Source https://www.fightaging.org/archives/2025/05/investigating-a-methionine-restriction-mimetic-compound/
A sizable portion of the health benefits (and life extension in short-lived species) resulting from the practice of calorie restriction is triggered by sensing of levels of specific amino acids. Methionine is one of the more important such amino acids, and researchers have demonstrated that low-methionine diets can produce some fraction of the benefits of calorie restriction without reducing calorie intake, at least in rodents. Just as there are calorie restriction mimetics, molecules that trigger some of the same biochemical responses to calorie restriction, there should in princi…
Source https://www.fightaging.org/archives/2025/05/investigating-a-methionine-restriction-mimetic-compound/
A sizable portion of the health benefits (and life extension in short-lived species) resulting from the practice of calorie restriction is triggered by sensing of levels of specific amino acids. Methionine is one of the more important such amino acids, and researchers have demonstrated that low-methionine diets can produce some fraction of the benefits of calorie restriction without reducing calorie intake, at least in rodents. Just as there are calorie restriction mimetics, molecules that trigger some of the same biochemical responses to calorie restriction, there should in princi…
Source https://www.fightaging.org/archives/2025/05/impaired-ketogenesis-important-in-testicular-aging-in-mice-at-least/
The testes manufacture testosterone, generally important to long-term health. Further, germ cells resident in the testes manufacture sperm. This process of spermatogenesis is necessary for reproduction. Both of these functions decline with age. As is the case for near all outcomes of degenerative aging, the research community has yet to construct a clear model of cause and effect that reaches from the known root causes of aging to declining function in the tests. Cellular biochemistry is complex and incompletely mapped, and aging is a further complexity imposed upon those systems, not just as the level of individual cells, but also at the level of tissues containing enormous numbers of interacting ce…
Source https://www.fightaging.org/archives/2025/05/impaired-ketogenesis-important-in-testicular-aging-in-mice-at-least/
The testes manufacture testosterone, generally important to long-term health. Further, germ cells resident in the testes manufacture sperm. This process of spermatogenesis is necessary for reproduction. Both of these functions decline with age. As is the case for near all outcomes of degenerative aging, the research community has yet to construct a clear model of cause and effect that reaches from the known root causes of aging to declining function in the tests. Cellular biochemistry is complex and incompletely mapped, and aging is a further complexity imposed upon those systems, not just as the level of individual cells, but also at the level of tissues containing enormous numbers of interacting ce…
Source https://tinybuddha.com/blog/when-trying-to-be-good-with-food-makes-us-sick/
I was around five the first time I remember getting in trouble. It was nearing Christmas, and I wasn’t buying into the whole Santa story anymore. A magic man spends all year making toys, then drops down chimneys and delivers them all in one night? Nope. I may have only been five, but I was insulted that people expected me to buy that ridiculous story.
Feeling rather proud of myself for figuring it out, I demanded that my mom tell me the truth. And when she finally admitted Santa wasn’t real, I felt vindicated. But that wasn’t enough. I needed my younger cousins to know the truth, too, so I ran next door and told them.
I don’t remember what I said, but I remember what happened when my aunt found out. I can still picture it. I was s…
Source https://tinybuddha.com/blog/when-trying-to-be-good-with-food-makes-us-sick/
I was around five the first time I remember getting in trouble. It was nearing Christmas, and I wasn’t buying into the whole Santa story anymore. A magic man spends all year making toys, then drops down chimneys and delivers them all in one night? Nope. I may have only been five, but I was insulted that people expected me to buy that ridiculous story.
Feeling rather proud of myself for figuring it out, I demanded that my mom tell me the truth. And when she finally admitted Santa wasn’t real, I felt vindicated. But that wasn’t enough. I needed my younger cousins to know the truth, too, so I ran next door and told them.
I don’t remember what I said, but I remember what happened when my aunt found out. I can still picture it. I was s…
Source https://seniorplanet.org/articles-ask-joan-husband-wants-sexont/
Joan Price, Senior Planet’s Sex Columnist, counsels a woman whose husband’s desire for “instant sex” borders on assault.
The post Ask Joan: How To Deal With a Spouse Who Constantly Wants Sex appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-ask-joan-husband-wants-sexont/
Joan Price, Senior Planet’s Sex Columnist, counsels a woman whose husband’s desire for “instant sex” borders on assault.
The post Ask Joan: How To Deal With a Spouse Who Constantly Wants Sex appeared first on Senior Planet from AARP.
