A great many projects at various stages of development are characterized by their goal of forcing greater stem cell activity in old tissues, but without meaningfully addressing the underlying causes of stem cell decline in later life. This sort of research and development operates at the level of proximate causes, adjusting protein levels to change cell behavior. Among the potential therapies I’d place into this category: telomerase gene therapy; GDF11 upregulation; FGF2 inhibition; <a…
Targeting GAS1 to Put Muscle Stem Cells Back to Work in Old Tissues
A great many projects at various stages of development are characterized by their goal of forcing greater stem cell activity in old tissues, but without meaningfully addressing the underlying causes of stem cell decline in later life. This sort of research and development operates at the level of proximate causes, adjusting protein levels to change cell behavior. Among the potential therapies I’d place into this category: telomerase gene therapy; GDF11 upregulation; FGF2 inhibition; <a…