Theorizing on Why the Heart Is Not Regenerative

Source https://www.fightaging.org/archives/2022/12/theorizing-on-why-the-heart-is-not-regenerative/

After the central nervous system, heart muscle is one of the least capable tissues in the body when it comes to regeneration following injury. This is one of the contributing factors to the downward spiral of heart health in later life, particularly the cell death and scarring that occurs following the ischemia of a heart attack. Researchers here suggest that this lack of regenerative capacity is the rest of an adaptation in the nuclear membrane that protects heart cells from other damaging circumstances by reducing the number of pathways that allow signal molecules to pass into the cell nucleus. That is protective against harmful signals, but also interferes in the signaling necess…

Source https://www.fightaging.org/archives/2022/12/theorizing-on-why-the-heart-is-not-regenerative/

After the central nervous system, heart muscle is one of the least capable tissues in the body when it comes to regeneration following injury. This is one of the contributing factors to the downward spiral of heart health in later life, particularly the cell death and scarring that occurs following the ischemia of a heart attack. Researchers here suggest that this lack of regenerative capacity is the rest of an adaptation in the nuclear membrane that protects heart cells from other damaging circumstances by reducing the number of pathways that allow signal molecules to pass into the cell nucleus. That is protective against harmful signals, but also interferes in the signaling necess…

Classic Vegan Gluten-Free Chocolate Chip Cookies

Source https://minimalistbaker.com/vegan-gluten-free-chocolate-chip-cookies/

Classic Vegan Gluten-Free Chocolate Chip Cookies

We’re no strangers to chocolate chip cookies (exhibits A, B, C, D, and E), but we were missing a more classic version of this timeless treat. Not anymore! Meet decadent vegan and gluten-free chocolate chip cookies with chewy, tender centers and crispy edges

Made in 1 bowl with just 8 ingredients and a quick chill time, these buttery, caramelly cookies will satisfy your cookie craving in no time!

<…

Source https://minimalistbaker.com/vegan-gluten-free-chocolate-chip-cookies/

Classic Vegan Gluten-Free Chocolate Chip Cookies

We’re no strangers to chocolate chip cookies (exhibits A, B, C, D, and E), but we were missing a more classic version of this timeless treat. Not anymore! Meet decadent vegan and gluten-free chocolate chip cookies with chewy, tender centers and crispy edges

Made in 1 bowl with just 8 ingredients and a quick chill time, these buttery, caramelly cookies will satisfy your cookie craving in no time!

<…

Italian Herb Tofu & Winter Vegetable Sheet Pan Meal

Source https://minimalistbaker.com/italian-tofu-veggie-sheet-pan-meal/

Italian Herb Tofu & Winter Vegetable Sheet Pan Meal

Boring weeknight dinners, step aside! This savory, satisfying sheet pan meal, inspired by our fan-favorite Crispy Baked Tofu with Italian Herbs, combines caramelized roasted veggies with crumbled tofu and a tahini or garlicky hummus sauce. 

The result is a nourishing vegan and gluten-free meal made with just 10 ingredients. Easy to make and packed with plant-based protein, this will become one of your go-tos! The best part?

<a href="https://minimalistbaker.com/italian-tofu-veggie-sheet-pan-meal/"…

Source https://minimalistbaker.com/italian-tofu-veggie-sheet-pan-meal/

Italian Herb Tofu & Winter Vegetable Sheet Pan Meal

Boring weeknight dinners, step aside! This savory, satisfying sheet pan meal, inspired by our fan-favorite Crispy Baked Tofu with Italian Herbs, combines caramelized roasted veggies with crumbled tofu and a tahini or garlicky hummus sauce. 

The result is a nourishing vegan and gluten-free meal made with just 10 ingredients. Easy to make and packed with plant-based protein, this will become one of your go-tos! The best part?

<a href="https://minimalistbaker.com/italian-tofu-veggie-sheet-pan-meal/"…

Senior Planet Talks To…Nick Nolte

Source https://seniorplanet.org/senior-planet-talks-to-nick-nolte/

Three-time Oscar nominee Nick Nolte talks exclusively to Senior Planet about his favorite roles, current projects, and about working with Katherine Hepburn.

