Researchers working with prostate cancer cells here show that senescent cancer cells depend upon Mcl-1 to prevent programmed cell death, a novel target with existing drugs that may prove useful as general purpose senolytics, able to clear senescent cells from tissues. Cancers are highly varied, and this would have to be tested against the more usual types of senescent cell present in the aged body. Even if only applicable in the context of some cancers, however, this is still a useful discovery. Cancer survivors have <a href="https://www.fightaging.org/archives/2016/06/undergoing-chemotherapy-or-radiotherapy-is-literally-a-damaging-experience-but-are-these-consequences-a-form-of-accelerated-ag…
Researchers working with prostate cancer cells here show that senescent cancer cells depend upon Mcl-1 to prevent programmed cell death, a novel target with existing drugs that may prove useful as general purpose senolytics, able to clear senescent cells from tissues. Cancers are highly varied, and this would have to be tested against the more usual types of senescent cell present in the aged body. Even if only applicable in the context of some cancers, however, this is still a useful discovery. Cancer survivors have <a href="https://www.fightaging.org/archives/2016/06/undergoing-chemotherapy-or-radiotherapy-is-literally-a-damaging-experience-but-are-these-consequences-a-form-of-accelerated-ag…
The Less Death non-profit is founded by folk from the longevity community, with advisors that include a few of the long-standing SENS Research Foundation scientists and some of the early entrepreneurs in the longevity industry. This group is organizing a four day summer camp in June for people who want to work in the growing longevity industry. It is a good thing to make it easier to enter this part of the biotech industry, either as entrepreneurs or employees at early stage biotech companies. The focus is on education, but building a network of connections with those already involved in the industry is the real benefit to this sort of meeting.
Less Death is a nonprofit with the mission to support the growth and effectiveness of the longevity industry’s workforce. We help aspiring longevity engineers start or advance their career by providing education, career guidance, mentorshi…
The Less Death non-profit is founded by folk from the longevity community, with advisors that include a few of the long-standing SENS Research Foundation scientists and some of the early entrepreneurs in the longevity industry. This group is organizing a four day summer camp in June for people who want to work in the growing longevity industry. It is a good thing to make it easier to enter this part of the biotech industry, either as entrepreneurs or employees at early stage biotech companies. The focus is on education, but building a network of connections with those already involved in the industry is the real benefit to this sort of meeting.
Less Death is a nonprofit with the mission to support the growth and effectiveness of the longevity industry’s workforce. We help aspiring longevity engineers start or advance their career by providing education, career guidance, mentorshi…
I’ve noticed that a lot of us will be pretty wiped out at the end of a long day of work or social activity, to the point where we need time to recuperate from exhaustion. There’s nothing wrong with that, but let’s talk about the possibility of doing hard things without exhausting ourselves.
We might call it Effortless Effort (similar to “wu wei” in Daoism) — the idea of acting without a huge amount of tension or extraneous physical effort.
When you talk to someone about “trying hard,” they usually will put a lot of energy into something, and quickly exhaust themselves. “Trying hard” is equated to being very tense, pushing hard with your body and mind, and putting everything you have into it.
If you talk to someone about “relaxing,” they will usually think of that as the opposite of “trying hard.” They think of lying on the couch, muscles relaxed, not doing anythin…
I’ve noticed that a lot of us will be pretty wiped out at the end of a long day of work or social activity, to the point where we need time to recuperate from exhaustion. There’s nothing wrong with that, but let’s talk about the possibility of doing hard things without exhausting ourselves.
We might call it Effortless Effort (similar to “wu wei” in Daoism) — the idea of acting without a huge amount of tension or extraneous physical effort.
When you talk to someone about “trying hard,” they usually will put a lot of energy into something, and quickly exhaust themselves. “Trying hard” is equated to being very tense, pushing hard with your body and mind, and putting everything you have into it.
If you talk to someone about “relaxing,” they will usually think of that as the opposite of “trying hard.” They think of lying on the couch, muscles relaxed, not doing anythin…
“Ask for help. Not because you are weak. But because you want to remain strong.” ~Les Brown
I sat in the doctor’s office, waiting—linen gown hanging off me, half exposed—while going through the checklist in my mind of what I needed help with. I felt my breathing go shallow as I mentally sorted through the aches and pains I couldn’t seem to control.
Fierce independence and learning to not rely on others are two of the side effects of my particular trauma wounds, stemming from early childhood neglect and abandonment. During times of heightened stress, my default state is one of significant distrust.
Letting people in and asking for help has never been my strong suit.
“Ask for help. Not because you are weak. But because you want to remain strong.” ~Les Brown
I sat in the doctor’s office, waiting—linen gown hanging off me, half exposed—while going through the checklist in my mind of what I needed help with. I felt my breathing go shallow as I mentally sorted through the aches and pains I couldn’t seem to control.
