Demonstrating an mRNA Cancer Vaccine

Source https://www.fightaging.org/archives/2024/05/demonstrating-an-mrna-cancer-vaccine/

One of the consequences of the COVID-19 pandemic is that the biotech industry is now geared up for the use of messenger RNA (mRNA) as a basis for therapy. The broadest use at present is vaccination, as doses can be very low and the experience gained during the pandemic is directly applicable, but many other forms of mRNA gene therapy are under development. Given the ability to produce novel mRNA vaccines, the most obvious use beyond infectious disease is to force the immune system to engage with cancerous tissue. This line of development appears to be making good progress.

In a first-ever human clinical trial of four adult patients, an mRNA <a href="https://…

Source https://www.fightaging.org/archives/2024/05/demonstrating-an-mrna-cancer-vaccine/

One of the consequences of the COVID-19 pandemic is that the biotech industry is now geared up for the use of messenger RNA (mRNA) as a basis for therapy. The broadest use at present is vaccination, as doses can be very low and the experience gained during the pandemic is directly applicable, but many other forms of mRNA gene therapy are under development. Given the ability to produce novel mRNA vaccines, the most obvious use beyond infectious disease is to force the immune system to engage with cancerous tissue. This line of development appears to be making good progress.

In a first-ever human clinical trial of four adult patients, an mRNA <a href="https://…

Exosome Therapy as a Way to Improve Angiogenesis in the Context of Bone Tissue

Source https://www.fightaging.org/archives/2024/05/exosome-therapy-as-a-way-to-improve-angiogenesis-in-the-context-of-bone-tissue/

Angiogenesis, the complex set of processes by which new blood vessels are produced, becomes less efficient with advancing age. One important consequence is a loss of capillary density, which has a range of detrimental effects on tissue function, particularly in energy-hungry tissues such as the brain and muscle. Regeneration from injury is also dependent on the quality and efficiency of angiogenesis. Researchers here take a narrow focus on the question of angiogenesis relevant to bone tissue maintenance and regeneration, and the use of exosome therapies to improve angiogenesis. To the degree that treatment with exosomes harvested from stem cells can improve angiogenesis throughout the body, this approach to therapy shou…

Source https://www.fightaging.org/archives/2024/05/exosome-therapy-as-a-way-to-improve-angiogenesis-in-the-context-of-bone-tissue/

Angiogenesis, the complex set of processes by which new blood vessels are produced, becomes less efficient with advancing age. One important consequence is a loss of capillary density, which has a range of detrimental effects on tissue function, particularly in energy-hungry tissues such as the brain and muscle. Regeneration from injury is also dependent on the quality and efficiency of angiogenesis. Researchers here take a narrow focus on the question of angiogenesis relevant to bone tissue maintenance and regeneration, and the use of exosome therapies to improve angiogenesis. To the degree that treatment with exosomes harvested from stem cells can improve angiogenesis throughout the body, this approach to therapy shou…

The Gift of Self-Acceptance: Goodbye Filters, Hello Authentic Self

Source https://tinybuddha.com/blog/the-gift-of-self-acceptance-goodbye-filters-hello-authentic-self/

“Beauty doesn’t come from physical perfection. It comes from the light in our eyes, the spark in our hearts, and the radiance we exude when we’re comfortable enough in our skin to focus less on how we look and more on how we love.” ~Lori Deschene

Swiping though the various filters available, I saw my face go from mine to someone else’s—to someone with better skin, bigger eyes… Oooh look, I think this one makes my face look slimmer. Hello, cheekbones!

As someone who hated having her picture taken and was utterly convinced that she looked beyond awful in photos, I suddenly saw an easy fix to look good on camera.

When I first started showing up online for my busin…

Source https://tinybuddha.com/blog/the-gift-of-self-acceptance-goodbye-filters-hello-authentic-self/

“Beauty doesn’t come from physical perfection. It comes from the light in our eyes, the spark in our hearts, and the radiance we exude when we’re comfortable enough in our skin to focus less on how we look and more on how we love.” ~Lori Deschene

Swiping though the various filters available, I saw my face go from mine to someone else’s—to someone with better skin, bigger eyes… Oooh look, I think this one makes my face look slimmer. Hello, cheekbones!

As someone who hated having her picture taken and was utterly convinced that she looked beyond awful in photos, I suddenly saw an easy fix to look good on camera.