The post Senior Planet Talks To…Nick Nolte appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/senior-planet-talks-to-nick-nolte/

Three-time Oscar nominee Nick Nolte talks exclusively to Senior Planet about his favorite roles, current projects, and about working with Katherine Hepburn.

The post Senior Planet Talks To…Nick Nolte appeared first on Senior Planet from AARP.

Vascular Smooth Muscle Cells Become Prone to Altered Behavior with Age

Source https://www.fightaging.org/archives/2022/12/vascular-smooth-muscle-cells-become-prone-to-altered-behavior-with-age/

The altered signaling environment in aged tissue produces changes in cell behavior, some of which is adaptive and helpful, and some of which is maladaptive and harmful. In some cases the same process can be one or the other depending on context. Cellular senescence, for example, is helpful in the contexts of cancer suppression and regeneration from injury, but only up until the point at which senescent cells are no longer removed as rapidly as they are created, at which point their continued, unrelenting <a href="https://en.wikipedia.org/wiki/Senesc…

Source https://www.fightaging.org/archives/2022/12/vascular-smooth-muscle-cells-become-prone-to-altered-behavior-with-age/

The altered signaling environment in aged tissue produces changes in cell behavior, some of which is adaptive and helpful, and some of which is maladaptive and harmful. In some cases the same process can be one or the other depending on context. Cellular senescence, for example, is helpful in the contexts of cancer suppression and regeneration from injury, but only up until the point at which senescent cells are no longer removed as rapidly as they are created, at which point their continued, unrelenting <a href="https://en.wikipedia.org/wiki/Senesc…

Rise Up! 6 Best Substitutes for Baking Soda

Source https://greatist.com/eat/substitutes-for-baking-soda

Baking soda (aka sodium bicarbonate) is a vital ingredient in tons of baked goods. If you don’t have any on hand, you can use a substitute instead.

Baking soda helps take cakes, cookies, muffins, and more from flat to fluffy. But what do you do if you don’t have any baking soda on hand? Don’t fret. Your baked goodies can still come out amazing with the help of a baking soda substitute.

The six best alternatives to baking soda are:

  1. Baking powder
  2. Self-ri…

Source https://greatist.com/eat/substitutes-for-baking-soda

Baking soda (aka sodium bicarbonate) is a vital ingredient in tons of baked goods. If you don’t have any on hand, you can use a substitute instead.

Baking soda helps take cakes, cookies, muffins, and more from flat to fluffy. But what do you do if you don’t have any baking soda on hand? Don’t fret. Your baked goodies can still come out amazing with the help of a baking soda substitute.

The six best alternatives to baking soda are:

  1. Baking powder
  2. Self-ri…

11 Tips to Help You Stick to Your New Year's Goals

Source https://greatist.com/happiness/new-year-goal-setting

Setting New Year resolutions can help you achieve success in the upcoming year. However, sticking to your goals can get hard as the year marches on. The right game plan can help you stay the course all-year long.

Lots of peeps kick off January with high hopes of good behavior and achievements, but lose momentum as the year marches on. In fact, only 4 in 10 peeps are still on track with their resolutions after six months.

But that doesn’t have to be your reality in 2023. Sure, if your goal-setting process is flawed, you’re unlikely to get very far. The good news is that with a few tweaks, you can make sure your resolutions stick around and become part of your routine. The key is to set realistic, attainable goals and to break down those grandiose resolutions into smaller parts.

K…

Source https://greatist.com/happiness/new-year-goal-setting

Setting New Year resolutions can help you achieve success in the upcoming year. However, sticking to your goals can get hard as the year marches on. The right game plan can help you stay the course all-year long.

Lots of peeps kick off January with high hopes of good behavior and achievements, but lose momentum as the year marches on. In fact, only 4 in 10 peeps are still on track with their resolutions after six months.

But that doesn’t have to be your reality in 2023. Sure, if your goal-setting process is flawed, you’re unlikely to get very far. The good news is that with a few tweaks, you can make sure your resolutions stick around and become part of your routine. The key is to set realistic, attainable goals and to break down those grandiose resolutions into smaller parts.

