Source https://www.fightaging.org/archives/2023/05/self-reported-data-from-several-hundred-rapamycin-self-experimenters/
Rapamycin is arguably the best of the many calorie restriction mimetic small molecules, treatments that can provoke some of the sweeping, favorable metabolic and cellular changes produced by a reduction in calorie intake. The data showing a modest slowing of aging in mice with rapamycin treatment is robust and well replicated, albeit only producing a 5-10% extension of life span, much less than has been shown to be possible via forms of calorie restriction. Like calorie restriction, rapamycin upregulates the cellular housekeeping process of <a href="https://en.wikipedia.org/w…
Source https://www.fightaging.org/archives/2023/05/self-reported-data-from-several-hundred-rapamycin-self-experimenters/
Rapamycin is arguably the best of the many calorie restriction mimetic small molecules, treatments that can provoke some of the sweeping, favorable metabolic and cellular changes produced by a reduction in calorie intake. The data showing a modest slowing of aging in mice with rapamycin treatment is robust and well replicated, albeit only producing a 5-10% extension of life span, much less than has been shown to be possible via forms of calorie restriction. Like calorie restriction, rapamycin upregulates the cellular housekeeping process of <a href="https://en.wikipedia.org/w…
Source https://seniorplanet.org/articles-profile-patrick-duffy-and-linda-purl/
In an exclusive interview, two Hollywood celebrities tell Senior Planet how the pandemic taught them never to give up on love.
The post Senior Planet talks to…Patrick Duffy and Linda Purl appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-profile-patrick-duffy-and-linda-purl/
In an exclusive interview, two Hollywood celebrities tell Senior Planet how the pandemic taught them never to give up on love.
The post Senior Planet talks to…Patrick Duffy and Linda Purl appeared first on Senior Planet from AARP.
…
Source https://tinybuddha.com/blog/could-exploration-be-the-purpose-of-life/
“Twenty years from now you will be more disappointed by the things you didn’t do than by the ones you did do. So, throw off the bowlines. Sail away from the safe harbour. Catch the trade winds in your sails. Explore. Dream. Discover.” ~Mark Twain
In 2022, I wanted to quit my job and didn’t know why. I was about to embark on a six-week trip to a country I’d always wanted to visit—New Zealand—to work in sports TV production. I loved the people I worked with, the company I worked for, and the buzz I got from live TV. Still, it wasn’t enough. I needed to explore these feelings further.
That word “exploration” was the key. It took me back to 2004, when I was in a hostel in Laguna Beach, …
Source https://tinybuddha.com/blog/could-exploration-be-the-purpose-of-life/
“Twenty years from now you will be more disappointed by the things you didn’t do than by the ones you did do. So, throw off the bowlines. Sail away from the safe harbour. Catch the trade winds in your sails. Explore. Dream. Discover.” ~Mark Twain
In 2022, I wanted to quit my job and didn’t know why. I was about to embark on a six-week trip to a country I’d always wanted to visit—New Zealand—to work in sports TV production. I loved the people I worked with, the company I worked for, and the buzz I got from live TV. Still, it wasn’t enough. I needed to explore these feelings further.
That word “exploration” was the key. It took me back to 2004, when I was in a hostel in Laguna Beach, …
Source https://www.fightaging.org/archives/2023/05/fight-aging-newsletter-may-29th-2023/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
Source https://www.fightaging.org/archives/2023/05/fight-aging-newsletter-may-29th-2023/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
Source https://www.fightaging.org/archives/2023/05/reviewing-mtor-inhibition-as-a-pharmacological-strategy-to-modestly-slow-aging/
It is arguably the case that we should look at small molecule mTOR inhibitors, such as rapamycin and its descendant rapalog compounds, as the most effective of the calorie restriction mimetic approaches developed to date. The practice of calorie restriction, eating as much as 40% fewer calories while still obtaining optimal levels of micronutrients, produces sweeping changes to metabolism. Some of these, such as increased autophagy and ot…
Source https://www.fightaging.org/archives/2023/05/reviewing-mtor-inhibition-as-a-pharmacological-strategy-to-modestly-slow-aging/
It is arguably the case that we should look at small molecule mTOR inhibitors, such as rapamycin and its descendant rapalog compounds, as the most effective of the calorie restriction mimetic approaches developed to date. The practice of calorie restriction, eating as much as 40% fewer calories while still obtaining optimal levels of micronutrients, produces sweeping changes to metabolism. Some of these, such as increased autophagy and ot…
Source https://www.fightaging.org/archives/2023/05/sufficient-physical-activity-correlates-with-a-halving-of-the-risk-of-influenza-mortality/
Analysis of a large epidemiological database here shows that sufficient exercise correlates with a halving of the risk of mortality due to influenza. Like many other studies, it also shows that too much exercise may be harmful, actually increasing the risk of mortality. While correlation does not imply causation, there is plenty of evidence for physical fitness and physical activity to reduce impacts of aging related to immune function. Alternative explanations revolve around the tendency of more robust individuals to conduct more exercise, while also tending to be more resilient independently of the effects of exercise.
