oral administration and the harsh environment of the gastrointestinal tract, and then enter circulation to produce the same beneficial effects that the natively manufactured protein is c…
Source https://www.fightaging.org/archives/2025/11/the-longevity-associated-variant-of-bpifb4-can-be-provided-orally-to-produce-benefits-in-mice/
Proteins are largely quite delicate structures dependent on being manufactured and correctly folded and localized inside a cell. Thus no-one tries to make recombinant proteins or deliver them as a therapy for the vast majority of proteins. The exceptions are those proteins robust enough to be secreted by a cell and circulate in blood and other fluids in the body. In that case one can develop means of manufacture and build a recombinant protein that can be injected as a basis for therapy, assuming that more of that protein is a desirable goal. So far as I am aware it is unusual to find a protein that can survive oral administration and the harsh environment of the gastrointestinal tract, and then enter circulation to produce the same beneficial effects that the natively manufactured protein is c…
Source https://www.theminimalists.com/p512/
The Minimalists speak with Guy Finley about letting go of precious memories, why letting go is so freaking scary, the wisdom of letting go, ten truths to follow if you want to let go, and much more.
Listen to the Episode
Apple · Spotify · Patreon
Discussed in This Episode
- How can I let go of things that are imbued with my precious memories?
- Why is letting go so scary?
- How does our desire to control prevent us from le…
Source https://www.theminimalists.com/p512/
The Minimalists speak with Guy Finley about letting go of precious memories, why letting go is so freaking scary, the wisdom of letting go, ten truths to follow if you want to let go, and much more.
Listen to the Episode
Apple · Spotify · Patreon
Discussed in This Episode
- How can I let go of things that are imbued with my precious memories?
- Why is letting go so scary?
- How does our desire to control prevent us from le…
Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-november-3rd-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-november-3rd-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/10/misfolded-%CE%B1-synuclein-breaks-down-atp-harming-cell-function-in-the-brain/
Synucleinopathies such as Parkinson’s disease are caused by the spread of misfolded α-synuclein through the brain. α-synuclein is one of a small number of proteins that, when misfolded, can encourage other molecules of the same protein to misfold in the same way, aggregating to form toxic solid deposits and a halo of disrupted biochemistry. Misfolded α-synuclein is particularly pernicious as it can pass from cell to cell, spreading pathology as it goes. Here, researchers explore one of the ways in which misfolded α-synuclein harms cells, by interfering in the supply of the energy store molecule adenosine triphosphate (ATP) that is produced by <a href="https://en.wikip…
Source https://www.fightaging.org/archives/2025/10/misfolded-%CE%B1-synuclein-breaks-down-atp-harming-cell-function-in-the-brain/
Synucleinopathies such as Parkinson’s disease are caused by the spread of misfolded α-synuclein through the brain. α-synuclein is one of a small number of proteins that, when misfolded, can encourage other molecules of the same protein to misfold in the same way, aggregating to form toxic solid deposits and a halo of disrupted biochemistry. Misfolded α-synuclein is particularly pernicious as it can pass from cell to cell, spreading pathology as it goes. Here, researchers explore one of the ways in which misfolded α-synuclein harms cells, by interfering in the supply of the energy store molecule adenosine triphosphate (ATP) that is produced by <a href="https://en.wikip…
Source https://www.fightaging.org/archives/2025/10/degeneration-of-the-tectorial-membrane-in-age-related-hearing-loss/
Researchers here propose a novel form of damage and dysfunction contributing to the development of age-related hearing loss. Much of the focus of past years of research has been placed upon loss of connectivity between sensory hair cells of the inner ear and the brain, or outright loss of hair cells themselves. But there are other components of the overall problem of loss of function, as noted here, and the question of what to do about it doesn’t always have as straightforward a path towards practical therapies as exists for loss of cells.
