Source https://www.fightaging.org/archives/2022/11/checkpoint-inhibition-improves-clearance-of-senescent-cells/
Immune checkpoint inhibition, such as via targeting PD1, is used to fire up the immune system to attack cancer, temporarily disabling some of the natural mechanisms intended to prevent immune cells from running amok. In the case of cancer, this is intended to overcome the abuse of immune checkpoints by cancerous tissue, one of the many strategies by which an established tumor suppresses or co-opts the immune system. But does inhibition of immune checkpoints improve other aspects of immune function? Apparently so, as in today’s open access paper, researchers present evidence for a reduced burden of senescent cells following checkpoint inhibition.
Interestingly, it is unclear as to whether the improvement of meas…
Source https://www.fightaging.org/archives/2022/11/checkpoint-inhibition-improves-clearance-of-senescent-cells/
Immune checkpoint inhibition, such as via targeting PD1, is used to fire up the immune system to attack cancer, temporarily disabling some of the natural mechanisms intended to prevent immune cells from running amok. In the case of cancer, this is intended to overcome the abuse of immune checkpoints by cancerous tissue, one of the many strategies by which an established tumor suppresses or co-opts the immune system. But does inhibition of immune checkpoints improve other aspects of immune function? Apparently so, as in today’s open access paper, researchers present evidence for a reduced burden of senescent cells following checkpoint inhibition.
Interestingly, it is unclear as to whether the improvement of meas…
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