Ask The Techspert: TechBytes Episode 4

Source https://seniorplanet.org/articles-techspert-techbytes-4/

In this TechBytes episode the Techspert answers questions about finding your lost phone, Wi-Fi passwords, adding computer users, and more.

The post Ask The Techspert: TechBytes Episode 4 appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-techspert-techbytes-4/

In this TechBytes episode the Techspert answers questions about finding your lost phone, Wi-Fi passwords, adding computer users, and more.

The post Ask The Techspert: TechBytes Episode 4 appeared first on Senior Planet from AARP.

Regular Transfusion of Young Plasma Improves Health of Old Rats

Source https://www.fightaging.org/archives/2024/04/regular-transfusion-of-young-plasma-improves-health-of-old-rats/

Researchers here report on the results of transfusion of young rat plasma into old rats, starting every other week in later life. The study is small, and is one more data point to add to a mixed set of results. Plasma transfusion from young individual to old individual doesn’t look that impressive, all told, either in animals or in human patients. That doesn’t appear to be discouraging the community of researchers and developers who continue to work on approaches to transfusion that they believe may move the needle. The example here is a straightforward approach to transfusion, the procedure conducted every other week, and is one of the studies in which the intervention appears to work well enough to be interesting.

There is converging evidence that young blood conveys cells, <a…

Source https://www.fightaging.org/archives/2024/04/regular-transfusion-of-young-plasma-improves-health-of-old-rats/

Researchers here report on the results of transfusion of young rat plasma into old rats, starting every other week in later life. The study is small, and is one more data point to add to a mixed set of results. Plasma transfusion from young individual to old individual doesn’t look that impressive, all told, either in animals or in human patients. That doesn’t appear to be discouraging the community of researchers and developers who continue to work on approaches to transfusion that they believe may move the needle. The example here is a straightforward approach to transfusion, the procedure conducted every other week, and is one of the studies in which the intervention appears to work well enough to be interesting.

There is converging evidence that young blood conveys cells, <a…

Inconclusive Effects on Telomere Length from the CALERIE 2 Study

Source https://www.fightaging.org/archives/2024/04/inconclusive-effects-on-telomere-length-from-the-calerie-2-study/

In recent years, researchers have been putting more effect into analyses of the CALERIE 2 study of human calorie restriction. The study took place some years ago, but new results continue to be published. Here, researchers show that effects on telomere length and a related aging clock are inconclusive. Telomere length measured in the white blood cells of a blood sample is not a great measure of aging. It is highly variable between individuals, is influenced day to day changes in immune status, and it takes a fairly large study group for age-related trends to show up. It has rightfully been eclipsed by th…

Source https://www.fightaging.org/archives/2024/04/inconclusive-effects-on-telomere-length-from-the-calerie-2-study/

In recent years, researchers have been putting more effect into analyses of the CALERIE 2 study of human calorie restriction. The study took place some years ago, but new results continue to be published. Here, researchers show that effects on telomere length and a related aging clock are inconclusive. Telomere length measured in the white blood cells of a blood sample is not a great measure of aging. It is highly variable between individuals, is influenced day to day changes in immune status, and it takes a fairly large study group for age-related trends to show up. It has rightfully been eclipsed by th…

The Moment That Ruins Our Focus

Source https://zenhabits.net/moment-to-focus/

By Leo Babauta

I challenge you to do a test before you read the rest of this post (well OK, read the next two paragraphs then go do the challenge) …

Open an email that’s been sitting in your inbox but that you’ve been avoiding responding to or acting on. Pick the hardest one. Try to sit there, read the email, and then act on it and/or respond to it.

Then notice if there’s a moment when you want to just get away from that email. What does that moment feel like?

This moment of overwhelm and anxiety is usually invisible to most of us. It happens multiple times throughout the day (possibly dozens), and determines the actions we take or don’t take. But we rarely notice it — we just try to get away from it.

This is the moment that ruins our focus. It’s the moment that causes our procrastination and avoidance. It’s the moment that ruins our best habits and our b…

Source https://zenhabits.net/moment-to-focus/

By Leo Babauta

I challenge you to do a test before you read the rest of this post (well OK, read the next two paragraphs then go do the challenge) …

Open an email that’s been sitting in your inbox but that you’ve been avoiding responding to or acting on. Pick the hardest one. Try to sit there, read the email, and then act on it and/or respond to it.