Fierce independence and learning to not rely on others are two of the side effects of my particular trauma wounds, stemming from early childhood neglect and abandonment. During times of heightened stress, my default state is one of significant distrust.
Letting people in and asking for help has never been my strong suit.
Blackheads and whiteheads and cysts, oh my! No matter what type of acne you have, pimples are the pits. But don’t worry, gorgeous! With a little makeup magic, you can make your zits disappear. Well, almost.
Here’s everything you need to know about covering up acne with makeup.
Blackheads and whiteheads and cysts, oh my! No matter what type of acne you have, pimples are the pits. But don’t worry, gorgeous! With a little makeup magic, you can make your zits disappear. Well, almost.
Here’s everything you need to know about covering up acne with makeup.
In today’s open access paper, researchers presented data on the pace at which random mutational damage accumulates in the nuclear DNA of somatic cells over a lifetime, covering a range of mammalian species with differing body sizes and life spans. They looked only at the lining of the gut, a tissue in which cells replicate rapidly, and thus one might expect to find more mutations and thus data that is more easily analyzed. The researchers found that the burden of mutations in late life is remarkably consistent, the rate of mutation inversely correlated with species life span. This is suggestive that somatic mutations are either an important contributing cause of aging, or a side-effect that is strongly connected to an important contributing cause of aging.
How could random mutational damage in cells throughout the body contribute to aging? Most of that dam…
In today’s open access paper, researchers presented data on the pace at which random mutational damage accumulates in the nuclear DNA of somatic cells over a lifetime, covering a range of mammalian species with differing body sizes and life spans. They looked only at the lining of the gut, a tissue in which cells replicate rapidly, and thus one might expect to find more mutations and thus data that is more easily analyzed. The researchers found that the burden of mutations in late life is remarkably consistent, the rate of mutation inversely correlated with species life span. This is suggestive that somatic mutations are either an important contributing cause of aging, or a side-effect that is strongly connected to an important contributing cause of aging.
How could random mutational damage in cells throughout the body contribute to aging? Most of that dam…
Everyone wants to be liked. The acceptance and approval of people around us light up our oxytocin receptors, nurturing feelings of safety, bonding, and lower anxiety.
“Humans, by nature, are social beings who crave connection, intimacy, and relationships with others,” says Amy Kaplan, a licensed therapist with PlushCare. “Caring about what others think of us is part of that desire to make connections and feel accepted.”
But what if you’ve started putting too much value on the opinions of strangers and acquaintances? If caring what other people think is holding you back, we have some expert tips to help you care less.
Everyone wants to be liked. The acceptance and approval of people around us light up our oxytocin receptors, nurturing feelings of safety, bonding, and lower anxiety.
“Humans, by nature, are social beings who crave connection, intimacy, and relationships with others,” says Amy Kaplan, a licensed therapist with PlushCare. “Caring about what others think of us is part of that desire to make connections and feel accepted.”
But what if you’ve started putting too much value on the opinions of strangers and acquaintances? If caring what other people think is holding you back, we have some expert tips to help you care less.
The longest lived mice are those in which growth hormone or growth hormone receptor are knocked out, a gain of 70% or so in life span. They exhibit dwarfism, like the human population with the analogous inherited Laron syndrome, caused by a loss-of-function mutation in growth hormone receptor. The Laron syndrome population may be somewhat more resistant to some age-related diseases, that data still to be rigorously confirmed, but do not appear to live any longer than the rest of us. Studies on growth hormone metabolism and longevity conducted in mice should be read with that in mi…
The longest lived mice are those in which growth hormone or growth hormone receptor are knocked out, a gain of 70% or so in life span. They exhibit dwarfism, like the human population with the analogous inherited Laron syndrome, caused by a loss-of-function mutation in growth hormone receptor. The Laron syndrome population may be somewhat more resistant to some age-related diseases, that data still to be rigorously confirmed, but do not appear to live any longer than the rest of us. Studies on growth hormone metabolism and longevity conducted in mice should be read with that in mi…
Dinner made on 1 pan with 7 ingredients? That’s our kind of meal! This sheet pan dinner features crumbled tofu, tender roasted vegetables, and our Indian-inspired tandoori spice mix. It’s flavorful, oh so satisfying, and plant-based, and we’re in love with how simple and versatile it is!
If you don’t have the exact veggies we used, use what you have for an empty-the-fridge party (Can we come?).
Dinner made on 1 pan with 7 ingredients? That’s our kind of meal! This sheet pan dinner features crumbled tofu, tender roasted vegetables, and our Indian-inspired tandoori spice mix. It’s flavorful, oh so satisfying, and plant-based, and we’re in love with how simple and versatile it is!
If you don’t have the exact veggies we used, use what you have for an empty-the-fridge party (Can we come?).