K…

A Gentle Reminder to Anyone Who’s Struggling This Holiday Season

Source https://tinybuddha.com/blog/a-gentle-reminder-to-anyone-whos-struggling-this-holiday-season/

“It’s okay to want to be alone. It’s okay to take time for yourself.” ~Kate Allan

It’s the holiday season, the most wonderful time of the year, they say, but it’s not for all of us. For those of us coping with the loss of a loved one, family estrangement, loneliness, financial difficulties, or health struggles, the holidays can be one of the hardest times of the year.

For some of us the holidays can feel as if we have been cast out in the cold. As if we are forced to look through a window of a happy, loving family.

Many of us are filled with feelings of longing for things that can never be, such as more time with a lo…

Source https://tinybuddha.com/blog/a-gentle-reminder-to-anyone-whos-struggling-this-holiday-season/

“It’s okay to want to be alone. It’s okay to take time for yourself.” ~Kate Allan

It’s the holiday season, the most wonderful time of the year, they say, but it’s not for all of us. For those of us coping with the loss of a loved one, family estrangement, loneliness, financial difficulties, or health struggles, the holidays can be one of the hardest times of the year.

For some of us the holidays can feel as if we have been cast out in the cold. As if we are forced to look through a window of a happy, loving family.

Many of us are filled with feelings of longing for things that can never be, such as more time with a lo…

Galectins in Neuroinflammation, a Potential Target

Source https://www.fightaging.org/archives/2022/12/galectins-in-neuroinflammation-a-potential-target/

In recent years, increasing attention has been given to the role of unresolved, chronic inflammation in the development of neurodegenerative disease. Normal tissue maintenance requires the involvement of immune cells, and inflammatory signaling is disruptive to that process. In the brain, immune cells take on a greater range of tasks than is the case elsewhere, becoming involved in maintenance of synaptic connections between neurons, for example. That too is disrupted by inflammatory signaling that changes the behavior of these cells.

Chronic inflammation in the absence of the usual causes, <a href="https://en.wikipedia.org/wiki/Pathoge…

Source https://www.fightaging.org/archives/2022/12/galectins-in-neuroinflammation-a-potential-target/

In recent years, increasing attention has been given to the role of unresolved, chronic inflammation in the development of neurodegenerative disease. Normal tissue maintenance requires the involvement of immune cells, and inflammatory signaling is disruptive to that process. In the brain, immune cells take on a greater range of tasks than is the case elsewhere, becoming involved in maintenance of synaptic connections between neurons, for example. That too is disrupted by inflammatory signaling that changes the behavior of these cells.

Chronic inflammation in the absence of the usual causes, <a href="https://en.wikipedia.org/wiki/Pathoge…

Working Effectively When You’re Overwhelmed

Source https://zenhabits.net/effective/

By Leo Babauta

I’ve noticed that so many people are feeling overwhelmed, scattered, and stressed – so much so that focus and effective work become incredibly difficult.

So what can we do to be more effective in the midst of this scattered, overwhelmed state?

Today I’m going to share the top three things I do to help myself find focus and effectiveness even when I’m at my most scattered.

The Interstitial Pause

The first thing I recommend is a pause between anything you do — I call it the Interstitial Pause.

Basically, instead of switching from one task to the next, I recommend a pause.

  • If you answer an email, take a pause — do you want to keep answering emails, or is there something more important you’d like to do?
  • If you finish working on a task, take a pause — would you like to take a break, or choose the next task from your list…

Source https://zenhabits.net/effective/

By Leo Babauta

I’ve noticed that so many people are feeling overwhelmed, scattered, and stressed – so much so that focus and effective work become incredibly difficult.

So what can we do to be more effective in the midst of this scattered, overwhelmed state?

Today I’m going to share the top three things I do to help myself find focus and effectiveness even when I’m at my most scattered.

The Interstitial Pause

The first thing I recommend is a pause between anything you do — I call it the Interstitial Pause.

Basically, instead of switching from one task to the next, I recommend a pause.

  • If you answer an email, take a pause — do you want to keep answering emails, or is there something more important you’d like to do?
  • If you finish working on a task, take a pause — would you like to take a break, or choose the next task from your list…

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