Nonalcoholic steatohepatitis, NASH, is a condition characterized by chronic inflammation and fibrosis in the liver. Fibrosis is a malfunction of tissue maintenance, the deposition of excessive, scar-like collagen that disrupts tissue structure and function. Like all fibrotic diseases, means of effectively reversing the progression of NASH are presently lacking. NASH is a lifestyle condition, a consequence of fatty liver and obesity, but losing weight and otherwise changing lifestyle will not significantly reverse established fibrosis and loss of liver function. Where fibrosis and inflammation characterize a condition, we might by now expect <a href=…
Implicating Cellular Senescence in the Fibrosis and Inflammation of NASH
Nonalcoholic steatohepatitis, NASH, is a condition characterized by chronic inflammation and fibrosis in the liver. Fibrosis is a malfunction of tissue maintenance, the deposition of excessive, scar-like collagen that disrupts tissue structure and function. Like all fibrotic diseases, means of effectively reversing the progression of NASH are presently lacking. NASH is a lifestyle condition, a consequence of fatty liver and obesity, but losing weight and otherwise changing lifestyle will not significantly reverse established fibrosis and loss of liver function. Where fibrosis and inflammation characterize a condition, we might by now expect <a href=…