The accumulation of senescent cells with advancing age is harmful. Selectively destroying those cells, even as few as a third of them, and even just once in later life, produces significant benefits to health and life span in mice. Cells become senescent in response to molecular damage, or to the signaling of nearby senescent cells, or on reaching the Hayflick limit on cell replication, or in response to tissue injury. In youth, senesc…
It is Plausible that Continual Removal of Senescence Cells Would Impair Regeneration and Limit Benefits to Life Span
The accumulation of senescent cells with advancing age is harmful. Selectively destroying those cells, even as few as a third of them, and even just once in later life, produces significant benefits to health and life span in mice. Cells become senescent in response to molecular damage, or to the signaling of nearby senescent cells, or on reaching the Hayflick limit on cell replication, or in response to tissue injury. In youth, senesc…