First Results from the PEARL Trial of Rapamycin

Source https://www.fightaging.org/archives/2024/09/first-results-from-the-pearl-trial-of-rapamycin/

The largely crowdfunded Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL) clinical trial was organized by Lifespan.io, the funds raised in 2021. Those of us who advocate for more (and, importantly, more cost-effective) clinical trials of existing low-cost therapies that might at least modestly affect aging hoped for the PEARL trial to be a good example of the way in which one can put together and run a responsible, low-cost clinical trial. A blueprint that others could follow, or a first example of more trials that could be undertaken by organizations such as Lifespan.io. Everything moves …

Source https://www.fightaging.org/archives/2024/09/first-results-from-the-pearl-trial-of-rapamycin/

The largely crowdfunded Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL) clinical trial was organized by Lifespan.io, the funds raised in 2021. Those of us who advocate for more (and, importantly, more cost-effective) clinical trials of existing low-cost therapies that might at least modestly affect aging hoped for the PEARL trial to be a good example of the way in which one can put together and run a responsible, low-cost clinical trial. A blueprint that others could follow, or a first example of more trials that could be undertaken by organizations such as Lifespan.io. Everything moves …

Fight Aging! Newsletter, September 16th 2024

Source https://www.fightaging.org/archives/2024/09/fight-aging-newsletter-september-16th-2024/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/


Contents

Source https://www.fightaging.org/archives/2024/09/fight-aging-newsletter-september-16th-2024/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/


Contents

Open Thread: Old Friends

Source https://seniorplanet.org/articles-open-thread-old-friends/

Is there really anything as comforting and fun as getting together with old friends? How long have you had your oldest friend?

The post Open Thread: Old Friends appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-open-thread-old-friends/

Is there really anything as comforting and fun as getting together with old friends? How long have you had your oldest friend?

The post Open Thread: Old Friends appeared first on Senior Planet from AARP.

How I Created a Beautiful Life on the Other Side of Burnout

Source https://tinybuddha.com/blog/how-i-created-a-beautiful-life-on-the-other-side-of-burnout/

“If you dont give your mind and body a break, you’ll break. Stop pushing yourself through pain and exhaustion and take care of your needs. ~Lori Deschene

For forty-five minutes, I lay on my yoga mat in child’s pose, unable to move.

The exhaustion in my body felt like a thousand kilos, and the ache of failure pricked my eyes with tears.

Despite all my early morning runs, after-work bootcamps, and restricted meals, my body did not look like the bikini models I saw on Instagram.

Despite all my energy, efforts, and attention, my romantic relationship had fallen apart. No matter what I did or how …

Source https://tinybuddha.com/blog/how-i-created-a-beautiful-life-on-the-other-side-of-burnout/

“If you dont give your mind and body a break, you’ll break. Stop pushing yourself through pain and exhaustion and take care of your needs. ~Lori Deschene

For forty-five minutes, I lay on my yoga mat in child’s pose, unable to move.

The exhaustion in my body felt like a thousand kilos, and the ache of failure pricked my eyes with tears.

Despite all my early morning runs, after-work bootcamps, and restricted meals, my body did not look like the bikini models I saw on Instagram.

Despite all my energy, efforts, and attention, my romantic relationship had fallen apart. No matter what I did or how …

Distinct Changes in the Gut Microbiome of Parkinson's Patients

Source https://www.fightaging.org/archives/2024/09/distinct-changes-in-the-gut-microbiome-of-parkinsons-patients/

A number of neurodegenerative conditions have been linked to alterations in the gut microbiome, distinct from those already taking place with age. The balance of microbial populations making up the gut microbiome shifts with age to favor inflammation over production of beneficial metabolites. Researchers here make an effort to characterize gut microbiome changes associated specifically with Parkinson’s disease; whether these are indicative of greater inflammation or they touch on other mechanisms that can drive neurodegeneration …

Source https://www.fightaging.org/archives/2024/09/distinct-changes-in-the-gut-microbiome-of-parkinsons-patients/

A number of neurodegenerative conditions have been linked to alterations in the gut microbiome, distinct from those already taking place with age. The balance of microbial populations making up the gut microbiome shifts with age to favor inflammation over production of beneficial metabolites. Researchers here make an effort to characterize gut microbiome changes associated specifically with Parkinson’s disease; whether these are indicative of greater inflammation or they touch on other mechanisms that can drive neurodegeneration …

Meet the Trainer: Jess Fortin 

Source https://seniorplanet.org/articles-trainer-jess-fortin/

Meet Jess Fortin, kayaker, scrapbooker, and Senior Planet trainer in North Country New York. 

The post Meet the Trainer: Jess Fortin  appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-trainer-jess-fortin/

Meet Jess Fortin, kayaker, scrapbooker, and Senior Planet trainer in North Country New York. 