A nationally representative sample of US adults (aged ≥18 years) who participated in the National Health Interview Survey from 1998 to 2018 were followed for mortality …
Source https://www.fightaging.org/archives/2023/05/sufficient-physical-activity-correlates-with-a-halving-of-the-risk-of-influenza-mortality/
Analysis of a large epidemiological database here shows that sufficient exercise correlates with a halving of the risk of mortality due to influenza. Like many other studies, it also shows that too much exercise may be harmful, actually increasing the risk of mortality. While correlation does not imply causation, there is plenty of evidence for physical fitness and physical activity to reduce impacts of aging related to immune function. Alternative explanations revolve around the tendency of more robust individuals to conduct more exercise, while also tending to be more resilient independently of the effects of exercise.
A nationally representative sample of US adults (aged ≥18 years) who participated in the National Health Interview Survey from 1998 to 2018 were followed for mortality …
Source https://www.fightaging.org/archives/2023/05/triglyceride-depletion-mimics-calorie-restriction-in-old-muscles/
Researchers here observe that triglyceride depletion in very aged muscles produces benefits, looking much like a form of calorie restriction that improves cell metabolism. This work was carried out in killifish, a highly regenerative species, so it remains to be seen as to whether a similar process operates in mammals, or whether it is in any way interesting or novel as a basis for therapy. Finding modest benefits in very late life is a poor alternative to focusing instead on methods of rejuvenation.
Sarcopenia, the age-r…
Source https://www.fightaging.org/archives/2023/05/triglyceride-depletion-mimics-calorie-restriction-in-old-muscles/
Researchers here observe that triglyceride depletion in very aged muscles produces benefits, looking much like a form of calorie restriction that improves cell metabolism. This work was carried out in killifish, a highly regenerative species, so it remains to be seen as to whether a similar process operates in mammals, or whether it is in any way interesting or novel as a basis for therapy. Finding modest benefits in very late life is a poor alternative to focusing instead on methods of rejuvenation.
Sarcopenia, the age-r…
Source https://www.fightaging.org/archives/2023/05/exercise-reduces-the-risk-of-parkinsons-disease/
Maintaining physical fitness remains one of the most proven approaches to modestly slow the progression of aging. The large study noted here provides an example of the long-term benefits of exercise. The scientists observe a reduction in Parkinson’s disease incidence in more active individuals. This is a pattern observed in near all age-related conditions, a good argument for putting in the time and effort needed to remain physically fit and active as one moves into later life.
The study included 95,354 female participants, mostly teachers, with an average age of 49 who did not have Parkinson’s disease at the start of the study. Researchers followed participants for three decades during which 1,074 participants developed Parkinson’s disease. Over the cou…
Source https://www.fightaging.org/archives/2023/05/exercise-reduces-the-risk-of-parkinsons-disease/
Maintaining physical fitness remains one of the most proven approaches to modestly slow the progression of aging. The large study noted here provides an example of the long-term benefits of exercise. The scientists observe a reduction in Parkinson’s disease incidence in more active individuals. This is a pattern observed in near all age-related conditions, a good argument for putting in the time and effort needed to remain physically fit and active as one moves into later life.
The study included 95,354 female participants, mostly teachers, with an average age of 49 who did not have Parkinson’s disease at the start of the study. Researchers followed participants for three decades during which 1,074 participants developed Parkinson’s disease. Over the cou…
Source https://www.fightaging.org/archives/2023/05/long-term-exercise-improves-neurogenesis-and-memory-function-in-mice/
Exercise is demonstrated to improve memory function, both immediately in the short-term, and over the long term of regular exercise and improved physical fitness. Exercise is also known to improve measures of neurogenesis, the creation of new neurons and integration into existing neural networks in the brain. This process is essential to learning and memory. Researchers here investigate the effects of exercise on neurogenesis in mice by labeling neurons in order to determine the contribution of adult neurogenesis to neural networks in the areas of th…
Source https://www.fightaging.org/archives/2023/05/long-term-exercise-improves-neurogenesis-and-memory-function-in-mice/
Exercise is demonstrated to improve memory function, both immediately in the short-term, and over the long term of regular exercise and improved physical fitness. Exercise is also known to improve measures of neurogenesis, the creation of new neurons and integration into existing neural networks in the brain. This process is essential to learning and memory. Researchers here investigate the effects of exercise on neurogenesis in mice by labeling neurons in order to determine the contribution of adult neurogenesis to neural networks in the areas of th…
Source https://www.fightaging.org/archives/2023/05/hunger-extends-life-in-flies-independently-of-calorie-intake/
Calorie restriction is the practice of eating fewer calories while still obtaining an optimal intake of micronutrients. In recent years work in flies has expanded the understanding of how perception of food and regulation of hunger interacts with the health benefits and slowed aging that result from calorie restriction. Allowing flies to scent food removes the benefits of a lowered calorie intake, for example.
Here, researchers generate a lineage of flies that can be induced to be constantly hungry, and they find that this produces similar benefits to calorie restriction even while the flies eat more than their unmodified peers. Relatedly, work on various different forms of calorie restriction in mammals suggests that <a href="https…
Source https://www.fightaging.org/archives/2023/05/hunger-extends-life-in-flies-independently-of-calorie-intake/
Calorie restriction is the practice of eating fewer calories while still obtaining an optimal intake of micronutrients. In recent years work in flies has expanded the understanding of how perception of food and regulation of hunger interacts with the health benefits and slowed aging that result from calorie restriction. Allowing flies to scent food removes the benefits of a lowered calorie intake, for example.
Here, researchers generate a lineage of flies that can be induced to be constantly hungry, and they find that this produces similar benefits to calorie restriction even while the flies eat more than their unmodified peers. Relatedly, work on various different forms of calorie restriction in mammals suggests that <a href="https…