Chronic inflammation is a serious issue in later life, contributing to the onset and progression of all of the common fatal age-related conditions. This unresolved inflammation arises for many reasons, such as the pro-inflammatory signaling produced by senescent cells, the reaction of immune cells to persistent pathogens, rising levels of molecular damage and stressed cells as a result of the aging tissue environment, and so forth. The challenge lies in identifying which of these mechanisms are the most influential. The only practic…
Chronic inflammation is a serious issue in later life, contributing to the onset and progression of all of the common fatal age-related conditions. This unresolved inflammation arises for many reasons, such as the pro-inflammatory signaling produced by senescent cells, the reaction of immune cells to persistent pathogens, rising levels of molecular damage and stressed cells as a result of the aging tissue environment, and so forth. The challenge lies in identifying which of these mechanisms are the most influential. The only practic…
In this episode of The Minimalists Podcast, The Minimalists discuss what to do with family heirlooms and “generational junk,” and they answer the following ques…
In this episode of The Minimalists Podcast, The Minimalists discuss what to do with family heirlooms and “generational junk,” and they answer the following ques…
It is intriguing to see that calorie restriction and mTOR inhibition are additive when it comes to slowing the age-related loss of muscle mass and strength, the path to sarcopenia. Both interventions are thought to influence long-term health largely through upregulation of autophagy, but calorie restriction produces very broad, sweeping changes in metabolism. The downstream changes due to mTOR inhibition only touch on a fraction of those. Thus this result may in time lead to a better understanding of which mechanisms are important in the way in which the operation of metabolism determines the pace of aging. Still, we know the scope of the benefits produced by calorie restri…
It is intriguing to see that calorie restriction and mTOR inhibition are additive when it comes to slowing the age-related loss of muscle mass and strength, the path to sarcopenia. Both interventions are thought to influence long-term health largely through upregulation of autophagy, but calorie restriction produces very broad, sweeping changes in metabolism. The downstream changes due to mTOR inhibition only touch on a fraction of those. Thus this result may in time lead to a better understanding of which mechanisms are important in the way in which the operation of metabolism determines the pace of aging. Still, we know the scope of the benefits produced by calorie restri…
“Burnout is a sign that something needs to change.” ~Sarah Forgrave
Fifteen years ago, my doctor informed me I was in the early stages of adrenal exhaustion. In no uncertain terms, she warned that if I failed to address the stress I was under, my adrenals might not recover. This was hard to hear, but it forced me to face the fact that eating well, exercising religiously, and keeping up with the latest research on wellness was not enough.
I had to ask myself a defining question that day: Am I ready to go down with the ship?
At the time, I was teaching an average of fourteen classes a week at my wellness studio. I had been exceeding my threshold for so long that I had pain in every joint and muscle in my body. I was completely exhausted, physically, mentall…
“Burnout is a sign that something needs to change.” ~Sarah Forgrave
Fifteen years ago, my doctor informed me I was in the early stages of adrenal exhaustion. In no uncertain terms, she warned that if I failed to address the stress I was under, my adrenals might not recover. This was hard to hear, but it forced me to face the fact that eating well, exercising religiously, and keeping up with the latest research on wellness was not enough.
I had to ask myself a defining question that day: Am I ready to go down with the ship?
At the time, I was teaching an average of fourteen classes a week at my wellness studio. I had been exceeding my threshold for so long that I had pain in every joint and muscle in my body. I was completely exhausted, physically, mentall…
Today I’ll point out a review article that laments the present state of progress towards the control of inflammation in the human body. While acknowledging that great strides have been made in ways to interfere in inflammatory signaling, benefiting many patients, present tools are crude in comparison to the technologies that will most likely be needed in order to truly control unresolved, chronic inflammation and eliminate its contribution to age-related disease. True control of inflammation would imply the ability to (a) trigger resolution mechanisms with specificity, avoiding impairment of the operation of inflammation where it is needed, or at least (b) remove the lion’s share of the causes of chronic inflammation. Both seem tall orders, but one or both must be achieved.
Today I’ll point out a review article that laments the present state of progress towards the control of inflammation in the human body. While acknowledging that great strides have been made in ways to interfere in inflammatory signaling, benefiting many patients, present tools are crude in comparison to the technologies that will most likely be needed in order to truly control unresolved, chronic inflammation and eliminate its contribution to age-related disease. True control of inflammation would imply the ability to (a) trigger resolution mechanisms with specificity, avoiding impairment of the operation of inflammation where it is needed, or at least (b) remove the lion’s share of the causes of chronic inflammation. Both seem tall orders, but one or both must be achieved.
Say hello to our simplified, inspired version of Tandoori Masala! Inspired by the ingredients in the Whole Foods store-bought version of this spice mix, this easy homemade version comes together with just 6 simple ingredients in 5 minutes! It’s smoky, earthy, balanced, and perfect for seasoning chickpeas, tofu, roasted vegetables, chicken, and beyond!
What is Tandoori Masala?
A tandoor is a type ofclay oven used originally in northern India and Pakistan, and masala</…
Say hello to our simplified, inspired version of Tandoori Masala! Inspired by the ingredients in the Whole Foods store-bought version of this spice mix, this easy homemade version comes together with just 6 simple ingredients in 5 minutes! It’s smoky, earthy, balanced, and perfect for seasoning chickpeas, tofu, roasted vegetables, chicken, and beyond!
What is Tandoori Masala?
A tandoor is a type ofclay oven used originally in northern India and Pakistan, and masala</…
Mushrooms, the fruiting bodies of edible fungi, are amazing things in the kitchen, bearers of flavors that range from nutty to aromatically woody to — naturally — earthy.
With more than 10,000 types of mushrooms out there, there’s a lot to unpack when it comes to the fun guys. That’s why we asked Ian Garrone, founder of mushroom purveyor Far West Fungi in San Francisco, to guide us through the most common (and delicio…
Mushrooms, the fruiting bodies of edible fungi, are amazing things in the kitchen, bearers of flavors that range from nutty to aromatically woody to — naturally — earthy.
With more than 10,000 types of mushrooms out there, there’s a lot to unpack when it comes to the fun guys. That’s why we asked Ian Garrone, founder of mushroom purveyor Far West Fungi in San Francisco, to guide us through the most common (and delicio…
April is when Earth Month is celebrated, the culmination of which is Earth Day on the 22nd every year. And though it’s one of our favorite things to celebrate, we acknowledge our relationship and impact on the planet is 24/7. So, it’s our hope that this list of recent books helps you reconnect with nature, live more sustainably and consciously upon our one and only Earth, and live a happier life by bringing nature home — all year long.
From flower-filled recipes and connecting with your spiritual self in the garden to learning about the not-often-spoke…
April is when Earth Month is celebrated, the culmination of which is Earth Day on the 22nd every year. And though it’s one of our favorite things to celebrate, we acknowledge our relationship and impact on the planet is 24/7. So, it’s our hope that this list of recent books helps you reconnect with nature, live more sustainably and consciously upon our one and only Earth, and live a happier life by bringing nature home — all year long.
From flower-filled recipes and connecting with your spiritual self in the garden to learning about the not-often-spoke…