Age-related hearing loss is common among older adults and can result from several problems in the inner ear. The disorder is usually classified into three types: (a) Neural: due to damage to auditory nerve fibres, (b) Sensory: caused by the loss of the s…
Source https://www.fightaging.org/archives/2025/10/degeneration-of-the-tectorial-membrane-in-age-related-hearing-loss/
Researchers here propose a novel form of damage and dysfunction contributing to the development of age-related hearing loss. Much of the focus of past years of research has been placed upon loss of connectivity between sensory hair cells of the inner ear and the brain, or outright loss of hair cells themselves. But there are other components of the overall problem of loss of function, as noted here, and the question of what to do about it doesn’t always have as straightforward a path towards practical therapies as exists for loss of cells.
Age-related hearing loss is common among older adults and can result from several problems in the inner ear. The disorder is usually classified into three types: (a) Neural: due to damage to auditory nerve fibres, (b) Sensory: caused by the loss of the s…
Source https://www.theminimalists.com/no/
T.K. Coleman discusses five strategies for saying no without guilt.
How do you say no? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Just Say No appeared first on The Minimalists.
…
Source https://www.theminimalists.com/no/
T.K. Coleman discusses five strategies for saying no without guilt.
How do you say no? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Just Say No appeared first on The Minimalists.
…
Source https://www.fightaging.org/archives/2025/10/the-role-of-mitochondrial-dysfunction-in-sarcopenia/
The hundreds of mitochondria present in every cell work to produce the chemical energy store molecule adenosine triphosphate (ATP), necessary for cell function. With age, some combination of damage to mitochondrial DNA and changes in the epigenetic control of gene expression act to degrade mitochondrial ATP production and otherwise ensure that mitochondria function progressively less effectively. This stresses cells and negatively affects tissue function. Here, researchers review what is known of mitochondrial loss of function in muscle tissue, leading to the characteristic loss of muscle mass and strength that occurs with aging and leads to <a href="https://en.wikipedia.org/wiki/Sar…
Source https://www.fightaging.org/archives/2025/10/the-role-of-mitochondrial-dysfunction-in-sarcopenia/
The hundreds of mitochondria present in every cell work to produce the chemical energy store molecule adenosine triphosphate (ATP), necessary for cell function. With age, some combination of damage to mitochondrial DNA and changes in the epigenetic control of gene expression act to degrade mitochondrial ATP production and otherwise ensure that mitochondria function progressively less effectively. This stresses cells and negatively affects tissue function. Here, researchers review what is known of mitochondrial loss of function in muscle tissue, leading to the characteristic loss of muscle mass and strength that occurs with aging and leads to <a href="https://en.wikipedia.org/wiki/Sar…
Source https://www.fightaging.org/archives/2025/10/incompletely-understood-changes-in-immunoglobulins-take-place-with-age/
Immunoglobulin proteins are also known as antibodies, and can circulate freely or be bound to cell surfaces. They serve to tag specific structures for recognition and attack by the immune system, so a very broad range of variants on the basic structure are manufactured by plasma cells derived from B cells in response to the presence of immune-provoking antigens. These immunoglobulins then go on to shape the behavior of the immune system as a whole. Here, researchers take a tour of what is known of age-related changes in immunoglobulins, an area of study in which all too little is completely mapped or understood. To understand what is observed, one would hav…
Source https://www.fightaging.org/archives/2025/10/incompletely-understood-changes-in-immunoglobulins-take-place-with-age/
Immunoglobulin proteins are also known as antibodies, and can circulate freely or be bound to cell surfaces. They serve to tag specific structures for recognition and attack by the immune system, so a very broad range of variants on the basic structure are manufactured by plasma cells derived from B cells in response to the presence of immune-provoking antigens. These immunoglobulins then go on to shape the behavior of the immune system as a whole. Here, researchers take a tour of what is known of age-related changes in immunoglobulins, an area of study in which all too little is completely mapped or understood. To understand what is observed, one would hav…