The post Meet the Trainer: Jess Fortin  appeared first on Senior Planet from AARP.

Digging in to the Relationship Between Aging, Periodontitis, and Cardiovascular Disease

Source https://www.fightaging.org/archives/2024/09/digging-in-to-the-relationship-between-aging-periodontitis-and-cardiovascular-disease/

In recent years, researchers have suggested that gum disease, periodontitis, may contribute to the development of cardiovascular disease and neurodegenerative conditions. Leakage of pathogens and harmful metabolites into the bloodstream at the gums, leading to an increased level of chronic inflammation, has been proposed as the important mechanism. This is a reasonable proposition. There is some debate over the degree of risk, however, and it is always poss…

Source https://www.fightaging.org/archives/2024/09/digging-in-to-the-relationship-between-aging-periodontitis-and-cardiovascular-disease/

In recent years, researchers have suggested that gum disease, periodontitis, may contribute to the development of cardiovascular disease and neurodegenerative conditions. Leakage of pathogens and harmful metabolites into the bloodstream at the gums, leading to an increased level of chronic inflammation, has been proposed as the important mechanism. This is a reasonable proposition. There is some debate over the degree of risk, however, and it is always poss…

I apologize for my sideburns and striped shirt

Source https://www.nerdfitness.com/blog/i-apologize-for-my-sideburns-and-striped-shirt/

For the first time in 10+ years, I rewatched my 2012 TEDx talk:

Nerd Fitness and Resetting the Game of Life.

My first thought: “Whoa, Steve. Those are some EPIC sideburns.”

My next thought: “Bold choice with the striped shirt, jeans, and flip flops!”

Then I gave myself some grace.

I’m deeply uncomfortable with the spotlight. I hate public speaking. It makes me want to vomit every single time. I also don’t like being on camera.

And yet, I have ideas that I think can help people.

Source https://www.nerdfitness.com/blog/i-apologize-for-my-sideburns-and-striped-shirt/

For the first time in 10+ years, I rewatched my 2012 TEDx talk:

Nerd Fitness and Resetting the Game of Life.

My first thought: “Whoa, Steve. Those are some EPIC sideburns.”

My next thought: “Bold choice with the striped shirt, jeans, and flip flops!”

Then I gave myself some grace.

I’m deeply uncomfortable with the spotlight. I hate public speaking. It makes me want to vomit every single time. I also don’t like being on camera.

And yet, I have ideas that I think can help people.

Considering Telomerase in Aging, Cancer, and Inflammation

Source https://www.fightaging.org/archives/2024/09/considering-telomerase-in-aging-cancer-and-inflammation/

Telomeres are repeated DNA sequences at the ends of chromosomes. A little of this length is lost with each cell division, one part of the countdown mechanism that limits the number of times a cell can replicate before becoming senescent or undergoing programmed cell death. In stem cells that must continue to produce daughter cells with long telomeres, the enzyme telomerase is active to lengthen telomeres. To the extent that stem cell activity declines with age, average telomere…

Source https://www.fightaging.org/archives/2024/09/considering-telomerase-in-aging-cancer-and-inflammation/

Telomeres are repeated DNA sequences at the ends of chromosomes. A little of this length is lost with each cell division, one part of the countdown mechanism that limits the number of times a cell can replicate before becoming senescent or undergoing programmed cell death. In stem cells that must continue to produce daughter cells with long telomeres, the enzyme telomerase is active to lengthen telomeres. To the extent that stem cell activity declines with age, average telomere…

Ask For Help

Source https://www.nerdfitness.com/blog/ask-for-help/

For a long time, I took a lot of pride in never needing to rely on other people.

I am a conflict-avoidant people-pleaser, so I would often pride myself on NEVER allowing myself to rely on others. I certainly wouldn’t let myself burden somebody else with my struggles.

I jokingly shared how I felt about asking for help the other day on Instagram:

<img loading="lazy" class="aligncenter" src="https://embed.filekitcdn.com/e/9KB1DyF5Ck6V78quVhayky/3mnD9hogd1GLNofpLyqxXW" alt="" width…

Source https://www.nerdfitness.com/blog/ask-for-help/

For a long time, I took a lot of pride in never needing to rely on other people.

I am a conflict-avoidant people-pleaser, so I would often pride myself on NEVER allowing myself to rely on others. I certainly wouldn’t let myself burden somebody else with my struggles.

I jokingly shared how I felt about asking for help the other day on Instagram:

<img loading="lazy" class="aligncenter" src="https://embed.filekitcdn.com/e/9KB1DyF5Ck6V78quVhayky/3mnD9hogd1GLNofpLyqxXW" alt="" width…

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