When I first started showing up online for my busin…

Cellular Senescence in the Aging Kidney

Source https://www.fightaging.org/archives/2024/05/cellular-senescence-in-the-aging-kidney/

Much of past research into age-related disease involves looking at changes in gene expression in the diseased organ, a very low-level laundry list of alterations. This is somewhat decoupled from the approach of looking at changes in cell behavior, a high-level laundry list of alterations. A sizable fraction of life science research involves trying to make firm connections between these two sets of data, to better steer development efforts towards interfering in more relevant rather than less relevant mechanisms. Here, as an example of this sort of work, researchers link PAR2 expression in the kidney to cellular senescence in that organ. Senescent cells accumulate with age to produce <a href="https://www.fightaging.org/archives/2016/08/considering-the-mechanisms-and-treatment-of-inflamma…

Source https://www.fightaging.org/archives/2024/05/cellular-senescence-in-the-aging-kidney/

Much of past research into age-related disease involves looking at changes in gene expression in the diseased organ, a very low-level laundry list of alterations. This is somewhat decoupled from the approach of looking at changes in cell behavior, a high-level laundry list of alterations. A sizable fraction of life science research involves trying to make firm connections between these two sets of data, to better steer development efforts towards interfering in more relevant rather than less relevant mechanisms. Here, as an example of this sort of work, researchers link PAR2 expression in the kidney to cellular senescence in that organ. Senescent cells accumulate with age to produce <a href="https://www.fightaging.org/archives/2016/08/considering-the-mechanisms-and-treatment-of-inflamma…

The Contribution of Adaptive Immune System Aging to Atherosclerosis

Source https://www.fightaging.org/archives/2024/05/the-contribution-of-adaptive-immune-system-aging-to-atherosclerosis/

Atherosclerosis is the buildup of fatty plaques in blood vessel walls that narrow and weaken those vessels, leading to rupture and a heart attack or stroke. While it is the innate immune cells known as macrophages that are responsible for removing excess lipids from blood vessel walls, clearing up the damage that leads to atherosclerotic plaques, atherosclerosis is a broadly inflammatory condition. Any contribution to systemic inflammatory signaling makes it harder for macrophages to do their job, and the aged adaptive immune system is just as much a source of inflammatio…

Source https://www.fightaging.org/archives/2024/05/the-contribution-of-adaptive-immune-system-aging-to-atherosclerosis/

Atherosclerosis is the buildup of fatty plaques in blood vessel walls that narrow and weaken those vessels, leading to rupture and a heart attack or stroke. While it is the innate immune cells known as macrophages that are responsible for removing excess lipids from blood vessel walls, clearing up the damage that leads to atherosclerotic plaques, atherosclerosis is a broadly inflammatory condition. Any contribution to systemic inflammatory signaling makes it harder for macrophages to do their job, and the aged adaptive immune system is just as much a source of inflammatio…

Stochastic Changes are Sufficient to Produce the Behavior of Aging Clocks

Source https://www.fightaging.org/archives/2024/05/stochastic-changes-are-sufficient-to-produce-the-behavior-of-aging-clocks/

That it is possible to produce aging clocks from omics data, that some omics changes map very well to chronological age, biological age, and risk and presence of age-related disease, has been used to argue for aging to be an evolved program. Researchers here use a modeling approach to show that random events, the accumulation of molecular damage, can still produce the outcome observed in aging clocks.

Aging clocks have provided one of the most important recent breakthroughs in the biology of aging, and may provide indicators for the effectiveness of interventions in the aging process and preventive treatments for age-related diseases. The re…

Source https://www.fightaging.org/archives/2024/05/stochastic-changes-are-sufficient-to-produce-the-behavior-of-aging-clocks/

That it is possible to produce aging clocks from omics data, that some omics changes map very well to chronological age, biological age, and risk and presence of age-related disease, has been used to argue for aging to be an evolved program. Researchers here use a modeling approach to show that random events, the accumulation of molecular damage, can still produce the outcome observed in aging clocks.

