The longest lived mice to date are those in which growth hormone signaling is disrupted, such as via growth hormone receptor knockout. While larger species tend to be longer lived, within a given mammalian species greater body size (and thus greater growth hormone activity) appears to reduce life expectancy. The effect is much more pronounced in short-lived species such as mice than in long-lived species such as our own, however. An inherited loss of function mutation in growth hormone receptor in humans produces Laron syndrome in a small population, but these individuals do not appear to live any longer than the rest of us.
The longest lived mice to date are those in which growth hormone signaling is disrupted, such as via growth hormone receptor knockout. While larger species tend to be longer lived, within a given mammalian species greater body size (and thus greater growth hormone activity) appears to reduce life expectancy. The effect is much more pronounced in short-lived species such as mice than in long-lived species such as our own, however. An inherited loss of function mutation in growth hormone receptor in humans produces Laron syndrome in a small population, but these individuals do not appear to live any longer than the rest of us.
JK, but srsly — though research is still in its early phases, scientists think cannabidiol (aka CBD) could possibly provide relief for anxiety, insomnia, pain, IBS, and various mood disorders. We need more research to know…
JK, but srsly — though research is still in its early phases, scientists think cannabidiol (aka CBD) could possibly provide relief for anxiety, insomnia, pain, IBS, and various mood disorders. We need more research to know…
The gut microbiome is important in long-term health. At a guess, its influence on health may be on a par with, say, the state of physical fitness exhibited by an individual. The relative sizes of microbial populations change over a lifetime, and in detrimental ways. Inflammatory microbes and those producing harmful metabolites increase in number, while useful metabolite production declines. This occurs for a range of reasons, easy enough to list, but hard to put in an order of relative importance. For example, the …
The gut microbiome is important in long-term health. At a guess, its influence on health may be on a par with, say, the state of physical fitness exhibited by an individual. The relative sizes of microbial populations change over a lifetime, and in detrimental ways. Inflammatory microbes and those producing harmful metabolites increase in number, while useful metabolite production declines. This occurs for a range of reasons, easy enough to list, but hard to put in an order of relative importance. For example, the …
“Growth is uncomfortable because you’ve never been here before. You’ve never seen this version of you. So give yourself a little grace and breathe through it.” ~Kristin Lohr
I was kinda sorta showing up.
To the outside world, it looked like I was doing all of the things. I was smiling. I was talking about exercise and eating well. I was posting happy, positive vibe quotes, but I wasn’t really showing up for myself.
I had experienced a miscarriage at thirteen weeks. This was supposed to be the safe zone. I had told family and friends. My husband and I even had names ready to go. This was baby number four, so I thought I was a pro.
I was in a toxic work environment, but I kept going. Even after my miscarriage, I felt I had to be back there quickly so …
“Growth is uncomfortable because you’ve never been here before. You’ve never seen this version of you. So give yourself a little grace and breathe through it.” ~Kristin Lohr
I was kinda sorta showing up.
To the outside world, it looked like I was doing all of the things. I was smiling. I was talking about exercise and eating well. I was posting happy, positive vibe quotes, but I wasn’t really showing up for myself.
I had experienced a miscarriage at thirteen weeks. This was supposed to be the safe zone. I had told family and friends. My husband and I even had names ready to go. This was baby number four, so I thought I was a pro.
I was in a toxic work environment, but I kept going. Even after my miscarriage, I felt I had to be back there quickly so …
The Census knows the growth and potential explosion of care needs and older adults. Consider their newly published document explaining the industries to those who may still not see what’s happening. “Assisted Living Facilities for the Elderly saw a 34.4% increase in revenue from 2013 to 2020. Home Health Care Services experienced an even larger increase – 50.5% — during the same period.” These assertions are built on the <a href="https://www.census.gov/programs-surveys/sas.h…
The Census knows the growth and potential explosion of care needs and older adults. Consider their newly published document explaining the industries to those who may still not see what’s happening. “Assisted Living Facilities for the Elderly saw a 34.4% increase in revenue from 2013 to 2020. Home Health Care Services experienced an even larger increase – 50.5% — during the same period.” These assertions are built on the <a href="https://www.census.gov/programs-surveys/sas.h…
“You live as if you were destined to live forever, no thought of your frailty ever enters your head, of how much time has already gone by you take no heed. You squander time as if you drew from a full and abundant supply, though all the while that day which you bestow on some person or thing is perhaps your last.”
We could use a daily contemplation on how limited our time is in this life. Most of us avoid thinking about it, or get worked up or sad when we think about it. But it’s a powerful contemplation.
Today I’d like to share a series of brief contemplations on the shortness of life, that I find valuable.
1:
We could ignore the very limited nature of this life, and take it for granted, and find ourselves at the end of our lives with regret that we didn’t use it more wisely.
“You live as if you were destined to live forever, no thought of your frailty ever enters your head, of how much time has already gone by you take no heed. You squander time as if you drew from a full and abundant supply, though all the while that day which you bestow on some person or thing is perhaps your last.”
We could use a daily contemplation on how limited our time is in this life. Most of us avoid thinking about it, or get worked up or sad when we think about it. But it’s a powerful contemplation.
Today I’d like to share a series of brief contemplations on the shortness of life, that I find valuable.
1:
We could ignore the very limited nature of this life, and take it for granted, and find ourselves at the end of our lives with regret that we didn’t use it more wisely.
Whether you’re a New Orleans native or are just passing through, you’re near-guaranteed to run into two classic dishes: gumbo and jambalaya. These two Southern staples are both flavorful, hearty dishes associated with the Big Easy — and we wouldn’t turn down either — but what exactly is the difference between the two?
We’re breaking down the subtle contrasts between these iconic Southern stews.
What is gumbo?
Gumbo is a Creole dish descended from many different culinary heritages. A very hearty soup …
Whether you’re a New Orleans native or are just passing through, you’re near-guaranteed to run into two classic dishes: gumbo and jambalaya. These two Southern staples are both flavorful, hearty dishes associated with the Big Easy — and we wouldn’t turn down either — but what exactly is the difference between the two?
We’re breaking down the subtle contrasts between these iconic Southern stews.
What is gumbo?
Gumbo is a Creole dish descended from many different culinary heritages. A very hearty soup …