Source https://tinybuddha.com/blog/when-unhappiness-is-the-soul-crying-out-for-nourishment/
“Happiness is not something ready-made. It comes from your own actions.” ~Dalai Lama
I had been caught in a web of unhappiness for several months some time ago.
During those months, each morning looked the same. I would open my eyes, sigh in misery, and sit at the edge of the bed for a few minutes to mentally prepare myself for yet another day. It took all the energy within me, which was little, to stand up and go about the day.
Although I was unhappy for many months, I had come a long way in healing from severe anxiety. I experienced mild anxiety here and there, but severe anxiety was a distant memory and feeling.
About a few months into feeling unhappy, thoughts began to multiply and…
Source https://tinybuddha.com/blog/when-unhappiness-is-the-soul-crying-out-for-nourishment/
“Happiness is not something ready-made. It comes from your own actions.” ~Dalai Lama
I had been caught in a web of unhappiness for several months some time ago.
During those months, each morning looked the same. I would open my eyes, sigh in misery, and sit at the edge of the bed for a few minutes to mentally prepare myself for yet another day. It took all the energy within me, which was little, to stand up and go about the day.
Although I was unhappy for many months, I had come a long way in healing from severe anxiety. I experienced mild anxiety here and there, but severe anxiety was a distant memory and feeling.
About a few months into feeling unhappy, thoughts began to multiply and…
Source https://www.fightaging.org/archives/2025/01/a-snapshot-of-one-portion-of-the-ongoing-debate-over-causes-and-processes-of-aging/
A person dies, and there is the irresistible urge to draw a line under their life and summarize. So to the late Mikhail Blagosklonny and his contributions to the modern debate over the causes of aging. Hyperfunction theory doesn’t end with the originator, any more than any thread of scientific thought on the matter of aging – Robert Bradbury would no doubt be most interested to see where thought on the role of double stranded breaks in DNA as a mechanism of aging has ended up these days, were he still alive. Still, here we are, a chanc…
Source https://www.fightaging.org/archives/2025/01/a-snapshot-of-one-portion-of-the-ongoing-debate-over-causes-and-processes-of-aging/
A person dies, and there is the irresistible urge to draw a line under their life and summarize. So to the late Mikhail Blagosklonny and his contributions to the modern debate over the causes of aging. Hyperfunction theory doesn’t end with the originator, any more than any thread of scientific thought on the matter of aging – Robert Bradbury would no doubt be most interested to see where thought on the role of double stranded breaks in DNA as a mechanism of aging has ended up these days, were he still alive. Still, here we are, a chanc…
Source https://www.fightaging.org/archives/2025/01/mir-302b-rejuvenates-mice-by-allowing-senescent-cells-to-replicate-once-more/
Senescent cells accumulate with age, and contribute to the dysfunction of aging via their inflammatory secretions. A cell becomes senescent in response to reaching the Hayflick limit on replication, or in response to damage or stress. In the normal course of events, a senescent cell ceases replication, and this is an irreversible change. A few approaches have been demonstrated to reverse this aspect of the senescent state. The question is whether it is a good idea to do so. For example, senescent cells accumulate DNA damage on entry to the senescent state. Some senescent cells are senescent fo…
Source https://www.fightaging.org/archives/2025/01/mir-302b-rejuvenates-mice-by-allowing-senescent-cells-to-replicate-once-more/
Senescent cells accumulate with age, and contribute to the dysfunction of aging via their inflammatory secretions. A cell becomes senescent in response to reaching the Hayflick limit on replication, or in response to damage or stress. In the normal course of events, a senescent cell ceases replication, and this is an irreversible change. A few approaches have been demonstrated to reverse this aspect of the senescent state. The question is whether it is a good idea to do so. For example, senescent cells accumulate DNA damage on entry to the senescent state. Some senescent cells are senescent fo…
Source https://www.fightaging.org/archives/2025/01/immune-aging-as-a-driver-of-brain-aging/
The immune system isn’t just a means to defend against pathogens and potentially cancerous cells. It is also intimately involved in tissue function and maintenance, in regeneration from damage, in clearing debris, and communicates at a distance throughout the body via a panoply of signaling molecules. Beyond these functions, which are affected by the age-related decline of the immune system, there is also the point that chronic inflammation changes cell behavior for the worse. A sizable part of the problem of immune aging is the rise of unresolved inflammatory signaling and its effects on tissues.
For decades, t…
Source https://www.fightaging.org/archives/2025/01/immune-aging-as-a-driver-of-brain-aging/
The immune system isn’t just a means to defend against pathogens and potentially cancerous cells. It is also intimately involved in tissue function and maintenance, in regeneration from damage, in clearing debris, and communicates at a distance throughout the body via a panoply of signaling molecules. Beyond these functions, which are affected by the age-related decline of the immune system, there is also the point that chronic inflammation changes cell behavior for the worse. A sizable part of the problem of immune aging is the rise of unresolved inflammatory signaling and its effects on tissues.
For decades, t…
Source https://www.fightaging.org/archives/2025/01/mitochondrial-dysfunction-and-ovarian-aging/
The ovaries exhibit significant age-related loss of function somewhat ahead of the rest of the body. Why is this the case? There is no good answer at present as to why the underlying mechanisms of aging produce a faster decline in the ovaries. The ability to compare the biochemistry of aging in the ovaries with the biochemistry of aging in the rest of the body may be an opportunity to learn something about aging more generally, however. So one sees papers such as this one, in which researchers review what is known of the mitochondrial dysfunction associated with aging specifically in the ovaries versus its role in aging elsewhere in the body.
