Source https://www.fightaging.org/archives/2022/02/disaggregases-as-the-basis-for-therapies-to-remove-amyloids/
A few proteins in the body are capable of misfolding or becoming otherwise altered in ways that encourage other molecules of the same protein to do the same. They can spread throughout a tissue and the body, given time, forming aggregates that precipitate into solid clumps and fibrils, surrounded by a halo of toxic biochemistry that harms cells. This is an age-related problem, likely because the systems of maintenance and recycling responsible for clearing aggregates falter with age, a victim of rising levels of molecular damage and the maladaptive reactions to that damage.
Amyloid-β, associated with Alzheimer’s disease, is likely the most well studied of the amyloids, with <…
Source https://www.fightaging.org/archives/2022/02/disaggregases-as-the-basis-for-therapies-to-remove-amyloids/
A few proteins in the body are capable of misfolding or becoming otherwise altered in ways that encourage other molecules of the same protein to do the same. They can spread throughout a tissue and the body, given time, forming aggregates that precipitate into solid clumps and fibrils, surrounded by a halo of toxic biochemistry that harms cells. This is an age-related problem, likely because the systems of maintenance and recycling responsible for clearing aggregates falter with age, a victim of rising levels of molecular damage and the maladaptive reactions to that damage.
Amyloid-β, associated with Alzheimer’s disease, is likely the most well studied of the amyloids, with <…
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