…
Source https://www.theminimalists.com/p491/
By The Minimalists
The Minimalists talk about the surprising beauty of uncertainty, and they wish a fond farewell to a beloved team member.
Listen to the Episode
Apple · Spotify · YouTube · <a href="https://www.patreon.com/c/theminimal…
Source https://www.theminimalists.com/p491/
By The Minimalists
The Minimalists talk about the surprising beauty of uncertainty, and they wish a fond farewell to a beloved team member.
Listen to the Episode
Apple · Spotify · YouTube · <a href="https://www.patreon.com/c/theminimal…
Source https://tinybuddha.com/blog/how-to-stop-living-to-please-and-stay-true-to-yourself/
“When you say yes to others, make sure you aren’t saying no to yourself.” ~Paulo Coelho
Have you ever felt like no matter how much you give, it’s never enough? Like your worth is measured by how useful, accommodating, or strong you can be for others?
This invisible burden is what I call the Good Girl / Good Boy Wound—a deep-seated conditioning that tells us our value lies in pleasing others, even at the cost of losing ourselves.
For generations, we’ve been taught to shape ourselves according to the expectations of those around us. Girls are often encouraged to be ‘nice’ and agreeable, while boys are praised for toughness and independence. These messages shape us into a…
Source https://tinybuddha.com/blog/how-to-stop-living-to-please-and-stay-true-to-yourself/
“When you say yes to others, make sure you aren’t saying no to yourself.” ~Paulo Coelho
Have you ever felt like no matter how much you give, it’s never enough? Like your worth is measured by how useful, accommodating, or strong you can be for others?
This invisible burden is what I call the Good Girl / Good Boy Wound—a deep-seated conditioning that tells us our value lies in pleasing others, even at the cost of losing ourselves.
For generations, we’ve been taught to shape ourselves according to the expectations of those around us. Girls are often encouraged to be ‘nice’ and agreeable, while boys are praised for toughness and independence. These messages shape us into a…
Source https://seniorplanet.org/articles-open-thread-stupid-life-lessons/
Stupid life lessons aren’t just for kids; what are some examples of dumb moves that taught us a lesson?
The post Open Thread: Stupid Life Lessons appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-open-thread-stupid-life-lessons/
Stupid life lessons aren’t just for kids; what are some examples of dumb moves that taught us a lesson?
The post Open Thread: Stupid Life Lessons appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/05/fight-aging-newsletter-may-19th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
Source https://www.fightaging.org/archives/2025/05/fight-aging-newsletter-may-19th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
Source https://seniorplanet.org/articles-techspert-digital-decluttering/
Over time, our devices can get cluttered just like our homes and garages do! The Techspert tackles this dilemma with an easy step-by-step guide to digital decluttering.
The post Ask The Techspert: Your Guide to Digital Decluttering appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-techspert-digital-decluttering/
Over time, our devices can get cluttered just like our homes and garages do! The Techspert tackles this dilemma with an easy step-by-step guide to digital decluttering.
The post Ask The Techspert: Your Guide to Digital Decluttering appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/05/does-air-pollution-contribute-meaningfully-to-iron-accumulation-in-the-aging-brain/
The consensus on air pollution is that it increases late life mortality, largely via an increase in chronic inflammation in exposed tissues in the lung. Researchers here propose that uptake of iron from inhaled particulate matter can contribute to the age-related increase of iron that takes place in the brain, and thus cause pathology. The researchers demonstrate that this introduction of iron from airborne pollutants into the brain can occur in mice, but the question (as usual) is whether in humans this has an effect size large enough to be important versus the inflammatory consequences of air pollution.
Both excess brain iron (Fe) and air pollution (AP) exposures are associated with increased risk for mul…
Source https://www.fightaging.org/archives/2025/05/does-air-pollution-contribute-meaningfully-to-iron-accumulation-in-the-aging-brain/
The consensus on air pollution is that it increases late life mortality, largely via an increase in chronic inflammation in exposed tissues in the lung. Researchers here propose that uptake of iron from inhaled particulate matter can contribute to the age-related increase of iron that takes place in the brain, and thus cause pathology. The researchers demonstrate that this introduction of iron from airborne pollutants into the brain can occur in mice, but the question (as usual) is whether in humans this has an effect size large enough to be important versus the inflammatory consequences of air pollution.
Both excess brain iron (Fe) and air pollution (AP) exposures are associated with increased risk for mul…