Aging clocks have provided one of the most important recent breakthroughs in the biology of aging, and may provide indicators for the effectiveness of interventions in the aging process and preventive treatments for age-related diseases. The re…

Correlating Gut Microbiome Characteristics with Changed Behavior in Aging Mice

Source https://www.fightaging.org/archives/2024/05/correlating-gut-microbiome-characteristics-with-changed-behavior-in-aging-mice/

The composition of the gut microbiome influences health and aging. In addition to variations between individuals, the relative abundances of different microbial populations making up the gut microbiome change with age in ways that contribute to chronic inflammation and the loss of useful metabolite production. Researchers here demonstrate that it is possible to correlate aspects of this gut microbiome aging with changes in behavior normally observed in aged mice. The gut microbiome is becoming an attractive target for intervention, given that strategies such as

Source https://www.fightaging.org/archives/2024/05/correlating-gut-microbiome-characteristics-with-changed-behavior-in-aging-mice/

The composition of the gut microbiome influences health and aging. In addition to variations between individuals, the relative abundances of different microbial populations making up the gut microbiome change with age in ways that contribute to chronic inflammation and the loss of useful metabolite production. Researchers here demonstrate that it is possible to correlate aspects of this gut microbiome aging with changes in behavior normally observed in aged mice. The gut microbiome is becoming an attractive target for intervention, given that strategies such as

Tracing Contributions to Neuroinflammation Back to the Bone Marrow

Source https://www.fightaging.org/archives/2024/05/tracing-contributions-to-neuroinflammation-back-to-the-bone-marrow/

In today’s open access paper, researchers discuss the role of bone marrow aging in the chronic inflammation observed in the aging brain. This inflammation is clearly of great importance in the onset and development of neurodegenerative conditions such as Alzheimer’s disease; it is disruptive to the function of the brain. The immune system of the body originates in the hematopoietic cell populations of bone marrow, where cells of the innate immune system are created, as well as the thymocyte precursors to <a href="https://en.wikipedia.org/wiki/Adaptive_immune…

Source https://www.fightaging.org/archives/2024/05/tracing-contributions-to-neuroinflammation-back-to-the-bone-marrow/

In today’s open access paper, researchers discuss the role of bone marrow aging in the chronic inflammation observed in the aging brain. This inflammation is clearly of great importance in the onset and development of neurodegenerative conditions such as Alzheimer’s disease; it is disruptive to the function of the brain. The immune system of the body originates in the hematopoietic cell populations of bone marrow, where cells of the innate immune system are created, as well as the thymocyte precursors to <a href="https://en.wikipedia.org/wiki/Adaptive_immune…

How to Stop Prioritizing Everyone and Everything Else at Your Own Expense

Source https://tinybuddha.com/blog/how-to-stop-prioritizing-everyone-and-everything-else-at-your-own-expense/

“Agreeing to things just to keep the peace is actually a trauma response. When you do this you’re disrespecting your boundaries. No more making yourself uncomfortable for others to feel comfortable. You have control now. You run your life. Take up space and use your voice.” ~Dj Love Light

I read the text from my stepmother inviting everyone to the holiday dinner at her house, and my stomach began to churn. I did not want to attend, but I was instantly flooded with guilt at the thought of saying no.

“How to kindly decline an invite” I typed and hit search.

I felt like I should go to their dinner, even though I didn’t want to. My stepparents were always disappointed when som…

Source https://tinybuddha.com/blog/how-to-stop-prioritizing-everyone-and-everything-else-at-your-own-expense/

“Agreeing to things just to keep the peace is actually a trauma response. When you do this you’re disrespecting your boundaries. No more making yourself uncomfortable for others to feel comfortable. You have control now. You run your life. Take up space and use your voice.” ~Dj Love Light

I read the text from my stepmother inviting everyone to the holiday dinner at her house, and my stomach began to churn. I did not want to attend, but I was instantly flooded with guilt at the thought of saying no.

“How to kindly decline an invite” I typed and hit search.

I felt like I should go to their dinner, even though I didn’t want to. My stepparents were always disappointed when som…

Ask Joan – A Ten Year Retrospective

Source https://seniorplanet.org/articles-ask-joan-ten-years/

Happy Anniversary! Joan Price reflects on ten years of her Sex and Relationships advice column for Senior Planet.

The post Ask Joan – A Ten Year Retrospective appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-ask-joan-ten-years/

Happy Anniversary! Joan Price reflects on ten years of her Sex and Relationships advice column for Senior Planet.

The post Ask Joan – A Ten Year Retrospective appeared first on Senior Planet from AARP.

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