Source https://www.fightaging.org/archives/2022/07/whole-blood-exchange-and-the-peripheral-amyloid-sink-hypothesis/
Today I’ll point out an interesting study in mice that is based on the peripheral amyloid sink view of Alzheimer’s disease. Researchers repeatedly replaced the blood in Alzheimer’s model mice, that exhibit high levels of amyloid-β in the brain, with blood from normal mice. The result was less amyloid-β in the brain and better cognitive function. While one does always need to begin these discussions by noting that mouse models of Alzheimer’s disease are very artificial constructs, in that mice do not naturally develop the condition, and thus the models are all some form of genetic dysfunction that generates a particular pathology that may or may not map well to why Alzheimer’s is harmful in humans, this is nonetheless quite interesting.
T…
Source https://www.fightaging.org/archives/2022/07/whole-blood-exchange-and-the-peripheral-amyloid-sink-hypothesis/
Today I’ll point out an interesting study in mice that is based on the peripheral amyloid sink view of Alzheimer’s disease. Researchers repeatedly replaced the blood in Alzheimer’s model mice, that exhibit high levels of amyloid-β in the brain, with blood from normal mice. The result was less amyloid-β in the brain and better cognitive function. While one does always need to begin these discussions by noting that mouse models of Alzheimer’s disease are very artificial constructs, in that mice do not naturally develop the condition, and thus the models are all some form of genetic dysfunction that generates a particular pathology that may or may not map well to why Alzheimer’s is harmful in humans, this is nonetheless quite interesting.
T…
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