Then notice if there’s a moment when you want to just get away from that email. What does that moment feel like?

This moment of overwhelm and anxiety is usually invisible to most of us. It happens multiple times throughout the day (possibly dozens), and determines the actions we take or don’t take. But we rarely notice it — we just try to get away from it.

This is the moment that ruins our focus. It’s the moment that causes our procrastination and avoidance. It’s the moment that ruins our best habits and our b…

MYC and USF1 are Downregulated in Aged Human Macrophages

Source https://www.fightaging.org/archives/2024/04/myc-and-usf1-are-downregulated-in-aged-human-macrophages/

Researchers here explore age-related changes that take place in the innate immune cells known as macrophages, as well as the precursor circulating cell type known as monocytes. Macrophages undertake a wide range of tasks, not just responsible for chasing down infectious pathogens, but also clearing molecular waste and cell debris, destroying problematic cells, and helping to coordinate regenerative processes following injury. Altered macrophage behavior is implicated in a range of age-related diseases, and this is also the case for changes that take place in the analogous cell population of microglia resident in the central nervous system. A better understanding of these alterations may lead to ways to res…

Source https://www.fightaging.org/archives/2024/04/myc-and-usf1-are-downregulated-in-aged-human-macrophages/

Researchers here explore age-related changes that take place in the innate immune cells known as macrophages, as well as the precursor circulating cell type known as monocytes. Macrophages undertake a wide range of tasks, not just responsible for chasing down infectious pathogens, but also clearing molecular waste and cell debris, destroying problematic cells, and helping to coordinate regenerative processes following injury. Altered macrophage behavior is implicated in a range of age-related diseases, and this is also the case for changes that take place in the analogous cell population of microglia resident in the central nervous system. A better understanding of these alterations may lead to ways to res…

Mitochondrial Transplantation Improves Muscle Function in Old Mice

Source https://www.fightaging.org/archives/2024/04/mitochondrial-transplantation-improves-muscle-function-in-old-mice/

The hundreds of mitochondria found in every cell are in effect power plants, their primary task being to manufacture the chemical energy store molecule adenosine triphosphate (ATP), which is used to power cellular processes. Mitochondria become damaged like every cellular component, and are recycled frequently. With age, however, changes in expression of mitochondrial and other proteins lead to dysfunctional recycling and dysfunctional mitochondria. ATP production suffers, side-effects of ATP production such as the generation of free radical molecules grow to become problematic, and cell function is impacted. This happens throughout the body, and is thought to…

Source https://www.fightaging.org/archives/2024/04/mitochondrial-transplantation-improves-muscle-function-in-old-mice/

The hundreds of mitochondria found in every cell are in effect power plants, their primary task being to manufacture the chemical energy store molecule adenosine triphosphate (ATP), which is used to power cellular processes. Mitochondria become damaged like every cellular component, and are recycled frequently. With age, however, changes in expression of mitochondrial and other proteins lead to dysfunctional recycling and dysfunctional mitochondria. ATP production suffers, side-effects of ATP production such as the generation of free radical molecules grow to become problematic, and cell function is impacted. This happens throughout the body, and is thought to…

Embracing Aging: I Want to Be Shiny from the Inside

Source https://tinybuddha.com/blog/embracing-aging-i-want-to-be-shiny-from-the-inside/

“Beautiful young people are accidents of nature, but beautiful old people are works of art.” ~Eleanor Roosevelt

Yesterday my son called me from college and asked about my day. I told him about my morning, which entailed celebrating my friend’s birthday with her daughter.

My friend passed away almost two years ago. Her daughter reached out to me a couple weeks ago and asked if I would share my morning with her to honor her mom. What a privilege and honor. Hands down YES to that.

The celebration was full of smiles, laughs, tea, stories, tears, yoga mats, birds, fresh air, and tight hugs. As I told my son the story, he asked if my friend’s daughter is cu…

Source https://tinybuddha.com/blog/embracing-aging-i-want-to-be-shiny-from-the-inside/

“Beautiful young people are accidents of nature, but beautiful old people are works of art.” ~Eleanor Roosevelt

Yesterday my son called me from college and asked about my day. I told him about my morning, which entailed celebrating my friend’s birthday with her daughter.

