Source https://www.fightaging.org/archives/2020/06/reuse-of-a-small-molecule-to-increase-autophagy-in-the-brain-is-trialed-for-alzheimers-disease/
Today I’ll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn’t made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of small molecule compounds there are some that result in increased autophagy – the question is always whether the side-effects are tolerable.
The cancer research community in particula…
Source https://www.fightaging.org/archives/2020/06/reuse-of-a-small-molecule-to-increase-autophagy-in-the-brain-is-trialed-for-alzheimers-disease/
Today I’ll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn’t made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of small molecule compounds there are some that result in increased autophagy – the question is always whether the side-effects are tolerable.
The cancer research community in particula…
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