Source https://www.fightaging.org/archives/2021/01/a-few-more-mammalian-species-found-to-exhibit-amyloid-%CE%B2-and-tau-pathology/
The primary challenge in Alzheimer’s disease research has long been that short-lived laboratory species do not naturally exhibit any of the features of the condition. Thus all mouse models of the condition are highly artificial genetic constructs, and potential treatments and relevant mechanisms in these models have a high chance of being irrelevant to Alzheimer’s disease as it exists in humans. Up until fairly recently it could be argued that humans were in fact the only species to exhibit full blown Alzheimer’s disease, involving a lengthy increase in amyloid-β aggregation in the brain, followed by neuroinflammation, tau aggregation, and widespread cell death.
However, in…
Source https://www.fightaging.org/archives/2021/01/a-few-more-mammalian-species-found-to-exhibit-amyloid-%CE%B2-and-tau-pathology/
The primary challenge in Alzheimer’s disease research has long been that short-lived laboratory species do not naturally exhibit any of the features of the condition. Thus all mouse models of the condition are highly artificial genetic constructs, and potential treatments and relevant mechanisms in these models have a high chance of being irrelevant to Alzheimer’s disease as it exists in humans. Up until fairly recently it could be argued that humans were in fact the only species to exhibit full blown Alzheimer’s disease, involving a lengthy increase in amyloid-β aggregation in the brain, followed by neuroinflammation, tau aggregation, and widespread cell death.
However, in…
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