My friend passed away almost two years ago. Her daughter reached out to me a couple weeks ago and asked if I would share my morning with her to honor her mom. What a privilege and honor. Hands down YES to that.

The celebration was full of smiles, laughs, tea, stories, tears, yoga mats, birds, fresh air, and tight hugs. As I told my son the story, he asked if my friend’s daughter is cu…

Calorie Restriction and Fasting Benefit the Aging Heart

Source https://www.fightaging.org/archives/2024/04/calorie-restriction-and-fasting-benefit-the-aging-heart/

The practice of calorie restriction, intermittent fasting, and related strategies such the fasting mimicking diet are thought to produce benefits largely through increased or more efficient operation of the cellular maintenance process of autophagy. The various forms of autophagy work to remove damaged molecules and structures in the cell, and better cell function maintained over time throughout the body is expected to result in slowed aging. Certainly a great many of the approaches shown to slow aging in short-lived species are characterized by improved autophagy, and influence the same regulatory systems that are triggered by a low calorie intake a…

Source https://www.fightaging.org/archives/2024/04/calorie-restriction-and-fasting-benefit-the-aging-heart/

The practice of calorie restriction, intermittent fasting, and related strategies such the fasting mimicking diet are thought to produce benefits largely through increased or more efficient operation of the cellular maintenance process of autophagy. The various forms of autophagy work to remove damaged molecules and structures in the cell, and better cell function maintained over time throughout the body is expected to result in slowed aging. Certainly a great many of the approaches shown to slow aging in short-lived species are characterized by improved autophagy, and influence the same regulatory systems that are triggered by a low calorie intake a…

The Rodent Aging Interventions Database

Source https://www.fightaging.org/archives/2024/04/the-rodent-aging-interventions-database/

You might compare the LEV Foundation’s Rodent Aging Interventions Database with the DrugAge database, both emerging from the efforts of researchers who found themselves frequently reviewing the existing literature on age-slowing interventions in animal models. One of the things to bear in mind about the existing literature is that rodent studies that show an apparent modest slowing of aging frequently fail to replicate when later investors take a more rigorous approach, with larger numbers of mice. The history of the NIA Interventions Testing Program is largely a repeated demonstration of this point.

The Rodent Aging Interventions Database (RAID) project arose as a result of wor…

Source https://www.fightaging.org/archives/2024/04/the-rodent-aging-interventions-database/

You might compare the LEV Foundation’s Rodent Aging Interventions Database with the DrugAge database, both emerging from the efforts of researchers who found themselves frequently reviewing the existing literature on age-slowing interventions in animal models. One of the things to bear in mind about the existing literature is that rodent studies that show an apparent modest slowing of aging frequently fail to replicate when later investors take a more rigorous approach, with larger numbers of mice. The history of the NIA Interventions Testing Program is largely a repeated demonstration of this point.

The Rodent Aging Interventions Database (RAID) project arose as a result of wor…

5 Hidden Fears That May Be Secretly Sabotaging Your Life

Source https://tinybuddha.com/blog/5-hidden-fears-that-may-be-secretly-sabotaging-your-life/

“Sometimes what you’re most afraid of doing is the very thing that will set you free.” ~Robert Tew

I like to say I don’t regret much in life, because I know I’ve always done the best I could and have learned from every experience. But I’d be lying if I said I haven’t considered what my life might be like now if I’d overcome certain fears sooner.

For years I shut people out because I feared I might ruin relationships if I opened myself up to them. And there was a good reason for that—I’d damaged many relationships in the past by acting in response to my trauma.

I’d driven people away, sometimes with unnecessary drama that stemmed from insecurity and other times with dangerous beh…

Source https://tinybuddha.com/blog/5-hidden-fears-that-may-be-secretly-sabotaging-your-life/

“Sometimes what you’re most afraid of doing is the very thing that will set you free.” ~Robert Tew

I like to say I don’t regret much in life, because I know I’ve always done the best I could and have learned from every experience. But I’d be lying if I said I haven’t considered what my life might be like now if I’d overcome certain fears sooner.

For years I shut people out because I feared I might ruin relationships if I opened myself up to them. And there was a good reason for that—I’d damaged many relationships in the past by acting in response to my trauma.

I’d driven people away, sometimes with unnecessary drama that stemmed from insecurity and other times with dangerous beh…

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