Ovarian aging is a major health concern for women. Ovarian aging is a…
Source https://www.fightaging.org/archives/2025/01/mitochondrial-dysfunction-and-ovarian-aging/
The ovaries exhibit significant age-related loss of function somewhat ahead of the rest of the body. Why is this the case? There is no good answer at present as to why the underlying mechanisms of aging produce a faster decline in the ovaries. The ability to compare the biochemistry of aging in the ovaries with the biochemistry of aging in the rest of the body may be an opportunity to learn something about aging more generally, however. So one sees papers such as this one, in which researchers review what is known of the mitochondrial dysfunction associated with aging specifically in the ovaries versus its role in aging elsewhere in the body.
Ovarian aging is a major health concern for women. Ovarian aging is a…
Source https://www.fightaging.org/archives/2025/01/hearing-impairment-correlates-with-risk-of-parkinsons-disease/
Hearing loss has been correlated with the risk of numerous forms of neurodegenerative condition. There are many studies similar to the one noted here, correlating degree of hearing loss with risk of Parkinson’s disease. While it seems to be the case that hearing loss can accelerate degeneration in the brain, a consequence of reduced input and brain activity in some areas, it is also the case that both hearing loss and neurodegenerative conditions arise from the same underlying forms of cell and tissue damage that drive aging more generally.
Hearing impairment is implicated as a risk factor for Parkinson’s disease (Parkinson’s) incidence, with evidence suggesting that clinically diagnosed hearing loss increases Parkinson’s risk 1.5-1.6 fold over 2-5 years follow up. How…
Source https://www.fightaging.org/archives/2025/01/hearing-impairment-correlates-with-risk-of-parkinsons-disease/
Hearing loss has been correlated with the risk of numerous forms of neurodegenerative condition. There are many studies similar to the one noted here, correlating degree of hearing loss with risk of Parkinson’s disease. While it seems to be the case that hearing loss can accelerate degeneration in the brain, a consequence of reduced input and brain activity in some areas, it is also the case that both hearing loss and neurodegenerative conditions arise from the same underlying forms of cell and tissue damage that drive aging more generally.
Hearing impairment is implicated as a risk factor for Parkinson’s disease (Parkinson’s) incidence, with evidence suggesting that clinically diagnosed hearing loss increases Parkinson’s risk 1.5-1.6 fold over 2-5 years follow up. How…
Source https://www.fightaging.org/archives/2025/01/intermittent-fasting-as-a-treatment-for-neurodegenerative-conditions/
Forms of calorie restriction and fasting tend to reduce the chronic inflammation characteristic of aging, and also produce numerous other beneficial alterations to the operation of metabolism. In the case of inflammatory age-related diseases, such as neurodegenerative conditions, a body of work exists to suggest that some benefit can be obtained via these lifestyle interventions. As pointed out here, the human data on the effects of calorie restriction and fasting on the progression of neurodegenerative conditions is far from rigorous and extensive enough to keep scientists happy, however.
Interest has grown in <a href="https://en.wik…
Source https://www.fightaging.org/archives/2025/01/intermittent-fasting-as-a-treatment-for-neurodegenerative-conditions/
Forms of calorie restriction and fasting tend to reduce the chronic inflammation characteristic of aging, and also produce numerous other beneficial alterations to the operation of metabolism. In the case of inflammatory age-related diseases, such as neurodegenerative conditions, a body of work exists to suggest that some benefit can be obtained via these lifestyle interventions. As pointed out here, the human data on the effects of calorie restriction and fasting on the progression of neurodegenerative conditions is far from rigorous and extensive enough to keep scientists happy, however.
Interest has grown in <a href="https://en.wik…
Source https://www.fightaging.org/archives/2025/01/the-hippo-signaling-pathway-is-connected-to-cellular-senescence/
Researchers have investigated inhibition of the Hippo pathway as a potential basis for regenerative therapies. Meanwhile some of the factors connected to Hippo, such as YAP and TAZ, have been connected to regulation of cellular senescence. This review outlines more of bigger picture of the relationship between Hippo signaling and cellular senescence, an important contribution to degenerative aging.
The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulat…
Source https://www.fightaging.org/archives/2025/01/the-hippo-signaling-pathway-is-connected-to-cellular-senescence/
Researchers have investigated inhibition of the Hippo pathway as a potential basis for regenerative therapies. Meanwhile some of the factors connected to Hippo, such as YAP and TAZ, have been connected to regulation of cellular senescence. This review outlines more of bigger picture of the relationship between Hippo signaling and cellular senescence, an important contribution to degenerative aging.
The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulat…
Source https://tinybuddha.com/blog/4-reasons-to-appreciate-hard-times-and-how-to-cultivate-gratitude/
“Thank you for all the challenges that built my character. Thank you for all the hard times that made me appreciate the good times.” ~Unknown
Gratitude is often associated with joy, blessings, and moments that bring us happiness. But what about the times when life feels hard? Can we still find gratitude in the pain and struggles that challenge us?
A good friend went through a difficult experience this year, and she taught me that the answer is yes. Her story left a profound impact on me.
Last month, my friend finished her final round of chemotherapy, and as we sat together, she surprised me by saying, “I’m grateful for this experience.” S…
Source https://tinybuddha.com/blog/4-reasons-to-appreciate-hard-times-and-how-to-cultivate-gratitude/
“Thank you for all the challenges that built my character. Thank you for all the hard times that made me appreciate the good times.” ~Unknown
Gratitude is often associated with joy, blessings, and moments that bring us happiness. But what about the times when life feels hard? Can we still find gratitude in the pain and struggles that challenge us?
A good friend went through a difficult experience this year, and she taught me that the answer is yes. Her story left a profound impact on me.
Last month, my friend finished her final round of chemotherapy, and as we sat together, she surprised me by saying, “I’m grateful for this experience.” S…